Image generation of serotonin synthesis rates using α-methyltryptophan and PET

Journal of Computer Assisted Tomography

Volumn 22, Issue 5, 1998, Pages 777-785

  Okazawa, Hidehiko ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Brain, metabolism; Emission computed tomography; Serotonin; Stereotaxy; Tryptophan

Indexed keywords

AMINO ACIDS; COMPUTERIZED TOMOGRAPHY; LEAST SQUARES APPROXIMATIONS; POSITRON EMISSION TOMOGRAPHY;

ARTERIAL INPUT FUNCTION; BRAIN METABOLISM; EMISSION COMPUTED TOMOGRAPHY; FUNCTIONAL IMAGES; IMAGE GENERATIONS; INPUT FUNCTIONS; SEROTONIN; STEREOTAXY; SYNTHESIS RATE; TRYPTOPHAN;

PIXELS;

N METHYLTRYPTOPHAN; SEROTONIN;

ADULT; ARTICLE; BRAIN METABOLISM; CALCULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IMAGE DISPLAY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SYNTHESIS;

EID: 0031694254     PISSN: 03638715     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004728-199809000-00021     Document Type: Article

References (30)

1. Heninger GH. Indoleamine: the role of serotonin in clinical disorders. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology: the fourth generation of progress. New York: Raven Press, 1995:471-82.
2. Brewerton TD. Toward a unified theory of serotonin dysregulation in eating and related disorders. Psychoneuroendocrinology 1995; 20:561-90.
3. van Praag HM. Anxiety and aggression as pacemakers of depression: a dimensional variation of the serotonin hypothesis of depression. In: Mendlewicz J, Racagni G, Brunello N, eds. Current therapeutic approaches to panic and other anxiety disorders, Basel: Karger, 1994:144-50.
4. Young SN, Garelis E, Lal S, et al. Tryptophan and 5-hydroxy-indoleacetic acid in human cerebrospinal fluid. J Neurochem 1974; 22:777-9.
5. Diksic M, Nagahiro S, Sourkes TL, Yamamoto YL. A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab 1990;10: 1-12.
6. Nagahiro S, Takada A, Diksic M, Sourkes TL, Missala K, Yamamoto YL. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats. J Cereb Blood Flow Metab 1990;10:13-21.
7. Diksic M, Nagahiro S, Chaly T, Sourkes TL, Yamamoto YL, Feindel W. Serotonin synthesis rate measured in living dog brain by positron emission tomography. J Neurochem 1991;56:153-62.
8. Vanier M, Tsuiki K, Grdisa M, Worsley K, Diksic M. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis. J Neurochem 1995; 64:624-35.
9. Nishizawa S, Benkelfat C, Young SN, et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci. USA 1997;94:5308-13.
10. 11C]methyl-tryptophan. J Cereb Blood Flow Metab 1998;18 (in press).
11. Okazawa H, Yonekura Y, Fujibayashi Y, et al. Measurement of regional cerebral blood flow with copper-62-PTSM and a three-compartment model. J Nucl Med 1996;37:1089-93.
12. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
13. 11C]methyl-L-tryptophan for PET studies. Nucl Med Biol 1995;22:303-7.
14. Evans AC, Thompson CJ, Marrett S, Meyer E, Mazza M. Performance characteristics of the PC-2048: a new 15-slice encoded-crystal PET scanner for neurological studies. IEEE Trans Med Imag 1991;10:90-8.
15. Woods RP, Mazziotta JC, Cherry SR. MRI-PET registration with automated algorithm. J Comput Assist Tomogr 1993;17:536-46.
16. Evans AC, Marrett S, Torrescorzo J, Ku S, Collins L. MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas. J Cereb Blood Flow Metab 1991;11:A69-78.
17. Collins DL, Neelin P, Peter TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 1994;18:192-205.
18. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme, 1988.
19. Muzik O, Chugani DC, Chakraborty P, Mangner T, Chugani HT. Analysis of [C-11] alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab 1997;17:659-69.
20. Blomqvist G. On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 1984;4:629-32.
21. Takada A, Grdisa M, Diksic M, Gjedde A, Yamamoto YL. Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding. Neurochem Int 1993;23:351-9.
22. Salter M, Knowles RG, Pogson CI. How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain? J Biochem 1989;262:365-8.
23. Bloxam DL, Curzon G. A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation. J Neurochem 1978;31:1255-63.
24. Anderson GH. Control of protein and energy intake: role of plasma amino acids and brain neurotransmitters. Can J Physiol Pharmacol 1979;57:1043-57.
25. Shoaf SE, Schmall B. Pharmacokinetics of α-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis. J Pharmacol Exp Ther 1996;277:219-24.
26. Carson RE, Huang SC, Green MV. Weighted integration method for local cerebral blood flow measurements with positron emission tomography. J Cereb Blood Flow Metab 1986;6:245-58.
27. Ohta S, Meyer E, Thompson CJ, Gjedde A. Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. J Cereb Blood Flow Metab 1992;12: 179-92.
28. Friston KJ, Frith CD, Liddle PF, Frackowiak RSJ. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991;11:690-9.
29. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992;12:900-18.
30. Sourkes TL. Alpha-methyltryptophan and its action on tryptophan metabolism. Fed Proc 1971;30:897-903.