Abnormal motor unit synchronization of antagonist muscles underlies pathological co-contraction in upper limb dystonia

Brain

Volumn 121, Issue 5, 1998, Pages 801-814

  Farmer, S F ^a,b   Sheean, G L ^a,b   Mayston, M J ^c   Rothwell, J C ^a   Marsden, C D ^a   Conway, B A ^d   Halliday, D M ^e   Rosenberg, J R ^e   Stephens, J A ^c  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b ST MARY S HOSPITAL   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Co contraction; Dystonia; Motor unit synchronization; Tremor; Writer's cramp

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DYSTONIA; ELECTROMYOGRAM; EXTENSOR CARPI RADIALIS MUSCLE; EXTENSOR MUSCLE; FEMALE; FLEXOR CARPI RADIALIS MUSCLE; FLEXOR MUSCLE; HUMAN; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; MOTOR UNIT; MUSCLE CONTRACTION; MUSCLE CRAMP; NEUROPHYSIOLOGY; PATHOPHYSIOLOGY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; TREMOR;

ADOLESCENT; ADULT; ARM; CASE-CONTROL STUDIES; DYSTONIA; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE CRAMP; REACTION TIME;

EID: 0031921585     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/121.5.801     Document Type: Article

References (45)

1. Baker SN, Olivier E, Lemon RN. Coherent oscillations in monkey motor cortex and hand muscle EMG show task-dependent modulation. J Physiol (Lond) 1997; 501: 225-41.
2. Berardelli A, Rothwell JC, Day BL, Marsden CD. Pathophysiology of blepharospasm and oromandibular dystonia. Brain 1985; 108: 593-608.
3. Bremner FD, Baker JR, Stephens JA. Correlation between the discharges of motor units recorded from the same and from different finger muscles in man. J Physiol (Lond) 1991a; 432: 355-80.
4. Bremner FD, Baker JR, Stephens JA. Variation in the degree of synchronization exhibited by motor units lying in different finger muscles in man. J Physiol (Lond) 1991b; 432: 381-99.
5. Ceballos-Baumann AO, Passingham RE, Warner T, Playford ED, Marsden CD, Brooks DJ. Overactive prefrontal and underactive motor cortical areas in idiopathic dystonia. Ann Neurol 1995a; 37: 363-72.
6. Ceballos-Baumann AO, Passingham RE, Marsden CD, Brooks DJ. Motor reorganization in acquired hemidystonia. Ann Neurol 1995b; 37: 746-57.
7. Cohen LG, Hallett M. Hand cramps: clinical features and electromyographic patterns in a focal dystonia. Neurology 1988; 38: 1005-12.
8. Conway BA, Halliday DM, Farmer SF, Shahani U, Maas P, Weir AI, et al. Synchronization between motor cortex and spinal motoneuronal pool during the performance of a maintained motor task in man. J Physiol (Lond) 1995; 489: 917-924.
9. Datta AK, Stephens JA. Synchronization of motor unit activity during voluntary contraction in man. J Physiol (Lond) 1990; 422: 397-419.
10. Datta AK, Farmer SF, Stephens JA. Central nervous pathways underlying synchronization of human motor unit firing studied during voluntary contractions. J Physiol (Lond) 1991; 432: 401-25.
11. Farmer SF, Ingram DA, Stephens JA. Mirror movements studied in a patient with Klippel-Feil syndrome. J Physiol (Lond) 1990; 428: 467-84.
12. Farmer SF, Harrison LM, Ingram DA, Stephens JA. Plasticity of central motor pathways in children with hemiplegic cerebral palsy. Neurology 1991; 41: 1505-10.
13. Fanner SF, Swash M, Ingram DA, Stephens JA. Changes in motor unit synchronization following central nervous lesions in man. J Physiol (Lond) 1993a; 463: 83-105.
14. Farmer SF, Bremner FD, Halliday DM, Rosenberg JR, Stephens JA. The frequency content of common synaptic inputs to motoneurones studied during isometric voluntary contraction in man. J Physiol (Lond) 1993b; 470: 127-55.
15. Farmer SF, Sheean G, Rothwell JC, Marsden CD. Abnormal motor unit synchronisation between antagonist muscles in dystonia [abstract]. J Neurol Neurosurg Psychiatry 1995; 59: 208-9.
16. Fetz EE, Cheney PD, Mewes K, Palmer S. Control of forelimb muscle activity by populations of corticomotoneuronal and rubromotoneuronal cells. [Review]. Prog Brain Res 1989; 80: 437-49.
17. Gibbs J, Harrison LM, Mayston MJ, Stephens JA. Short-term anti-synchronization of motor unit activity in antagonistic muscles in man. J Physiol (Lond) 1994; 476P: 20-1P.
18. Harrison LM, Ironton R, Stephens JA. Cross-correlation analysis of multi-unit EMG recordings in man. J Neurosci Methods 1991; 40: 171-9.
19. Hughes M, McLellan DL. Increased co-activation of the upper limb muscles in writer's cramp. J Neurol Neurosurg Psychiatry 1985: 48: 782-7.
