메뉴 건너뛰기




Volumn 183, Issue 3, 2000, Pages 301-313

Heregulin-β is especially potent in activating phosphatidylinositol 3- kinase in nontransformed human mammary epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN; NEU DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; WORTMANNIN;

EID: 0034091963     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(200006)183:3<301::AID-JCP2>3.0.CO;2-W     Document Type: Article
Times cited : (20)

References (68)
  • 1
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • Aaronson SA. 1991. Growth factors and cancer. Science 254:1146-1153.
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaronson, S.A.1
  • 3
    • 0024601010 scopus 로고
    • PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
    • Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC. 1989. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167-175.
    • (1989) Cell , vol.57 , pp. 167-175
    • Auger, K.R.1    Serunian, L.A.2    Soltoff, S.P.3    Libby, P.4    Cantley, L.C.5
  • 5
    • 0342285716 scopus 로고
    • Tumor progression in breast cancer
    • Rhim JS, Dritschilo J, editors. Totowa, NJ: The Humana Press
    • Band V, Sager R. 1991. Tumor progression in breast cancer. In: Rhim JS, Dritschilo J, editors. Neoplastic transformation in human cell culture. Totowa, NJ: The Humana Press. p 169-178.
    • (1991) Neoplastic Transformation in Human Cell Culture , pp. 169-178
    • Band, V.1    Sager, R.2
  • 8
    • 0028176477 scopus 로고
    • A neu acquaintance of erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
    • Carraway KL, Cantley LC. 1994. A neu acquaintance of erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78:5-8.
    • (1994) Cell , vol.78 , pp. 5-8
    • Carraway, K.L.1    Cantley, L.C.2
  • 10
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 s6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. 1994. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911.
    • (1994) Mol Cell Biol , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 12
    • 0023665027 scopus 로고
    • c-src: A possible phosphatidylinositol kinase
    • c-src: a possible phosphatidylinositol kinase. Cell 50:1031-1037.
    • (1987) Cell , vol.50 , pp. 1031-1037
    • Courtneidge, S.A.1    Heber, A.2
  • 14
    • 0025328284 scopus 로고
    • The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity
    • Di Fiore PP, Segatto O, Lonardo F, Faziolo F, Pierce JH, Aaronson SA. 1990. The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity. Mol Cell Biol 10:2749-2756.
    • (1990) Mol Cell Biol , vol.10 , pp. 2749-2756
    • Di Fiore, P.P.1    Segatto, O.2    Lonardo, F.3    Faziolo, F.4    Pierce, J.H.5    Aaronson, S.A.6
  • 15
    • 0026085468 scopus 로고
    • A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
    • Escobedo JA, Kaplan DR, Kavanaugh M, Turck CW, Williams LT. 1991a. A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol 11:1125-1132.
    • (1991) Mol Cell Biol , vol.11 , pp. 1125-1132
    • Escobedo, J.A.1    Kaplan, D.R.2    Kavanaugh, M.3    Turck, C.W.4    Williams, L.T.5
  • 16
    • 0025727594 scopus 로고
    • CDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of pi3-kinase to the PDGF β-receptor
    • Escobedo JA, Navankasattusas S, Kavanaugh WM, Milfay D, Fried VA, Williams LT. 1991b. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor. Cell 65:75-82.
    • (1991) Cell , vol.65 , pp. 75-82
    • Escobedo, J.A.1    Navankasattusas, S.2    Kavanaugh, W.M.3    Milfay, D.4    Fried, V.A.5    Williams, L.T.6
  • 17
    • 0025678124 scopus 로고
    • The influence of growth factors on the proliferative potential of normal and primary breast cancer-derived human breast epithelial cells
    • Ethier SP, Summerfelt RM, Cundiff KC, Asch BB. 1990. The influence of growth factors on the proliferative potential of normal and primary breast cancer-derived human breast epithelial cells. Breast Cancer Res Treat 17:221-230.
    • (1990) Breast Cancer Res Treat , vol.17 , pp. 221-230
    • Ethier, S.P.1    Summerfelt, R.M.2    Cundiff, K.C.3    Asch, B.B.4
  • 18
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines in a growth factor receptor bind to specific molecules that mediate different signaling pathways
    • Fantl WJ, Escobedo JA, Martin GA, Turck CW, del-Rosario M, McCormick F, Willams LT. 1992. Distinct phosphotyrosines in a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413-423.
