The pathophysiology of tremor

Muscle and Nerve

Volumn 24, Issue 6, 2001, Pages 716-735

  Deuschl, Günther ^a   Raethjen, Jan ^a   Lindemann, Michael ^a   Krack, Paul ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Basal ganglia; Cerebellum; Essential tremor; Orthostatic tremor; Oscillations; Parkinson's disease; Physiology; Tremor

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALCOHOL; ANTIDEPRESSANT AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; LITHIUM;

ALCOHOL WITHDRAWAL; BASAL GANGLION; BRAIN STEM; CEREBELLUM DISEASE; DISEASE CLASSIFICATION; DRUG INDUCED DISEASE; DRUG INTOXICATION; DYSTONIA; ESSENTIAL TREMOR; HUMAN; NEUROPATHY; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; TREMOR;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; HUMANS; REFERENCE VALUES; TREMOR;

EID: 0035008836     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mus.1063     Document Type: Review

References (242)

1. Aisen ML, Adelstein BD, Romero J, Morris A, Rosen M. Peripheral mechanical loading and the mechanism of the tremor of chronic alcoholism. Arch Neurol 1992;49: 740-742.
2. Alajouanine T, Thurel R, Hornet T. Un cas de myoclonies vélo-pharyngées et oculaires: hypertrophic de l'olive bulbaire avec état fenêtré. Rev Neurol 1935;61:853-872.
3. Alajouanine T, Thurel R, Ullmann M. Un cas de myoclonieépilepsie: association d'épilepsie généralisée et d'un syndrome myoclonique facio-linguo-vélo-palatin. Rev Neurol 1938;69:59-61.
4. Alexander GE, Crutcher MD, DeLong MR. Basal gangliathalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 1990;85:119-146.
5. Allum JH, Dietz V, Freund HJ. Neuronal mechanisms underlying physiological tremor. J Neurophysiol 1978;41: 557-571.
6. Altenburger H. Zur Pathophysiologie psychogener Bewegungsstörungen. Zsch Neurol Psychiatry 1937;158:133-135.
7. Ambold A. Eine Kriegsneurose in ärztlicher Selbstbeobachtung. Münch Med Wochenschr 1922;9:311.
8. Aminoff MJ, Dedo HH, Izdebski K. Clinical aspects of spasmodic dysphonia. J Neurol Neurosurg Psychiatry 1978;41: 361-365.
9. Amjad AM, Halliday DM, Rosenberg JR, Conway BA. An extended difference of coherence test for comparing and combining several independent coherence estimates: theory and application to the study of motor units and physiological tremor. J Neurosci Methods 1997;73:69-79.
10. Anonymous. Bekenntnisse eines Zitterkünstlers. Hannoverscher Anzeiger 1920;24 August:12.
11. Anonymous. Writing tremor and writing dystonia. Mov Disord 1990;5:354-355.
12. Antonini A, Moeller JR, Nakamura T, Spetsieris P, Dhawan V, Eidelberg D. The metabolic anatomy of tremor in Parkinson's disease. Neurology 1998;51:803-810.
13. Bain P, Brin M, Deuschl G, Elble R, Jankovic J, Findley L, Koller B, Pahwa R. Criteria for the diagnosis of essential tremor. Neurology 2000;54(Suppl. 4):57.
14. Bain PG, Britton TC, Jenkins IH, Thompson PD, Rothwell JC, Thomas PK, Brooks DJ, Marsden CD. Tremor associated with benign IgM paraproteinaemic neuropathy. Brain 1996; 119:789-799.
15. Baker SN, Kilner JM, Pinches EM, Lemon RN. The role of synchrony and oscillations in the motor output. Exp Brain Res 1999;128:109-117.
16. Baker SN, Olivier E, Lemon RN. Coherent oscillations in monkey motor cortex and hand muscle EMG show task-dependent modulation. J Physiol (Lond) 1997;501:225-241.
17. Bastian AJ, Thach WT. Cerebellar outflow lesions: a comparison of movement deficits resulting from lesions at the levels of the cerebellum and thalamus. Ann Neurol 1995;38: 881-892.
18. Berardelli A, Hallett M, Rothwell JC, Agostino R, Manfredi M, Thompson PD, Marsden CD. Single-joint rapid arm novements in normal subjects and in patients with motor disorders. Brain 1996;119:661-674.
19. Bergman H, Feingold A, Nini A, Raz A, Slovin H, Abeles M, Vaadia E. Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends Neurosci 1998;21:32-38.
20. Bergman H, Raz A, Feingold A, Nini A, Nelken I, Hansel D, Ben-Pazi H, Reches A. Physiology of MPTP tremor. Mov Disord 1998;13:29-34.
21. Boecker H, Brooks DJ. Functional imaging of tremor. Mov Disord 1998;13:64-72.
22. Boecker H, Wills AJ, Ceballos BA, Samuel M, Thompson PD, Findley LJ, Brooks DJ. The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol 1996;39:650-658.
23. Boroojerdi B, Ferbert A, Foltys H, Kosinski CM, Noth J, Schwarz M. Evidence for a non-orthostatic origin of orthostatic tremor. J Neurol Neurosurg Psychiatry 1999;66: 284-288.
24. Britton TC, Thompson PD. Primary orthostatic tremor. BMJ 1995;310:143-144.
25. Britton TC, Thompson PD, Day BL, Rothwell JC, Findley LJ, Marsden CD. Rapid wrist movements in patients with essential tremor. The critical role of the second agonist burst. Brain 1994;117:39-47.
