Therapeutic considerations of L-glutamine: A review of the literature

Alternative Medicine Review

Volumn 4, Issue 4, 1999, Pages 239-248

  Miller, Alan L ^a,b  

^a Thorne Research Incorporated   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE;

AMINO ACID METABOLISM; CITRIC ACID CYCLE; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG MECHANISM; HUMAN; IMMUNOMODULATION; INFECTION PREVENTION; INTESTINE MUCOSA PERMEABILITY; ORAL DRUG ADMINISTRATION; POSTOPERATIVE PERIOD; PROTEIN DEGRADATION; REVIEW; TOTAL PARENTERAL NUTRITION; WOUND HEALING;

DIGESTIVE PHYSIOLOGY; DIGESTIVE SYSTEM; GLUTAMINE; HUMANS; NEOPLASMS; PERMEABILITY; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0032857260     PISSN: 10895159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (64)

1. Askanazi J, Carpenter YA, Michelsen CE, et al. Muscle and plasma amino acids following injury: Influence of intercurrent infection. Ann Surg 1980;192:78-85.
2. Souba WW. Glutamine Physiology, Biochemistry, and Nutrition in Critical Illness. Austin, TX: R.G. Landes Co.; 1992.
3. Rohde T, MacLean DA, Klarlund Pedersen B. Glutamine, lymphocyte proliferation and cytokine production. Scand J Immunol 1996;44:648-650.
4. Ardawi MS. Glutamine and glucose metabolism in human peripheral lymphocytes. Metabolism 1988;37:99-103.
5. Li J, King BK, Janu PG, et al. Glycyl-L-glutamine-enriched total parenteral nutrition maintains small intestine gut-associated lymphoid tissue and upper respiratory tract immunity. JPEN J Parenter Enteral Nutr 1998;22:31-36.
6. O'Riordain MG, De Beaux A, Fearon KC. Effect of glutamine on immune function in the surgical patient. Nutrition 1996;12:S82-S84.
7. van der Hulst RR, von Meyenfeldt MF, Tiebosch A, et al. Glutamine and intestinal immune cells in humans. JPEN J Parenter Enteral Nutr 1997;21:310-315.
8. Gismondo MR, Drago L, Fassina MC, et al. Immunostimulating effect of oral glutamine. Dig Dis Sci 1998;43:1752-1754.
9. Parry-Billings M, Blomstrand E, McAndrew N, Newsholme EA. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 1990;11:S122-S123.
10. Walsh NP, Blannin AK, Robson PJ, Gleeson M. Glutamine, exercise and immune function. Links and possible mechanisms. Sports Med 1998;26:177-191.
11. Rowbottom DG, Keast D, Morton AR. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med 1996;21:80-97.
12. Newsholme EA. Biochemical mechanisms to explain immunosuppression in well-trained and overtrained athletes. Int J Sports Med 1994;15:S142-S147.
13. Wilmore DW. Metabolic support of the gastrointestinal tract. Potential gut protection during intensive cytotoxic therapy. Cancer 1997;79:1794-1803.
14. Souba WW, Strebel F, Bull J, et al. Interorgan glutamine metabolism in the tumor-bearing rat. J Surg Res 1988;44:720-726.
15. Souba WW. The gut as a nitrogen-processing organ in the metabolic response to critical illness. Nutr Support Services 1988;8:15-22.
16. Bakerville A, Hambleton P, Benbough JE. Pathological features of glutaminase toxicity. Br J Exp Pathol 1980;61:12-18.
17. O'Dwyer ST, Smith RJ, Hwang TL, Wilmore DW. Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. JPEN J Parent Enteral Nutr 1989;13:579-585.
18. Hwang TL, O'Dwyer ST, Smith RJ, et al. Preservation of small bowel mucosa using glutamine-enriched parenteral nutrition. Surg Forum 1987;38:56.
19. Grant J. Use of L-glutamine in total parenteral nutrition. J Surg 1988;44:506-513.
20. Barber AE, Jones WG, Minei JP, et al. Glutamine or fiber supplementation of a defined formula diet. Impact on bacterial translocation, tissue composition, and response to endotoxin. JPEN J Parent Enteral Nutr 1990;14:335-343.
21. Li J, Langkamp-Henken B, Suzuki K, Stahlgren LH. Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. JPEN J Parent Enteral Nutr 1994;18:303-307.
22. Khan J, Iiboshi Y, Cui L, et al. Alanyl-glutamine-supplemented parenteral nutrition increased luminal mucus gel and decreased permeability in the rat small intestine. JPEN J Parent Enteral Nutr 1999;23:24-31.
23. Wilmore DW, Smith RJ, O'Dwyer ST, et al. The gut: a central organ after surgical stress. Surgery 1988;104:917-923.
24. Souba WW, Klimberg VS, Hautamaki RD, et al. Oral glutamine reduces bacterial translocation following abdominal radiation. J Surg Res 1990;48:1-5.
25. Gianotti L, Alexander JW, Gennari R, et al. Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN J Parenter Enteral Nutr 1995;19:69-74.
26. Bai MX, Jiang ZM, Liu YW, et al. Effects of alanyl-glutamine on gut barrier function. Nutrition 1996;12:793-796.
27. Pangrahi P, Gewolb IH, Bamford P, Horvath K. Role of glutamine in bacterial transcytosis and epithelial cell injury. JPEN J Parenter Enteral Nutr 1997;21:75-80.
28. Chun H, Sasaki M, Fujiyama Y, Bamba T. Effect of glutamine on intestinal permeability and bacterial trarislocation after abdominal radiation injury in rats. J Gastroenterol 1997;32:189-195.