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.W.4    Del-Rosario, M.5    McCormick, F.6    Willams, L.T.7
  • 19
    • 0028120910 scopus 로고
    • Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase Cγ or GTPase-activating protein, distinguishes erbB-3 signaling from that of other erbB/EGFR family members
    • Fedi P, Pierce JH, Di Fiore PP, Kraus MH. 1994. Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase Cγ or GTPase-activating protein, distinguishes erbB-3 signaling from that of other erbB/EGFR family members. Mol Cell Biol 14:492-500.
    • (1994) Mol Cell Biol , vol.14 , pp. 492-500
    • Fedi, P.1    Pierce, J.H.2    Di Fiore, P.P.3    Kraus, M.H.4
  • 20
    • 0025690737 scopus 로고
    • Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: A mechanism for receptor transregulation
    • Goldman R, Ben Levy R, Peles E, Yarden Y. 1990. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry 29:11024-11028.
    • (1990) Biochemistry , vol.29 , pp. 11024-11028
    • Goldman, R.1    Ben Levy, R.2    Peles, E.3    Yarden, Y.4
  • 21
    • 0345178412 scopus 로고
    • Serum-free growth of human mammary epithelial cells: Rapid clonal growth in defined medium and extended serial passage with pituitary extract
    • Hammond SL, Ham RG, Stampfer MR. 1984. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc Natl Acad Sci USA 81:5435-5439.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5435-5439
    • Hammond, S.L.1    Ham, R.G.2    Stampfer, M.R.3
  • 24
    • 0026537450 scopus 로고
    • Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
    • Hu P, Margolis B, Skolnik Y, Lammers R, Ullrick A, Schlessinger J. 1992. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol Cell Biol 12:981-990.
    • (1992) Mol Cell Biol , vol.12 , pp. 981-990
    • Hu, P.1    Margolis, B.2    Skolnik, Y.3    Lammers, R.4    Ullrick, A.5    Schlessinger, J.6
  • 25
    • 0028000009 scopus 로고
    • Activation of the ras signalling pathway in human breast cancer cells overexpressing erbB-2
    • Janes PW, Daly RJ, deFazio A, Sutherland RL. 1994. Activation of the ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene 9:3601-3608.
    • (1994) Oncogene , vol.9 , pp. 3601-3608
    • Janes, P.W.1    Daly, R.J.2    DeFazio, A.3    Sutherland, R.L.4
  • 26
    • 0023665111 scopus 로고
    • Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
    • Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley LC, Roberts TM. 1987. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021-1029.
    • (1987) Cell , vol.50 , pp. 1021-1029
    • Kaplan, D.R.1    Whitman, M.2    Schaffhausen, B.3    Pallas, D.C.4    White, M.5    Cantley, L.C.6    Roberts, T.M.7
  • 29
    • 0028077047 scopus 로고
    • Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbb3 gene product
    • Kim H-H, Sierke SL, Koland JG. 1994. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product. J Biol Chem 269:24747-24755.
    • (1994) J Biol Chem , vol.269 , pp. 24747-24755
    • Kim, H.-H.1    Sierke, S.L.2    Koland, J.G.3
  • 30
    • 0024023873 scopus 로고
    • EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbb-2 protein in the mammary tumor cell line SK-BR-3
    • King CR, Borrello I, Bellot F, Comoglio P, Schlessinger J. 1988. EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J 7:1647-1651.
    • (1988) EMBO J , vol.7 , pp. 1647-1651
    • King, C.R.1    Borrello, I.2    Bellot, F.3    Comoglio, P.4    Schlessinger, J.5
  • 32
    • 0024326947 scopus 로고
    • Isolation and characterization of ERBB3, a third member of the ERBB/ epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors
    • Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA. 1989. Isolation and characterization of ERBB3, a third member of the ERBB/ epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci USA 86:9193-9197.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9193-9197
    • Kraus, M.H.1    Issing, W.2    Miki, T.3    Popescu, N.C.4    Aaronson, S.A.5
  • 33
    • 0028018858 scopus 로고
    • The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1: Stimulation by insulin and inhibition by wortmannin
    • Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelley KL. 1994. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1: stimulation by insulin and inhibition by wortmannin. J Biol Chem 269:20648-20652.
    • (1994) J Biol Chem , vol.269 , pp. 20648-20652
    • Lam, K.1    Carpenter, C.L.2    Ruderman, N.B.3    Friel, J.C.4    Kelley, K.L.5
  • 34
    • 0025687686 scopus 로고
    • The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand
    • Lonardo F, Di Marco E, King CR, Pierce JH, Segatto O, Aaronson SA, Di Fiore PP. 1990. The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biologist 2:992-1003.