26. Britton TC, Thompson PD, van der Kamp W. Rothwell JC, Day BL, Findley LJ, Marsden CD. Primary orthostatic tremor: further observations in six cases. J Neurol 1992;239: 209-217.
27. Brodal A. Neurological anatomy in relation to clinical medicine. New York: Oxford University Press; 1981.
28. Brooks DJ. PET and SPECT studies in Parkinson's disease. Baillieres Clin Neurol 1997;6:69-87.
29. Brooks DJ. PET studies on the early and differential diagnosis of Parkinson's disease. Neurology 1993;43(suppl):S6-S16.
30. Brooks DJ, Playford ED, Ibanez V, Sawle GV, Thompson PD, Findley LJ, Marsden CD. Isolated tremor and disruption of the nigrostriatal dopaminergic system: an 18F-dopa PET study. Neurology 1992;42:1554-1560.
31. Brown P, Farmer SF, Halliday DM, Marsden J, Rosenberg JR. Coherent cortical and muscle discharge in cortical myoclonus. Brain 1999;122:461-472.
32. Brown P, Salenius S, Rothwell JC, Hari R. Cortical correlate of the Piper rhythm in humans. J Neurophysiol 1998;80: 2911-2917.
33. Buzsaki G, Smith A, Berger S, Fisher LJ, Gage FH. Petit mal epilepsy and parkinsonian tremor: hypothesis of a common pacemaker. Neuroscience 1990;36:1-14.
34. Caligiuri MP, Lacro JP, Jeste DV. Incidence and predictors of drug-induced parkinsonism in older psychiatric patients treated with very low doses of neuroleptics. J Clin Psychopharmacol 1999;19:322-328.
35. Chacko RC, Marsh BJ, Marmion J, Dworkin RJ, Telschow R. Lithium side effects in elderly bipolar outpatients. Hillside J Clin Psychiatry 1987;9:79-88.
36. Chang YY, Tsai TC, Shih PY, Liu JS. Unilateral symptomatic palatal myoclonus: MRI evidence of contralateral inferior olivary lesion. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1993; 9:371-376.
37. Claus D, Schocklmann HO, Dietrich HJ. Long latency muscle responses in cerebellar diseases. Eur Arch Psychiatry Neurol Sci 1986;235:355-360.
38. Colebatch JG, Findley LJ, Frackowiak RS, Marsden CD, Brooks DJ. Preliminary report: activation of the cerebellum in essential tremor. Lancet 1990;336:1028-1030.
39. Conrad B, Brooks VB. Cerebellare Bewegungsstörung im Tierversuch. J Neurol 1975;209:165-179.
40. Conway BA, Halliday DM, Farmer SF, Shahani U, Maas P, Weir AI, Rosenberg JR. Synchronization between motor cortex and spinal motoneuronal pool during the performance of a maintained motor task in man. J Physiol (Lond) 1995; 489:917-924.
41. Couch JR. Dystonia and tremor in spasmodic torticollis. Adv Neurol 1976;14:245-258.
42. Dalakas MC, Teravainen H, Engel WK. Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies. Incidence and management. Arch Neurol 1984; 41:711-714.
43. Deiber MP, Pollak P, Passingham R, Landais P, Gervason C, Cinotti L, Friston K, Frackowiak R, Mauguiere F, Benabid AL. Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography. Brain 1993;116:267-279.
44. Deuschl G, Bain P, Brin M. Scientific committee. Consensus statement of the Movement Disorder Society on Tremor. Mov Disord 1998;13:2-23.
45. Deuschl G, Heinen F, Guschlbauer B, Schneider S, Glocker FX, Lucking CH. Hand tremor in patients with spasmodic torticollis. Mov Disord 1997;12:547-552.
46. Deuschl G, Heinen F, Kleedorfer B, Wagner M, Lücking CH, Poewe W. Clinical and polymyographic investigation of spasmodic torticollis. J Neurol 1992;239:9-15.
47. Deuschl G, Jost S, Schumacher M. Symptomatic palatal tremor is associated with signs of cerebellar dysfunction. J Neurol 1996;243:553-556.
48. Deuschl G, Koster B, Lucking CH, Scheidt C. Diagnostic and pathophysiological aspects of psychogenic tremors. Mov Disord 1998;13:294-302.
49. Deuschl G, Krack P, Lauk M, Timmer J. Clinical neurophysiology of tremor. J Clin Neurophysiol 1996;13:110-121.
50. Deuschl G, Lücking CH, Quintern J. Orthostatischer Tremor: Klinik, Pathophysiologie und Therapie. Z EEG-EMG 1987; 18:13-19.
51. Deuschl G, Mischke G, Schenck E, Schulte-Mönting J, Lücking CH. Symptomatic and essential rhythmic palatal myoclonus. Brain 1990;113:1645-1672.
52. Deuschl G, Raethjen J, Baron R, Lindemann M, Wilms H, Krack P. The pathophysiology of Parkinsonian tremor: a review. J Neurol 2000;247(Suppl. 5):V33-V48.
53. Deuschl G, Toro C, Valls SJ, Hallett M. Symptomatic and essential palatal tremor. 3. Abnormal motor learning. J Neurol Neurosurg Psychiatry 1996;60:520-525.
54. Deuschl G, Toro C, Valls-Sole J, Zeffiro T, Zee DS, Hallett M. Symptomatic and essential palatal tremor. I. Clinical, physiological and MRI analysis. Brain 1994;117:775-788.