20. Ikoma K, Samii A, Mercuri B, Wassermann EM, Hallett M. Abnormal cortical motor excitability in dystonia. Neurology 1996; 46: 1371-6.
21. Kirkwood PA, Sears TA. The synaptic connexions to intercostal motoneurones as revealed by the average common excitation potential. J Physiol (Lond) 1978; 275: 102-34.
22. Kirkwood PA, Sears TA, Tuck DL, Westgaard RH. Variations in the time course of the synchronization of intercostal motoneurones in the cat. J Physiol (Lond) 1982a; 327: 105-35.
23. Kirkwood PA, Sears TA, Stagg D, Westgaard RH. The spatial distribution of synchronization of intercostal motoneurones in the cat. J Physiol (Lond) 1982b; 327: 137-55.
24. Kirkwood PA, Sears TA, Westgaard RH. Restoration of function in external intercostal motoneurones of the cat following partial central deafferentation. J Physiol (Lond) 1984; 350: 225-51.
25. Lee MS, Marsden CD. Movement disorders following lesions of the thalamus or subthalamic region. [Review]. Mov Disord 1994; 9: 493-507.
26. Marsden CD, Sheehy MP. Writer's cramp. [Review]. Trends Neurosci 1990; 13: 148-53.
27. Marsden CD, Obeso JA, Zarranz JJ, Lang AE. The anatomical basis of symptomatic hemidystonia. Brain 1985; 108: 463-83.
28. Matsumura M, Sawaguchi T, Oishi T, Ueki K, Kubota K. Behavioral deficits induced by local injection of bicuculline and muscimol into the primate motor and premotor cortex. J Neurophysiol 1991; 65: 1542-53.
29. Mink JW, Thatch WT. Basal ganglia motor control III. Pallidal ablation: Normal reaction time, muscle cocontraction, and slow movement. J Neurophysiol 1991; 65: 330-51.
30. Murthy VN, Fetz EE. Oscillatory activity in sensorimotor cortex of awake monkeys: synchronization of local field potentials and relation to behavior. J Neurophysiol 1996a; 76: 3949-67.
31. Murthy VN, Fetz EE. Synchronization of neurons during local field potential oscillations in sensorimotor cortex of awake monkeys. J Neurophysiol 1996b; 76: 3968-82.
32. Nakashima K, Rothwell JC, Day BL, Thompson PD, Shannon K, Marsden CD. Reciprocal inhibition between forearm muscles in patients with writer's cramp and other occupational cramps, symptomatic hemidystonia and hemiparesis due to stroke. Brain 1989; 112: 681-97.
33. Naumann M, Reiners K. Long-latency reflexes of hand muscles in idiopathic focal dystonia and their modification by botulinum toxin. Brain 1997; 120: 409-16.
34. Nielsen J, Kagamihara Y. The regulation of disynaptic reciprocal Ia inhibition during co-contraction of antagonistic muscles in man. J Physiol (Lond) 1992; 456: 373-91.
35. Nielsen J, Kagamihara Y. Synchronization of human leg motor units during co-contraction in man. Exp Brain Res 1994; 102: 84-94.
36. Panizza ME, Hallett M, Nilsson J. Reciprocal inhibition in patients with hand cramps. Neurology 1989; 39: 85-9.
37. Pettigrew LC, Jankovic J. Hemidystonia: a report of 22 patients and a review of the literature. J Neurol Neurosurg Psychiatry 1985; 48: 650-7.
38. Reilly JA, Hallen M, Cohen LG, Tarkka IM, Dang N. The N30 component of somatosensory evoked potentials in patients with dystonia. Electroencephalogr Clin Neurophysiol 1992; 84: 243-7.
39. Ridding MC, Sheean G, Rothwell JC, Inzelberg R, Kujirai T. Changes in the balance between motor cortical excitation and inhibition in focal task specific dystonia. J Neurol Neurosurg Psychiatry 1995; 59: 493-8.
40. Rosenberg JR, Amjad AM, Breeze P, Brillinger DR, Halliday DM. The Fourier approach to the identification of functional coupling between neuronal spike trains. [Review]. Prog Biophys Mol Biol 1989; 53: 1-31.
41. Rothwell JC, Obeso JA, Day BL, Marsden CD. Pathophysiology of dystonias. Adv Neurol 1983; 39: 851-63.
42. Sears TA, Stagg D. Short-term synchronization of intercostal motoneurone activity. J Physiol (Lond) 1976; 263: 357-81.
43. Tatton WG, Bedingham W, Verrier MC, Blair RD. Characteristic alterations in responses to imposed wrist displacements in parkinsonian rigidity and dystonia musculorum deformans. Can J Neurol Sci 1984; 11: 281-7.
44. Tuck DL. Investigation of intercostal neuronal intracellular processes and connectivity by signal analysis and computer simulation [PhD thesis]. London: University of London; 1977.
45. van der Kamp W, Berardelli A, Rothwell JC, Thompson PD, Day BL, Marsden CD. Rapid elbow movements in patients with torsion dystonia. J Neurol Neurosurg Psychiatry 1989; 52: 1043-9.