    • (1990) New Biologist , vol.2 , pp. 992-1003
    • Lonardo, F.1    Di Marco, E.2    King, C.R.3    Pierce, J.H.4    Segatto, O.5    Aaronson, S.A.6    Di Fiore, P.P.7
  • 35
    • 0028796895 scopus 로고
    • NDF/heregulin activates MAP kinase and p70/p85 s6 knase during proliferation or differentiation of mammary epithelial cells
    • Marte BM, Graus-Porta D, Jeschke M, Fabbro D, Hynes NE, Taverna D. 1995. NDF/heregulin activates MAP kinase and p70/p85 S6 knase during proliferation or differentiation of mammary epithelial cells. Oncogene 10:167-175.
    • (1995) Oncogene , vol.10 , pp. 167-175
    • Marte, B.M.1    Graus-Porta, D.2    Jeschke, M.3    Fabbro, D.4    Hynes, N.E.5    Taverna, D.6
  • 37
    • 0028940789 scopus 로고
    • P53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin
    • Merlo GR, Basolo F, Fiore L, Duboc L, Hynes NE. 1995. p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin. J Cell Biol 128:1185-1196.
    • (1995) J Cell Biol , vol.128 , pp. 1185-1196
    • Merlo, G.R.1    Basolo, F.2    Fiore, L.3    Duboc, L.4    Hynes, N.E.5
  • 38
    • 0027535742 scopus 로고
    • Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate
    • Nakanishi H, Brewer KA, Exton JH. 1993. Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate. J Biol Chem 268:13-16.
    • (1993) J Biol Chem , vol.268 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 40
    • 0025816451 scopus 로고
    • Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase Cγ
    • Peles E, Ben-Levy R, Or E, Ullrich A, Yarden Y. 1991. Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase Cγ. EMBO J 10:2077-2087.
    • (1991) EMBO J , vol.10 , pp. 2077-2087
    • Peles, E.1    Ben-Levy, R.2    Or, E.3    Ullrich, A.4    Yarden, Y.5
  • 41
    • 0026780327 scopus 로고
    • Regulated coupling of the neu receptor to phosphatidylinositol 3′-kinase and its release by oncogenic activation
    • Peles E, Lamprecht R, Ben-Levy R, Tzahar E, Yarden Y. 1992. Regulated coupling of the neu receptor to phosphatidylinositol 3′-kinase and its release by oncogenic activation. J Biol Chem 267: 12266-12274.
    • (1992) J Biol Chem , vol.267 , pp. 12266-12274
    • Peles, E.1    Lamprecht, R.2    Ben-Levy, R.3    Tzahar, E.4    Yarden, Y.5
  • 45
    • 0029824114 scopus 로고    scopus 로고
    • erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent mammary carcinoma cells with c-erbB-2 gene amplification
    • erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent mammary carcinoma cells with c-erbB-2 gene amplification. Cell Growth Differ 7:551-561.
    • (1996) Cell Growth Differ , vol.7 , pp. 551-561
    • Ram, T.G.1    Ethier, S.P.2
  • 46
    • 0029029137 scopus 로고
    • Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin-like growth factor-i in human mammary epithelial cells
    • Ram TG, Kokeny KE, Dilts CA, Ethier SP. 1995. Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin-like growth factor-I in human mammary epithelial cells. J Cell Physiol 163:589-596.
    • (1995) J Cell Physiol , vol.163 , pp. 589-596
    • Ram, T.G.1    Kokeny, K.E.2    Dilts, C.A.3    Ethier, S.P.4
  • 48
    • 0028584245 scopus 로고
    • The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors
    • Roche S, Koegl M, Courtneige SA. 1994. The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci USA 91:9185-9189.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneige, S.A.3
  • 49
    • 0030830039 scopus 로고    scopus 로고
    • Gamma-heregulin: A novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175
    • Schaefer G, Fitzpatrick VD, Sliwkowski MX. 1998. Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175. Oncogene 15:1385-1394.
    • (1998) Oncogene , vol.15 , pp. 1385-1394
    • Schaefer, G.1    Fitzpatrick, V.D.2    Sliwkowski, M.X.3
  • 50
    • 0025189622 scopus 로고
    • Deletion of the kinase insert sequence of platelet-derived growth factor β-receptor affects receptor kinase activity and signal transduction
    • Severinsson L, Ek B, Mellstrom K, Claesson-Welsh L, Heldin C-H. 1990. Deletion of the kinase insert sequence of platelet-derived growth factor β-receptor affects receptor kinase activity and signal transduction. Mol Cell Biol 10:801-809.
    • (1990) Mol Cell Biol , vol.10 , pp. 801-809
    • Severinsson, L.1    Ek, B.2    Mellstrom, K.3    Claesson-Welsh, L.4    Heldin, C.-H.5
  • 51
    • 0025289853 scopus 로고
    • Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase
    • Shurtleff SA, Downing JR, Rock CO, Hawkins SA, Roussel MF, Sherr CJ. 1990. Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase. EMBO J 9:2415-2421.