55. Deuschl G, Wenzelburger R, Löffler K, Raethjen J, Stolze H, Essential tremor and cerebellar dysfunction: clinical and kinematic analysis of intention tremor. Brain 2000;123:1568-1580.
56. Deuschl G, Wilms H, Krack P, Wurker M, Heiss WD. Function of the cerebellum in Parkinsonian rest tremor and Holmes' tremor. Ann Neurol 1999;46:126-128.
57. Diener HC, Dichgans J. Pathophysiology of cerebellar ataxia. Mov Disord 1992;7:95-109.
58. Dietz V. Tremor. Mechanical effect of the discharge bebavior of motor neurons. Fortschr Med 1978;96:215-219.
59. Duane DD. Familial cervical dystonia, head tremor, and scoliosis: a case report. Adv Neurol 1998;78:117-120.
60. Dubinsky RM, Gray CS, Koller WC. Essential tremor and dystonia. Neurology 1993;43:2382-2384.
61. Duchen LW, Eicher EM, Jacobs JM, Scaravilli F, Teixeira F. Hereditary leucodystrophy in the mouse: the new mutant twitcher. Brain 1980;103:695-710.
62. Duncan R, Bone I, Melville ID. Essential tremor cured by infarction adjacent to the thalamus. J Neurol Neurosurg Psychiatry 1988;51:591-592.
63. Dupuis MJ, Delwaide PJ, Boucquey D, Gonsette RE. Homolateral disappearance of essential tremor after cerebellar stroke. Mov Disord 1989;4:183-187.
64. Eidelberg D, Moeller JR, Ishikawa T, Dhawan V, Spetsieris P, Chaly T, Robeson W, Dahl JR, Margouleff D. Assessment of disease severity in parkinsonism with fluorine-18-fluorodeoxyglucose and PET. J Nucl Med 1995;36:378-383.
65. Elble RJ. Animal models of action tremor. Mov Disord 1998; 13:35-39.
66. Elble RJ. Tremor in ostensibly normal elderly people. Mov Disord 1998;13:457-464.
67. Elble RJ, Higgins C, Moody CJ. Stretch reflex oscillations and essential tremor. J Neurol Neurosurg Psychiatry 1987; 50:691-698.
68. Elble RJ, Koller WC. Tremor. Baltimore: Johns Hopkins University Press; 1990.
69. Elble RJ, Randall JE. Motor-unit activity responsible for 8-to 12-Hz component of human physiological finger tremor. J Neurophysiol 1976;39:370-383.
70. Elble RJ, Schieber MH, Thach WT Jr. Activity of muscle spindles, motor cortex and cerebellar nuclei during action tremor. Brain Res 1984;323:330-334.
71. Fahn S. Cerebellar tremor: clinical aspects. In: Findley LJ, Capildeo R, editors. Movement disorders: tremor. London: Macmillan; 1984.
72. Farmer SF, Sheean GL, Mayston MJ, Rothwell JC, Marsden CD, Conway BA, Halliday DM, Rosenberg JR, Stephens JA. Abnormal motor unit synchronization of antagonist muscles underlies pathological co-contraction in upper limb dystonia. Brain 1998;121:801-814.
73. Farrer M, Gwinn-Hardy K, Muenter M, DeVrieze FW, Crook R, Perez-Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Hum Mol Genet 1999;8:81-85.
74. Feingold A, Nini A, Raz A, Zelenskaya V, Bergman H. Functional connectivity and information processing in the basal ganglia of normal and parkinsonian monkeys. In: Ohye C, editor. The basal ganglia V. New York: Plenum Press; 1996.
75. Ferbert A, Gerwig M. Tremor due to stroke. Mov Disord 1993;8:179-182.
76. Fernandez HH, Friedman JH, Centofanti JV. Benedikt's sydrome with delayed-onset rubral tremor and hemidystonia: a complication of lic douloureux surgery. Mov Disord 1999; 14:695-697.
77. Findley JL, Koller WC. Handbook of tremor disorders. New York: Marcel Dekker; 1995.
78. Findley LJ, Capildeo R, editors. Movement disorders: tremor. London: Macmillan; 1984.
79. Flament D, Hore J. Comparison of cerebellar intention tremor under isotonic and isometric conditions. Brain Res 1988;439:179-186.
80. Flament D, Hore J. Movement and electromyographic disorders associated with cerebellar dysmetria. J Neurophysiol 1986;55:1221-1233.
81. Flament D, Vilis T, Hore J. Dependence of cerebellar tremor on proprioceptive but not visual feedback. Exp Neurol 1984; 84:314-325.
82. Foley TH, Marsden CD, Owen DA. Evidence for a direct peripheral effect of adrenaline on physiological tremor in man. J Physiol (Lond) 1967;189:65P-66P.
83. Freund HJ. Motor unit and muscle activity in voluntary motor control. Physiol Rev 1983;63:387-436.
84. Friedemann HH, Noth J, Diener HC, Bacher M. Long latency EMG responses in hand and leg muscles: cerebellar disorders. J Neurol Neurosurg Psychiatry 1987;50:71-77.
85. Friedman JH. "Rubral" tremor induced by a neuroleptic drug. Mov Disord 1992;7:281-282.
86. Fukuhara T, Gotoh M, Asari S, Ohmoto T. Magnetic resonance imaging of patients with intention tremor. Comput Med Imag Graph 1994;18:45-51.
