Effects of in vivo heregulin β1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy

American Journal of Pathology

Volumn 158, Issue 5, 2001, Pages 1871-1880

  O'Shea, Sue ^a   Johnson, Kent ^b   Clark, Ross ^c   Sliwkowski, Mark X ^c   Erickson, Sharon L ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; NEU DIFFERENTIATION FACTOR; RECOMBINANT HEREGULIN BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST HYPERPLASIA; CONTROLLED STUDY; EPITHELIUM HYPERPLASIA; FEMALE; GENE TARGETING; HEART NERVE; HETEROZYGOSITY; HISTOPATHOLOGY; INTESTINE EPITHELIUM; MALE; MORTALITY; MOUSE; NONHUMAN; PANCREAS; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; STOMACH PARIETAL CELL;

EID: 0035016942     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64144-2     Document Type: Article

References (50)

1. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
2. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
3. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation
4. ErbB receptors and EGF-like ligands: Cell lineage determination and oncogenesis through combinatorial signaling
5. Identification of heregulin, a specific activator of p185ErbB2
6. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
7. Ligand-specific activation of HER4/ p180ErbB4, a fourth member of the epidermal growth factor receptor family
8. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene
9. Heregulin induces tyrosine phosphorylation of HER4/ p180ErbB4
10. Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180ErbB4 receptor
11. Isolation and characterization of ErbB3, a third member of the ErbB/epidermal growth factor family: Evidence of overexpression in a subset of human mammary tumors
12. Insect cell-expressed p180 ErbB3 possesses an impaired tyrosine kinase activity
13. Diversification of neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
14. Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C or GTPase-activation protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members
15. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
16. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the ErbB3 gene product
17. Heregulin-β is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells
18. The ErbB3 gene product is a receptor for heregulin
19. A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling
20. ErbB3 and erbB4 function as the respective Iow and high affinity receptors of all neu differentiation factor/heregulin isoforms
21. Multiple essential functions of neuregulin in development
22. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
23. ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2 and heregulin deficient mice
24. Requirement for neuregulin receptor ErbB2 in neural and cardiac development
25. Neuregulins in development
26. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks
27. Differential expression of ARiA isoforms in the rat brain
28. Analysis of heregulin-induced ErbB2 phosphorylation with a high-throughput kinase receptor activation enzyme-linked immunosorbent assay
29. Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland
30. Expression of heregulin α, erbB2 and erbB3 and their influences on proliferation of gastric epithelial cells
31. Overexpression of transforming growth factor-α alters differentiation of gastric cell lineages
32. Neuregulins promote survival and growth of cardiac myocytes
33. Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development
34. Neu differentiation factor is a neuron-glial signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors
35. Cell death in the Schwann cell lineage and its regulation by neuregulin
36. A dual role of erbB2 in myelination and in expansion of the Schwann cell precursor pool
37. Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity
38. NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice
39. Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli
40. Pharmacokinetics in pregnancy and placental drug transfer
41. Actions of placental and fetal adrenal steroid hormones in primate pregnancy
42. Decrease of c-ErbB2 and c-myc RNA levels in tamoxifen-treated breast cancer
43. Elevated serum c-ErbB-2 antigen levels and decreased response to hormone therapy of breast cancer
44. An intron 1 enhancer element mediates oestrogen-induced suppression of ErbB2 expression
45. AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen
46. Stage- and tissue-specific expression of the neu oncogene in rat development
47. Expression of the c-erbB3 protein in normal human adult and fetal tissues
48. Neural expression and chromosomal mapping of neu differentiation factor to 8p12-p21
49. Transforming growth factor α disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice
50. Glial growth factor restricts mammalian neural crest stem cells to a glial fate