Sonic hedgehog and FGF8: Inadequate signals for the differentiation of a dopamine phenotype in mouse and human neurons in culture

Experimental Neurology

Volumn 169, Issue 1, 2001, Pages 36-43

  Stull, Natalie D ^a   Iacovitti, Lorraine ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Differentiation; Dopamine; Fibroblast growth factor; NT2 cells; Parkinson's disease; Sonic hedgehog; Stem cells; Striatum; Tissue culture; Tyrosine hydroxylase

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 8; MITOGEN ACTIVATED PROTEIN KINASE; SONIC HEDGEHOG PROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; MOUSE; NERVE CELL CULTURE; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; STRIATE CORTEX; TISSUE CULTURE;

EID: 0035025439     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7640     Document Type: Article

References (37)

1. Synergy between growth factors and neurotransmitters required for catecholamine differentiation in brain neurons
2. Protein kinase C activators work in synergy with specific growth factors to initiate tyrosine hydroxylase gene expression in striatal neurons in culture
3. Multiple signaling pathways direct the initiation of tyrosine hydroxylase gene expression in cultured brain neurons
4. Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator
5. Brain-derived neurotrophic factor works coordinately with partner molecules to initiate tyrosine hydroxylase expression in striatal neurons
6. Prospects for new restorative and neuroprotective treatments in Parkinson's disease
7. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
8. Mammalian neural stem cells
9. Molecular mechanisms underlying the synergistic induction of tyrosine hydroxylase gene expression by acidic fibroblast growth factor and co-activators
10. Functional synapses are formed between human Ntera2 (NT2, hNT) neurons grown on astrocytes
11. Protein kinase A is a common negative regulator of hedgehog signaling in the vertebrate embryo
12. Biochemical aspects of Parkinson's disease
13. Induction of midbrain dopamine neurons by sonic hedgehog
14. Effects of a novel differentiation factor on the development of catecholamine traits in noncatecholamine neurons from various regions of the rat brain: Studies in tissue culture
15. A muscle-derived factor induces expression of a catecholamine phenotype in cultured rat cerebral cortex
16. Induction of tyrosine hydroxylase in hNT neurons
17. Neruotransmitters, KCl, and antioxidants rescue striatal neurons from apoptotic cell death in culture
18. Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro
19. Cellular and molecular treatments of neurological diseases
20. Efficient generation of midbrain neurons from mouse embryonic stem cells
21. Update on fetal transplantation: The Swedish experience
22. An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry
23. The TIPS/TINS lecture - Catecholamines: From gene regulation to neuropsychiatric disorders
24. Co-expresssion of tyrosine hydroxylase and glutamic acid decarboxylase in dopamine differentiation factor-treated striatal neurons in culture
25. Long term integration and neuronal differentiation of human embryonal carcinoma cells (Ntera-2) transplanted into the caudoputamen of nude mice
26. cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog
27. Mutations affecting segment number and polarity in Drosophila
28. Neural transplantationas a therapy for Parkinson's disease
29. Neural stem cells - A versatile tool for cell replacement and gene therapy in the central nervous system
30. Plasticity and stem cells in the vertebrate nervous system
31. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain
32. Recovery of spatial learning by grafts of a conditionally immortalized hippocampal epithelial cell line into the ischaemia-lesioned hippocampus
33. Sonic hedgehog and FGF8: Inadequate signals for the differentiation of a dopamine phenotype in culture
34. Inhibition of protein kinase A phenocopies ectopic expressionof hedgehog in the CNS of wild-type and cyclops mutant embryos
35. Induction of a midbrain dopmaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
36. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
37. Retinoic acid induces cholinergic differentiation of Ntera 2 human embryonal carcinoma cells