87. Gabellini AS, Martinelli P, Gulli MR, Ambrosetto G, Ciucci G, Lugaresi E. Orthostatic tremor: essential and symptomatic cases. Acta Neurol Scand 1990;81:113-117.
88. Gates PC. Orthostatic tremor (shaky legs syndrome). Clin Exp Neurol 1993;30:66-71.
89. Gelenberg AJ, Jefferson JW. Lithium tremor. J Clin Psychiatry 1995;56:283-287.
90. Ghika J, Bogousslavsky J, Henderson J, Maeder P, Regli F. The "jerky dystonic unsteady hand": a delayed motor syndrome in posterior thalamic infarctions. J Neurol 1994;241: 537-542.
91. Gilman S, Carr D, Hollenberg J. Limb trajectories after cerebellar ablation and deafferentation in the monkey. Trans Am Neurol Assoc 1976;101:168-170.
92. Goto N, Kakimi S, Kaneko M. Olivary enlargement: stage of initial astrocytic changes. Clin Neuropathol 1988;7:39-43.
93. Goto N, Kaneko M. Olivary enlargement: chronological and morphometric analyses. Acta Neuropathol (Berl) 1981;54: 275-282.
94. Gulcher JR, Jonsson P, Kong A, Kristjansson K, Frigge ML, Karason A, Einarsdottir IE, Stefansson H, Einarsdottir AS, Sigurthoardottir S, Baldursson S, Bjornsdottir S, Hrafnkelsdottir SM, Jakobsson F, Benedickz J, Stefansson K. Mapping of a familial essential tremor gene, FETI, to chromosome 3q13. Nat Genet 1997;17:84-87.
95. Hallett M. Is dystonia a sensory disorder? Ann Neurol 1995; 38:139-140.
96. Hallett M, Dubinsky RM. Glucose metabolism in the brain of patients with essential tremor. J Neurol Sci 1993;114:45-48.
97. Hallett M, Shahani BT, Young RR. EMG-analysis of stereotyped voluntary movements in man. J Neurol Neurosurg Psychiatry 1975;38:1154-1162.
98. Halliday DM, Conway BA, Farmer SF, Rosenberg JR. Using electroencephalography to study functional coupling between cortical activity and electromyograms during voluntary contractions in humans. Neurosci Lett 1998;241:5-8.
99. Hassler R, Mundinger F, Riechert T. Pathophysiology of tremor at rest derived from the correlation of anatomical and clinical data. Conf Neurol 1970;32:79-87.
100. Hefter H, Homberg V, Reiners K, Freund HJ. Stability of frequency during long-term recordings of hand tremor. Electroencephalogr Clin Neurophysiol 1987;67:439-446.
101. Heilman KM. Orthostatic tremor. Arch Neurol 1984;41: 880-881.
102. Hellwig B, Hausler S, Lauk M, Guschlbauer B, Koster B, Kristeva-Feige R, Timmer J, Lucking CH. Tremor-correlated cortical activity detected by electroencephalography. Clin Neurophysiol 2000;111:806-809.
103. Henry EW, Cowen JS, Sidman RL. Comparison of Trembler and Trembler-J mouse phenotypes: varying severity of peripheral hypomyelination. J Neuropathol Exp Neurol 1983; 42:688-706.
104. Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord 1997; 12:859-864.
105. Hirsch EC, Mouatt A, Faucheux B, Bonnet AM, Javoy AF, Graybiel AM, Agid Y, Dopamine, tremor, and Parkinson's disease. Lancet 1992;340:125-126.
106. Holmes G. On certain tremors in organic cerebral lesions. Brain 1904;27:327-375.
107. Hömberg V, Hefter H, Reiners K, Freund HJ. Differential effects of changes in mechanical limb properties on physiological and pathological tremor. J Neurol Neurosurg Psychiatry 1987;50:568-579.
108. Hore J, Flament D. Evidence that a disordered servo-like mechanism contributes to tremor in movements during cerebellar dysfunction. J Neurophysiol 1986;56:123-136.
109. Hore J, Wild B, Diener HC. Cerebellar dysmetria at the elbow, wrist, and fingers. J Neurophysiol 1991;65:563-571.
110. Hughes AJ, Lees AJ, Marsden CD. Paroxysmal dystonic head tremor. Mov Disord 1991;6:85-86.
111. Hurtado JM, Gray CM, Tamas LB, Sigvardt KA. Dynamics of tremor-related oscillations in the human globus pallidus: a single case study. Proc Natl Acad Sci USA 1999;96: 1674-1679.
112. Jacks A, Prochazka A, Trend PS. Instability in human forearm movements studied with feed-back-controlled electrical stimulation of muscles. J Physiol (Lond) 1988;402:443-461.
113. Jahnsen H, Llinas R. Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro. J Physiol (Lond) 1984;349:227-247.
114. Jankovic J, Leder S, Warner D, Schwartz K. Cervical dystonia: clinical findings and associated movement disorders. Neurology 1991;41:1088-1091.
115. Jankovic J, McDermott M, Carter J, Gauthier S, Goetz C, Golbe L, Huber S, Koller W, Olanow C, Shoulson I, et al. Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology 1990;40:1529-1534.
116. Jankovic J, Van der Linden C. Dystonia and tremor induced by peripheral trauma: predisposing factors. J Neurol Neurosurg Psychiatry 1988;51:1512-1519.
117. Jedynak CP, Bonnet AM, Agid Y. Tremor and idiopathic dystonia. Mov Disord 1991;6:230-236.
118. Jellinger KA. Post mortem studies in Parkinson's disease -is it possible to detect brain areas for specific symptoms? J Neural Transm 1999;56(suppl):1-29.
