In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei

American Journal of Pathology

Volumn 158, Issue 5, 2001, Pages 1579-1584

  Valent, Alexander ^a,e   Bénard, Jean ^c   Clausse, Bernard ^b   Barrois, Michel ^c   Valteau Couanet, Dominique ^e   Terrier Lacombe, Marie José ^d   Spengler, Barbara ^f   Bernheim, Alain ^a,b  

^a CNRS   (France)

^b Lab de Cytogénétique   (France)

^c Unité des Marqueurs Génétiques des Cancers   (France)

^d Département d'Anatomopathologie   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f FORDHAM UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYUREA;

ARTICLE; CHILD; CLINICAL ARTICLE; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFANT; MICRONUCLEUS; NEUROBLASTOMA; ONCOGENE; ONCOGENE MYCN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TUMOR CELL;

EID: 0035004854     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64112-0     Document Type: Article

References (37)

1. Prognostic factors in neuroblastoma
2. Molecular basis for heterogeneity in human neuroblastomas
3. Molecular analysis and clinical significance of N-myc amplification and chromosome 1 abnormalities in human neuroblastomas
4. Amplified DNA domain with limited homology to the myc cellular oncogene is shared by human neuroblastoma cell lines and a human neuroblastoma tumor
5. Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis
6. Additional copies of a 25 Mb chromosomal region originating from 17q23.1-17qter are present in 90% of high-grade neuroblastomas
7. Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma
8. N-myc gene amplification is a major prognostic factor in localized neuroblastoma: Results of the French NLB90 study
9. Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy and histology in 110 infants with stage D(S) neuroblastoma: The Pediatric Oncology Group experience
10. Targeted expression of MYCN causes neuroblastoma in transgenic mice
11. Gene amplification in human cancers: Biological and clinical significance
12. Preferential loss of chromosomes containing amplified DNA regions in cultured cells
13. