Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity

Cardiovascular Research

Volumn 51, Issue 1, 2001, Pages 108-121

  Stamm, Christof ^a   Friehs, Ingeborg ^a   Cowan, Douglas B ^a   Cao Danh, Hung ^a   Noria, Sabrena ^b   Munakata, Mamoru ^a   McGowan Jr , Francis X ^a   Del Nido, Pedro J ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Calcium (cellular); Contractile function; E c coupling; Ischemia; Protein kinases; Reperfusion

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALCIUM ION; CHELERYTHRINE; ISOPROTEIN; PROTEIN KINASE C;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART EXCITATION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR TRANSPORT; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; RABBIT; WESTERN BLOTTING;

ALKALOIDS; ANALYSIS OF VARIANCE; ANIMALS; BENZOPHENANTHRIDINES; BLOTTING, WESTERN; CALCIUM; CONTRACTILE PROTEINS; DIASTOLE; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INDOLES; ISOENZYMES; MALEIMIDES; MICROSCOPY, CONFOCAL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; PHENANTHRIDINES; PROTEIN KINASE C; RABBITS;

EID: 0035005389     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00249-8     Document Type: Article

References (46)

1. Myocardial stunning and hibernation: The physiology behind the colloquialisms
2. Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament responsiveness and altered diastolic function in intact ventricular muscle
3. Altered calcium sensitivity of isometric tension in myocyte-sized preparations of porcine postischemic myocardium
4. 2+ modulation during postischemic reperfusion in rat heart
5. Protein kinase C activation in the heart: Effects on calcium and contractile proteins
6. Tonic regulation of excitation-contraction coupling by basal protein kinase C activity in isolated cardiac myocytes
7. 2+-stimulated actomyosin MgATPase activity
8. 2+-stimulated MgATPase activity in reconstituted actomyosin and isolated myofibrils, and decreases actin-myosin interactions
9. Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponine I and its phosphorylation site mutants
10. Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase
11. 1-receptor-independent activation of protein kinase C in acute myocardial ischemia
12. Protein kinase C activation is protective in the ischemic heart
13. Postischemic function and protein kinase C signal transduction
14. Protein kinase C activation before cardioplegic arrest: Beneficial effects on myocyte contractility
15. 2+ induced cardioadaptation to ischemia-reperfusion injury
16. Cardiac preconditioning with calcium: Clinically accessible myocardial protection
17. + current in human and rabbit ventricular myocytes
18. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery
19. Fluorescence measurement of calcium transients in perfused rabbit heart using rhod-2
20. 2+
21. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function
22. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia
23. Adenosine prevents protein kinase C activation during hypothermic ischemia
24. Ischemic preconditioning translocates PKC-δ and ε, which mediate functional protection in isolated rat heart
25. Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia
26. 2+ overload injury in rat myocardium
27. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity
28. Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes
29. 2+ in adult rat cardiac myocytes
30. 2+ sensitivity in intact and skinned muscles from normal and diseased human myocardium
31. Activation of ε protein kinase C correlates with a cardioprotective effect of ethanol consumption
32. 2+ and pH in positive inotropic response of cardiomyocytes to diacylglyerol
33. Effects of protein kinase C inhibitors in in situ and isolated ischemic rabbit myocardium
34. Preconditioning of isolated rat heart is mediated by protein kinase C
35. Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart
36. The PKC activator PMA preconditions rabbit heart in the presence of adenosine receptor blockade: Is 5′-nucleotidase important?
37. Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells
38. Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase
39. Troponin I phosphorylation in the normal and failing adult human heart
40. Contractile proteins in globally stunned rabbit myocardium
41. 2+ of myofibrils isolated from stunned and non-stunned porcine myocardium
42. Role of troponin I proteolysis in the pathogenesis of stunned myocardium
43. Breakdown and release of myofilament proteins during ischemia/reperfusion in rat hearts: Identification of degradation products and effects on the pCa-force relation
44. Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury
45. Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of β-isoform of protein kinase C in rat ventricular myocardium