119. Jenkins IH, Bain PG, Colebatch JG, Thompson PD, Findley LJ, Frackowiak RS, Marsden CD, Brooks DJ. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol 1993;34: 82-90.
120. Jung R. Physiologische Untersuchungen über den Parkinsontremor und andere Zitterformen beim Menschen. Zsch Neurol Psychiatry 1941;173:263-332.
121. Kane S, Thach W. Palatal myoclonus and function of the inferior olive: are they related. In: Strata P, editror. The olivocerebellar system in motor control. Berlin: Springer; 1989.
122. Kilner JM, Baker SN, Salenius S, Jousmaki V, Hari R, Lemon RN. Task-dependent modulation of 15-30 Hz coherence between rectified EMGs from human hand and forearm muscles. J Physiol (Lond) 1999;516:559-570.
123. Kim YJ, Pakiam AS, Lang AE. Historical and clinical features of psychogenic tremor: a review of 70 cases. Can J Neurol Sci 1999;26:190-195.
124. Kinney HC, Sidman RL. Pathology of the spongiform encephalopathy in the Gray tremor mutant mouse. J Neuropathol Exp Neurol 1986;45:108-126.
125. Klien H. Zur Pathologic der kontinuierlichen rhthmischen Krämpfe der Schlingmuskulatur (2 Fālle von Erweichungsherden im Kleinhirn). Neurol Centralbl 1907;26:245-246.
126. Koeppen AH, Barron KD, Dentinger MP. Olivary hypertrophy: histochemical demonstration of hydrolytic enzymes. Neurology 1980;30:471-480.
127. Koller W, Lang A, Vetere OB, Findley L, Cleeves L, Factor S, Singer C, Weiner W. Psychogenic tremors. Neurology 1989; 39:1094-1099.
128. Koller W, O'Hara R, Dorus W, Bauer J. Tremor in chronic alcoholism. Neurology 1985;35:1660-1662.
129. Köster B, Lank M, Timmer J, Poersch M, Guschlbauer B, Deuschl G, Lucking CH. Involvement of cranial muscles and high intermuscular coherence in orthostatic tremor. Ann Neurol 1999;45:384-388.
130. Köster B, Lauk M, Timmer J, Winter T, Guschlbauer B, Glocker FX, Danek A, Deuschl G, Lucking CH. Central mechanisms in human enhanced physiological tremor. Neurosci Lett 1998;241:135-138.
131. Krack P, Deuschl G, Kaps M, Warnke P, Schneider S, Traupe H. Delayed onset of "rubral tremor" 23 years after brainstem trauma. Mov Disord 1994;9:240-242.
132. Krack P, Hamel W, Mehdorn HM, Deuschl G. Surgical treatment of Parkinson's disease. Curr Opin Neurol 1999;12: 417-425.
133. Krauss JK, Wakhloo AK, Nobbe F, Trankle R, Mundinger F, Seeger W. Lesion of dentatothalamic pathways in severe post-traumatic tremor. Neurol Res 1995;17:409-416.
134. Kretschmer E. Die Gesetze der willkürlichen Reflexverstärkung in ihrer Bedeutung für das Hysterie- und Simulationsproblem. Zsch Neurol Psychiatry 1918;41:354-385.
135. Lapresle J. Palatal myoclonus. Adv Neurol 1986;43:265-273.
136. Lapresle J. Rhythmic palatal myoclonus and the dentatoolivary pathway. J Neurol 1979;220:223-230.
137. Lapresle J, Ben Hamida M. A contribution to the knowledge of the dento-olivary pathway. Anatomical study of 2 cases of hypertrophic degeneration of the olivary nucleus following limited softening of the tegmentum mesencephali. Presse Med 1968;76:1226-1230.
138. Lapresle J, Hamida MB. The dentato-olivary pathway. Somatotopic relationship between the dentate nucleus and the contralateral inferior olive. Arch Neurol 1970;22:135-143.
139. Lauk M, Koster B, Timmer J, Guschlbauer B, Deuschl G, Lucking CH. Side-to-side correlation of muscle activity in physiological and pathological human tremors. Clin Neurophysiol 1999;110:1774-1783.
140. Lee MS, Marsden CD. Movement disorders following lesions of the thalamus or subthalamic region. Mov Disord 1994;9: 493-507.
141. Lefebre-D'Amour M, Shahani BT, Young RR. Tremor in alcoholic patients. Prog Clin Neurophysiol 1978;5:160-164.
142. Lewin L. Untersuchungen über Banisteria caapi Sp. (Ein südamerikanisches Rauschmittel). Arch Exp Pathol Pharmacol 1928;129:133-149.
143. LeWitt PA. Orthostatic tremor: the phenomenon of 'paradoxical clonus.' Arch Neurol 1990;47:501-502.
144. Lippold OC. Oscillation in the stretch reflex arc and the origin of the rhythmical, 8-12 c/s component of physiological tremor. J Physiol (Lond) 1970;206:359-382.
145. Llinas R. Rebound excitation as the physiological basis for tremor: a biophysical study of the oscillatory properties of mammalian central neurons in vitro. In: Findley LJ, Capildeo R, editors. Movement disorders: tremor. London: Macmillan; 1984.
146. Llinas R, Baker R, Sotelo C. Electrotonic coupling between neurons in cat inferior olive. J Neurophysiol 1974;37: 560-571.
