Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 2 49-2, 2001, Pages

  Forlow, S Bradley ^a   Ley, Klaus ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b University of Virginia   (United States)

Author keywords

Intravital microscopy; Knockout mice; Neutrophil adhesion; Thioglycollate induced peritonitis; 4 integrins

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; PADGEM PROTEIN; SELECTIN; THIOGLYCOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; CREMASTER MUSCLE; KNOCKOUT MOUSE; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; LEUKOCYTE MIGRATION; MONONUCLEAR CELL; MOUSE; NEUTROPHIL; NONHUMAN; PERITONITIS; PRIORITY JOURNAL;

EID: 0035019149     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.2.h634     Document Type: Article

References (33)

1. Arbones ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon DJ, and Tedder TF. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1: 247-260, 1994.
2. Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, Doyle NA, Doerschuk CM, Ley K, and Beaudet AL. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183: 2329-2336, 1996.
3. Bullard DC, Qin L, Lorenzo I, Quinlin WM, Doyle NA, Bosse R, Vestweber D, Doerschuk CM, and Beaudet AL. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J Clin Invest 95: 1782-1788, 1995.
4. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036, 1991.
5. Diamond MS, Staunton DE, de Fougerolles AR, Stacker SA, Garcia-Aguilar J, Hibbs ML, and Springer TA. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol 111: 3129-3139, 1990.
6. Dustin ML and Springer TA. Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol 107: 321-331, 1988.
7. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, and Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 84: 563-574, 1996.
8. Jung U and Ley K. Regulation of E-selectin, P-selectin, and intercellular adhesion molecule 1 expression in mouse cremaster muscle vasculature. Microcirculation 4: 311-319, 1997.
9. Jung U and Ley K. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162: 6755-6762, 1999.
10. Jung U, Norman KE, Scharffetter-Kochanek K, Beaudet AL, and Ley K. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J Clin Invest 102: 1526-1533, 1998.
11. Jung U, Ramos CL, Bullard DC, and Ley K. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Am J Physiol Heart Circ Physiol 274: H1785-H1791, 1998.
12. Kansas GS. Selectins and their ligands: current concepts and controversies. Blood 88: 3259-3287, 1996.
13. Kanwar S, Bullard DC, Hickey MJ, Smith CW, Beaudet AL, Wolitzky BA, and Kubes P. The association between α4-integrin, P-selectin, and E-selectin in an allergic model of inflammation. J Exp Med 185: 1077-1087, 1997.
14. Krensky AM, Sanchez-Madrid F, Robbins E, Nagy JA, Springer TA, and Burakoff SJ. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J Immunol 131: 611-616, 1983.
15. Kubes P, Jutila M, and Payne D. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 95: 2510-2519, 1995.
16. Kunkel EJ, Jung U, Bullard DC, Norman KE, Wolitzky BA, Vestweber D, Beaudet AL, and Ley K. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med 183: 57-65, 1996.
17. Kunkel EJ and Ley K. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Circ Res 79: 1196-1204, 1996.
18. Labow MA, Norton CR, Rumberger JM, Lombard-Gillooly KM, Shuster DJ, Hubbard J, Bertko R, Knaack PA, Terry RW, and Harbison ML. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1: 709-720, 1994.
19. Ley K, Bullard DC, Arbones ML, Bosse R, Vestweber D, Tedder TF, and Beaudet AL. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J Exp Med 181: 669-675, 1995.
20. Lipowsky HH and Zweifach BW. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15: 93-101, 1978.
21. Marlin SD and Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51: 813-819, 1987.
22. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, and Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74: 541-554, 1993.
23. Miyake K, Weissman IL, Greenberger JS, and Kincade PW. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med 173: 599-607, 1991.
24. Mizgerd JP, Quinlan WM, LeBlanc BW, Kutkoski GJ, Billiard DC, Beaudet AL, and Doerschuk CM. Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice. J Leukoc Biol 64: 291-297, 1998.
25. Pries AR. A versatile video image analysis system for microcirculatory research. Int J Microcirc Clin Exp 7: 327-345, 1988.
26. Reneman RS, Woldhuis B, oude Egbrink MGA, Slaaf DW, and Tangelder GJ. Advances in Cardiovascular Engineering. New York: Plenum, 1992, p. 25-40.
27. Robinson SD, Prenette PS, Rayburn H, Cummiskey M, Ullman-Cullere M, Wagner DD, and Hynes RO. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci USA 96: 11452-11457, 1999.
28. Sligh JEJ, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, and Beaudet AL. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci USA 90: 8529-8533, 1993.
29. Smith CW, Marlin SD, Rothlein R, Toman C, and Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83: 2008-2017, 1989.
30. Springer T, Galfre G, Secher DS, and Milstein C. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 9: 301-306, 1979.
31. Steeber DA, Campbell MA, Basit A, Ley K, and Tedder TF. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci USA 95: 7562-7567, 1998.
32. Steeber DA, Tang ML, Green NE, Zhang XQ, Sloane JE, and Tedder TF. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163: 2176-2186, 1999.
33. Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, and Gutierrez-Ramos J.C. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med 180: 95-109, 1994.