29. Foitzik T, Stufler M, Hotz HG, et al. Glutamine stabilizes intestinal permeability and reduces pancreatic infection in acute experimental pancreatitis. J Gastrointest Surg 1997;1:40-47.
30. Hammarqvist F, Luo J, Corgreave I, et al. Skeletal muscle glutathione is depleted in critically ill patients. Crit Care Med 1997;25:78-84.
31. Cao Y, Feng Z, Hoos A, Klimberg S. Glutamine enhances gut glutathione production. JPEN J Parenter Enteral Nutr 1998;22:224-227.
32. Ziegler TR, Smith RJ, O'Dwyer ST, et al. Increased intestinal permeability associated with infection in bum patients. Arch Surg 1988;123:1313-1319.
33. Roumen RM, van der Vliet JA, Wevers RA, Goris RJ. Intestinal permeability is increased after major vascular surgery. J Vasc Surg 1993;17:734-737.
34. Vinnars E, Bergstrom J, Furst P. Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann Surg 1975;182:665-671.
35. Roumen RM, Hendriks T, Wevers RA, Goris JA. Intestinal permeability after severe trauma and hemorrhagic shock is increased without relation to septic complications. Arch Surg 1993;128:453-457.
36. Houdijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998;352:772-776.
37. Biolo G, Toigo G, Ciocchi B, et al. Metabolic response to injury and sepsis: changes in protein metabolism. Nutrition 1997;13:S52-S57.
38. Wilmore DW. Catabolic illness: strategies for enhancing recovery. N Engl J Med 1991;325:695-702.
39. Askanazi J, Elwyn DH, Kinney JM, et al. Muscle and plasma amino acids after injury: The role of inactivity. Ann Surg 1978;188:797-803.
40. Wernerman J, Hammarkvist F, Rustom M, Vinnars E. Glutamine and ornithine-alpha-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma. Metabolism 1989;38:S63-S66.
41. Morlion BJ, Stehle P, Wachter P, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery. Ann Surg 1998;227:302-308.
42. Moore FA, Moore EE, Jones TN, et al. TEN versus TPN following major abdominal trauma-reduced septic morbidity. J Trauma 1989;29:916-923.
43. Kudsk KA, Croce MA, Fabian TC, et al. Enteral versus parenteral feeding. Ann Surg 192;215:503-511.
44. Klimberg VS, McClellan JL. Glutamine, cancer, and its therapy. Am J Surg 1996;172:418-424.
45. van der Hulst RR, von Meyenfeldt MF, Deutz NE, Soeters PB. Glutamine extraction by the gut is reduced in patients with depleted gastrointestinal cancer. Ann Surg 1997;225:112-121.
46. Kang YJ, Feng Y, Hatcher EL. Glutathione stimulates A549 cell proliferation in glutamine-deficient culture: the effect of glutamate supplementation. J Cell Physiol 1994;161:589-596.
47. Kang YJ. Buthionine sulfoximine spares intracellular glutamate: a possible mechanism for cell growth stimulation. Cell Mol Biol Res 1993;39:675-684.
48. Ollenschlager G, Simmel A, Roth E. Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures. Metabolism 1989;38:S40-S42.
49. Moyer MP, Armstrong A, Aust JB, et al. Effects of gastrin, glutamine, and somatostatin on the in vitro growth of normal and malignant human gastric mucosal cells. Arch Surg 1986;121:285-288.
50. Bartlett DL, Charland S, Torosian MH. Effect of glutamine on tumor and host growth. Ann Surg Oncol 1995;2:71-76.
51. Austgen TR, Dudrick PS, Sitren H, et al. The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues. Ann Surg 1992;215:107-113.
52. Klimberg VS, Souba WW, Salloum RM, et al. Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J Surg Res 1990;48:319-323.
53. Learn DB, Thomas EL. Inhibition of tumor cell glutamine uptake by isolated neutrophils. J Clin Invest 1988;82:789-796.
54. Fahr MJ, Kornbluth J, Blossom S, et al. Harry M. Vars Research Award. Glutamine enhances immunoregulation of tumor growth. JPEN J Parenter Enteral Nutr 1994;18:471-476.
55. Klimberg VS, Souba WW, Dolson DJ, et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 1990;66:62-68.
56. Yoshida S, Matsui M, Shirouzu Y, et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Ann Surg 1998;227:485-491.
57. Anderson PM, Ramsay NKC, Shu XO, et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998;22:339-344.
58. Griffiths RD. Outcome of critically ill patients after supplementation with glutamine. Nutrition 1997;13:752-754.
59. Klimberg VS, Nwokedi E, Hutchins L, et al. Glutamine facilitates chemotherapy while reducing toxicity. JPEN J Parenter Enteral Nutr 1992;16:83S-87S.
60. Fox AD, Kripke SA, De Paula J, et al. Effect of a glutamine-supplemented enterai diet on methotrexate-induced enterocolitis. JPEN J Parenter Enteral Nutr 1988;12:325-331.
61. Rouse K, Nwokedi E, Woodliff JE, et al. Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg 1995;221:420-426.
62. Klimberg VS, Pappas AA, Nwokedi E, et al. Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. Arch Surg 1992;127:1317-1320.
63. Rubio IT, Cao Y, Hutchins LF, et al. Effect of glutamine on methotrexate efficacy and toxicity. Ann Surg 1998;227:772-778; discussion 778-780.
64. Charland SL, Bartlett DL, Torosian MH. A significant methotrexate-glutamine pharmacokinetic interaction. Nutrition 1995;11:154-158.