147. Llinas R, Yarom Y. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J Physiol (Lond) 1981;315: 549-567.
148. Lou JS, Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology 1991;41:234-238.
149. Louis ED, Tang MX, Cote L, Alfaro B, Mejia H, Marder K. Progression of parkinsonian signs in Parkinson disease. Arch Neurol 1999;56:334-337.
150. Lucking CH, Koster B, Guschlbauer B, Lauk M, Timmer J. Parkinsonian and essential tremors: different entities or different manifestations of the same disorder? Adv Neurol 1999;80:335-339.
151. Makela JP, Hari P, Karhu J, Salmelin R, Teravainen H. Suppression of magnetic mu rhythm during parkinsonian tremor. Brain Res 1993;617:189-193.
152. Manto MU, Setta F, Legros B, Jacquy J, Godaux E. Resetting of orthostatic tremor associated with cerebellar cortical atrophy by transcranial magnetic stimulation. Arch Neurol 1999;56:1497-1500.
153. Marsden CD. Origins of normal and pathologic tremor. In: Findley LJ, Capildeo R, editors. Movement disorders: tremor. London: Macmillan; 1984.
154. Marsden CD. The pathophysiology of movement disorders. Neurol Clin 1984;2:435-459.
155. Marsden CD, Gimlette TM, McAllister RG, Owen DA, Miller TN. Effect of beta-adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients. Acta Endocrinol (Copenh) 1968;57:353-362.
156. Marsden CD, Meadows JC. The effect of adrenaline on the contraction of human muscle-one mechanism whereby adrenaline increases the amplitude of physiological tremor. J Physiol (Lond) 1968;194:70P-71P.
157. Marsden CD, Meadows JC, Lange GW, Watson RS. The role of the ballistocardiac impulse in the genesis of physiological tremor. Brain 1969;92:647-662.
158. Masucci EF, Kurtzke JF, Saini N. Myorhythmia: a widespread movement disorder. Clinicopathological correlations. Brain 1984;107:53-79.
159. Mauritz KH, Schmitt C, Dichgans J. Delayed and enhanced long latency reflexes as the possible cause of postural tremor in late cerebellar atrophy. Brain 1981;104:97-116.
160. McAuley JH, Rothwell JC, Marsden CD. Frequency peaks of tremor, muscle vibration and electromyographic activity at 10 Hz, 20 Hz and 40 Hz during human finger muscle contraction may reflect rhythmicities of central neural firing. Exp Brain Res 1997;114:525-541.
161. McAuley JH, Rothwell JC, Marsden CD, Findley LJ. Electrophysiological aids in distinguishing organic from psychogenic tremor. Neurology 1998;50:1882-1884.
162. McDaniel KD, Cummings JL, Shain S. The "yips": a focal dystonia of golfers. Neurology 1989;39:192-195.
163. McManis PG, Sharbrough FW. Orthostatic tremor: clinical and electrophysiologic characteristics. Muscle Nerve 1993; 16:1254-1260.
164. Meert TF. Pharmacological evaluation of alcohol withdrawal-induced inhibition of exploratory behaviour and supersensitivity to harmine-induced tremor. Alcohol Alcohol 1994;29:91-102.
165. Meert TF, Rassnick S, Huysmans H, Peeters J, et al. Quantification of tremor sensitivity and inhibition of exploratory behaviour during alcohol withdrawal in rats. Behav Pharmacol 1992;3:601-607.
166. Meyer-Lohmann J, Conrad B, Matsunami K, Brooks VB. Effects of dentate cooling on precentral unit activity following torque pulse injections into elbow movements. Brain Res 1975;94:237-251.
167. Milanov I, Georgiev D. Writer's cramp and tremor due to brain tumor. Can J Neurol Sci 1995;22:59-61.
168. Milanov I, Toteva S, Georgiev D. Alcohol withdrawal tremor. Electromyogr Clin Neurophysiol 1996;36:15-20.
169. Miwa H, Hatori K, Kondo T, Imai H, Mizuno Y. Thalamic tremor: case reports and implications of the tremor-generating mechanism. Neurology 1996;46:75-79.
170. Montastruc JL, Llau ME, Rascol O, Senard JM. Drug-induced parkinsonism: a review. Fundam Clin Pharmacol 1994;8: 293-306.
171. Mossuto AL, Puccetti G, Castellano AE. "Rubral" tremor after thalamic haemorrhage. J Neurol 1993;241:27-30.
172. Nagaratnam N, Kalasabail G. Contralateral abolition of essential tremor following a pontine stroke. J Neurol Sci 1997; 149:195-196.
173. Nieuwboer A, De Weerdt W, Dom R, Lesaffre E. A frequency and correlation analysis of motor deficits in Parkinson patients. Disabil Rehabil 1998;20:142-150.
174. Oguztoreli MN, Stein RB. Interactions between centrally and peripherally generated neuromuscular oscillations. J Math Biol 1979;7:1-30.
175. Papa SM, Gershanik OS. Orthostatic tremor: an essential tremor variant? Mov Disord 1988;3:97-108.
176. Parent A, Hazrati L-N. Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Rev 1995;20:91-127.
177. Paulus W, Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol 1991;50:743-755.
178. Pelnár J, Das Zittern. Seine Erscheinungsformen, seine Pathogenese und klinische Bedeutung. Berlin: Springer; 1913.
179. Pennes HH, Hoch PH. Psychotomimetics, clinical and theoretical considerations: Harmine, Win-2299 and Nalline. Am J Psychiatry 1957;113:885-892.