    • (1990) EMBO J , vol.9 , pp. 2415-2421
    • Shurtleff, S.A.1    Downing, J.R.2    Rock, C.O.3    Hawkins, S.A.4    Roussel, M.F.5    Sherr, C.J.6
  • 52
    • 0033561296 scopus 로고    scopus 로고
    • Elevated expression of activated forms of neu/erbB-2 and erbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer
    • Siegel PM, Ryan ED, Cardiff RD, Muller WJ. 1999. Elevated expression of activated forms of neu/erbB-2 and erbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J 18:2149-2164.
    • (1999) EMBO J , vol.18 , pp. 2149-2164
    • Siegel, P.M.1    Ryan, E.D.2    Cardiff, R.D.3    Muller, W.J.4
  • 53
    • 0025921611 scopus 로고
    • Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
    • Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83-90.
    • (1991) Cell , vol.65 , pp. 83-90
    • Skolnik, E.Y.1    Margolis, B.2    Mohammadi, M.3    Lowenstein, E.4    Fischer, R.5    Drepps, A.6    Ullrich, A.7    Schlessinger, J.8
  • 55
    • 0028302018 scopus 로고
    • ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
    • Soltoff SP, Carraway III KL, Prigent SA, Gullick WG, Cantley LC. 1994. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol 14:3550-3558.
    • (1994) Mol Cell Biol , vol.14 , pp. 3550-3558
    • Soltoff, S.P.1    Carraway K.L. III2    Prigent, S.A.3    Gullick, W.G.4    Cantley, L.C.5
  • 57
    • 0019172106 scopus 로고
    • Growth of normal human mammary epithelial cells in culture
    • Stampfer MR, Hallowes RC, Hackett AJ. 1980. Growth of normal human mammary epithelial cells in culture. In Vitro 16:415-425.
    • (1980) Vitro , vol.16 , pp. 415-425
    • Stampfer, M.R.1    Hallowes, R.C.2    Hackett, A.J.3
  • 58
    • 0029079038 scopus 로고
    • Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with src and p85α
    • Stover DR, Becker M, Liebetanz J, Lydon NB. 1995. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with src and p85α. J Biol Chem, 270: 15591-15597.
    • (1995) J Biol Chem , vol.270 , pp. 15591-15597
    • Stover, D.R.1    Becker, M.2    Liebetanz, J.3    Lydon, N.B.4
  • 59
    • 0026482524 scopus 로고
    • Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol
    • Susa M, Keeler M, Varticovski L. 1992. Platelet-derived growth factor activates membrane-associated phosphatidylinositol 3-kinase and mediates its translocation from the cytosol. J Biol Chem 2687: 22951-22956.
    • (1992) J Biol Chem , vol.2687 , pp. 22951-22956
    • Susa, M.1    Keeler, M.2    Varticovski, L.3
  • 61
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ, Yarden Y. 1996. A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 16:5276-5287.
    • (1996) Mol Cell Biol , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 62
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 64
    • 0025194462 scopus 로고
    • neu protein and EGF receptor modulates EGF receptor function
    • neu protein and EGF receptor modulates EGF receptor function. Cell 61:1339-1347.
    • (1990) Cell , vol.61 , pp. 1339-1347
    • Wada, T.1    Qian, X.2    Greene, M.I.3
  • 65
    • 0029162564 scopus 로고
    • Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3
    • Wallasch C, Weiβ FU, Niederfellner G, Jalla B, Issing W, Ullrich A. 1995. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J 14:4267-4275.
    • (1995) EMBO J , vol.14 , pp. 4267-4275
    • Wallasch, C.1    Weib, F.U.2    Niederfellner, G.3    Jalla, B.4    Issing, W.5    Ullrich, A.6
  • 67
    • 0021828496 scopus 로고
    • Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
    • Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM. 1985. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 315: 239-242.
    • (1985) Nature , vol.315 , pp. 239-242
    • Whitman, M.1    Kaplan, D.R.2    Schaffhausen, B.3    Cantley, L.4    Roberts, T.M.5
  • 68
    • 0026566156 scopus 로고
    • Insulin like growth factor-I induces limited association of phosphatidylinositol 3-kinase to its receptor
    • Yamamoto K, Lapetina EG, Moxham CP. 1992. Insulin like growth factor-I induces limited association of phosphatidylinositol 3-kinase to its receptor. Endocrinology 130:1490-1498.
    • (1992) Endocrinology , vol.130 , pp. 1490-1498
    • Yamamoto, K.1    Lapetina, E.G.2    Moxham, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.