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16 McCarthy TL, Ji C, Chen Y, et al.: Time-and dose-related interactions between glucocorticoid and cyclic adenosine 3′,5′-monophosphate on CCAAT/enhancer-binding protein-dependent insulin-like growth factor I expression by osteoblasts. Endocrinology 2000, 141:127-137.
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18 Manolagas SC: Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 2000, 21:115-137. This review of evidence supports the importance of altered bone cell numbers in various bone diseases rather than changes in the function of differentiated bone cells.
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23 Hofbauer LC, Gori F, Riggs BL, et al.: Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1999, 140:4382-4389. This study demonstrates changes in osteoprotegerin and RANKL expression with glucocorticoids that potentially accounts for an early phase of osteoclastic bone resorption with glucocorticoid treatment.
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30 Cooper MS, Walker EA, Biand R, et al.: Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone. Bone 2000, 27:375-381. This is the first study reporting that osteoblasts in vivo express glucocorticoid-modifying enzymes and can interconvert inactive and active corticosteroids.
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32 Adachi JD, Bensen WG, Brown J, et al.: Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med 1997, 337:382-387. This is a randomized controlled trial of the bisphosphonate etidronate in glucocorticoid-induced osteoporosis.
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Glucocorticoid-Induced Osteoporosis Intervention Study Group This is a randomized controlled trial of the bisphosphonate alendronate in glucocorticoid-induced osteoporosis
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33 Saag KG, Emkey R, Schnitzer TJ, et al.: Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med 1998, 339:292-299. This is a randomized controlled trial of the bisphosphonate alendronate in glucocorticoid-induced osteoporosis.
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34 Cohen S, Levy RM, Keller M, et al.: Risedronate therapy prevents corticosteroid-induced bone loss: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis Rheum 1999, 42:2309-2318. This is the first randomized controlled trial of the bisphosphonate risedronate in glucocorticoid-induced osteoporosis.
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39 Chavassieux PM, Arlot ME, Roux JP, et al.: Effects of alendronate on bone quality and remodeling in glucocorticoid-induced osteoporosis: a histomorphometric analysis of transiliac biopsies. J Bone Miner Res 2000, 15:754-762.
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40 Reginster JY, Kuntz D, Verdickt W, et al.: Prophylactic use of alfacalcidol in corticosteroid-induced osteoporosis. Osteoporos Int 1999, 9:75-81.
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41 Lane NE, Sanchez S, Modin GW, et al.: Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis. Results of a randomized controlled clinical trial. J Clin Invest 1998, 102:1627-1633. This randomized controlled trial of PTH injections in patients with established glucocorticoid-induced osteoporosis demonstrated a substantial anabolic action of PTH at the spine and subsequently the hip.
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