180. Piper H. Uber den willkürlichen Muskeltetanus. Pflügers Arch 1907;119:301-338.
181. Plenz D, Kital ST. A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature 1999;400:677-682.
182. Poersch M. Orthostatic tremor: combined treatment with primidone and clonazepam. Mov Disord 1994;9:467.
183. Poersch M, Koster B. Tremor frequency shift in orthostatic tremor from low to high frequencies due to forceful muscle contractions. Muscle Nerve 1996;19:795-796.
184. Pollock LJ, Davis L. Muscle tone in Parkinsonian states. Arch Neurol Psychiatry 1930;23:303-309.
185. Prochazka A, Trend PS. Instability in human forearm movements studied with feed-back-controlled muscle vibration. J Physiol (Lond) 1988;402:421-442.
186. Raethjen J, Lindemann M, Schmaljohann H, Wenzelburger R, Pfister G, Deuschl G. Multiple oscillators are causing parkinsonian and essential tremor. Mov Disord 2000;15:84-94.
187. Raethjen J, Pawlas F, Lindemann M, Wenzelburger R. Deuschl G. Determinants of physiologic tremor in a large normal population. Clin Neurophysiol 2000;111:1825-1837.
188. Rajput AH, Rozdilsky B, Ang L, Rajput A. Clinicopathologic observations in essential tremor: report of six cases. Neurology 1991;41:1422-1424.
189. Remy P, de Recondo A, Defer G, Loc'h C, Amarenco P, Plante-Bordeneuve V, Dao-Castellana MH, Bendriem B, Cronzel C, Clanet M, et al. Peduncular 'rubral' tremor and dopaminergic denervation: a PET study. Neurology 1995;45: 472-477.
190. Richter A, Wissel J, Hartizius B, Simon D, Schelosky L, Scholz U, Poewe W, Loscher W. The "campus syndrome" in pigs: neurological, neurophysiological, and neuropharmacological characterization of a new genetic animal model of high-frequency tremor. Exp Neurol 1995;134:205-213.
191. Rivest J, Matsden CD. Trunk and head tremor as isolated manifestations of dystonia. Mov Disord 1990;5:60-65.
192. Rosenbaum F, Jankovic J. Focal task-specific tremor and dystonia: categorization of occupational movement disorders. Neurology 1988;38:522-527.
193. Sander HW, Masdeu JC, Tavoulareas G, Walters A, Zimmerman T, Chokroverty S. Orthostatic tremor: an electrophysiological analysis. Mov Disord 1998;13:735-738.
194. Sasaki H, Sudoh K, Hamada K, Hamada T, Tashiro K. Skeletal myoclonus in olivopontocerebellar atrophy: treatment with trihexyphenidyl. Neurology 1987;37:1258-1262.
195. Schwartzman RJ, Kerrigan J. The movement disorder of reflex sympathetic dystrophy. Neurology 1990;40:57-61.
196. Senderek J, Hermanns B, Bergmann C, Boroojerdi B, Bajbouj M, Hungs M, Ramaekers VT, Quasthoff S, Karch D, Schroder JM. X-linked dominant Charcot-Marie-Tooth neuropathy: clinical, electrophysiological, and morphological phenotype in four families with different connexin32 mutations. J Neurol Sci 1999;167:90-101.
197. Sheehy MP, Rothwell JC, Marsden CD. Writer's cramp. Adv Neurol 1988;50:457-472.
198. Singer W. Coherence as an organizing principle of cortical functions. Int Rev Neurobiol 1994;37:153-183.
199. Singer W. Neurobiology. Striving for coherence. Nature 1999;397:391.
200. Smith IS. The natural history of chronic demyelinating neuropathy associated with benign IgM paraproteinaemia. A clinical and neurophysiological study. Brain 1994;117: 949-957.
201. Soland VL, Bhatia KP, Volonte MA, Marsden CD. Focal task-specific tremors. Mov Disord 1996;11:665-670.
202. Sotelo C, Gotow T, Wassef M. Localization of glutamic-acid-decarboxylase-immunoreactive axon terminals in the inferior olive of the rat, with special emphasis on anatomical relations between GABAergic synapses and dendrodendritic gap junctions. J Comp Neurol 1986;252:32-50.
203. Sotelo C, Llinas R, Baker R. Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling. J Neurophysiol 1974;37:541-559.
204. Stein JF, Aziz TZ. Docs imbalance between basal ganglia and cerebellar outputs cause movement disorders? Curr Opin Neurol 1999;12:667-669.
205. Stein RB, Lee RG. Tremor and clonus. Handbook of physiology. Bethesda, MD: American Physiological Society; 1981.
206. Stein RB, Lee RG, Nichols TR. Modifications of ongoing tremors and locomotion by sensory feedback. Electroencephalogr Clin Neurophysiol 1978;34:512-519.
207. Stephens JA, Taylor A. The effect of visual feedback on physiological muscle tremor. Electroencephalogr Clin Neurophysiol 1974;36:457-464.
208. Steriade M, Deschenes M. The thalamus as a neuronal oscillator. Brain Res 1984;320:1-63.
209. Streib EW. Distal ulnar neuropathy as a cause of finger tremor: a case report. Neurology 1990;40:153-154.
210. Tass P, Rosenblum MG, Weule J, Kurths J, Pikovsky A, Volkmann J, Schnitzler A, Freund H-J. Detection of n:m phase locking from noisy data: application to magnetoencephalography. Phys Rev Lett 1998;81:3291-3294.
211. Thach WT, Goodkin HP, Keating JG. The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 1992;15:403-442.
212. Thompson PD, Rothwell JC, Day BL, Berardelli A, Dick JP, Kachi T, Marsden CD. The physiology of orthostatic tremor. Arch Neurol 1986;43:584-587.
213. Timmer J, Lauk M, Pfleger W, Deuschl G. Cross-spectral analysis of physiological tremor and muscle activity. I. Theory and application to unsynchronized electromyogram. Biol Cybernet 1998;78:349-357.
214. Timmer J, Lauk M, Pfleger W, Deuschl G. Cross-spectral analysis of physiological tremor and muscle activity. II. Application to synchronized electromyogram. Biol Cybernet 1998;78:359-368.
215. Tison F, Lecaroz J, Letenneur L, Dartigues JF. Parkinsonism and exposure
216. 123I]beta-CIT SPECT. J Neurol 1998;245:14-20.
217. Topka H, Mescheriakov S, Boose A, Kuntz R, Hertrich I, Seydel L, Dichgans J, Rothwell J. A cerebellar-like terminal and postural tremor induced in normal man by transcranial magnetic stimulation. Brain 1999;122:1551-1562.
218. Urushitani M, Inoue H, Kawamura K, Kageyama T, Fujisawa M, Nishinaka K, Udaka F, Kameyama M. Disappearance of essential neck tremor after pontine base infarction. No To Shinkei 1996;48:753-756.
219. Vallbo AB, Wessberg J. Organization of motor output in slow finger movements in man. J Physiol (Lond) 1993;469: 673-691.
220. Vestergaard P, Amdisen A, Schou M. Clinically significant side effects of lithium treatment. A survey of 237 patients in long-term treatment. Acta Psychiatr Scand 1980;62:193-200.
221. Vidailhet M, Jedynak CP, Pollak P, Agid Y. Pathology of symptomatic tremors. Mov Disord 1998;13:49-54.
222. Vilis T, Hore J. Effects of changes in mechanical slate of limb on cerebellar intention tremor. J Neurophysiol 1977;40: 1214-1224.
223. Volkmann J, Joliot M, Mogilner A, Ioannides AA, Lado F, Fazzini E, Ribary U, Llinas R. Central motor loop oscillations in parkinsonian resting tremor revealed by magnetoencephalography. Neurology 1996;46:1359-1370.
224. Wachholder K, Haas J. Untersuchungen über organischen und nichtorganischen Tremor. Berlin: Springer; 1929.
225. Wade P, Gresty MA, Findley LJ. A normative study of postural tremor of the hand. Arch Neurol 1982;39:358-362.
226. Walker FO, McCormick G. Orthostatic tremor. Mov Disord 1991;6:266-267.
227. Wessberg J, Kakuda N. Single motor unit activity in relation to pulsatile motor output in human finger movements. J Physiol (Lond) 1999;517:273-285.
228. Wessberg J, Vallbo AB. Coding of pulsatile motor output by human muscle afferents during slow finger movements. J Physiol (Lond) 1995;485:271-282.
229. Wessberg J, Vallbo AB. Pulsatile motor output in human finger movements is not dependent on the stretch reflex. J Physiol (Lond) 1996;493:895-908.
230. Wills AJ, Brusa L, Wang HC, Blown P, Marsden CD. Levodopa may improve orthostatic tremor: case report and trial of treatment. J Neurol Neurosurg Psychiatry 1999;66: 681-684.
231. Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. A positron emission tomography study of cerebral activation associated with essential and writing tremor. Arch Neurol 1995;52:299-305.
232. Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study. Ann Neurol 1994;36:636-642.
233. Wills AJ, Thompson PD, Findley LJ, Brooks DJ. A positron emission tomography study of primary orthostatic tremor. Neurology 1996;46:747-752.
234. Wilms H, Sievers J, Deuschl G. Animal models of tremor. Mov Disord 1999;14:557-571.
235. Winfree AT. The geometry of biological time. New York: Springer: 1980.
236. Wissel J, Harlizuis B, Richter A, Loscher W, Schelosky L, Scholz U, Poewe W. A new tremor mutant in the Pietrain pig: an animal model of orthostatic tremor? Clinical and neurophysiological observations. Mov Disord 1997;12: 743-746.
237. Yamazaki K, Wakasugi N, Tomita T, Kikuchi T, Mukoyama M, Ando K. Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc Soc Exp Biol Med 1988; 187:209-215.
238. Yanagisawa T, Sugihara H, Shibahara K, Kamo T, Fujisawa K, Murayama M. Natural course of combined limb and palatal tremor caused by cerebellar-brain stem infarction. Mov Disord 1999;14:851-854.
239. Yeung KB, Thomas PK, King RH, Waddy H, Will RG, Hughes RA, Gregson NA, Leibowitz S. The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings. J Neurol 1991; 238:383-391.
240. Yokota T, Hirashima F, Furukawa T, Tsukagoshi H. Yoshikawa H. MRI findings of inferior olives in palatal myoclonus. J Neurol 1989;236:115-116.
241. Yokota T, Tsukagoshi H. Olivary hypertrophy precedes the appearance of palatal myoclonus. J Neurol 1991;238:408.
242. Zirh TA, Lenz FA, Reich SG, Dougherty PM. Patterns of bursting occurring in thalamic cells during parkinsonian tremor. Neuroscience 1998;83:107-121.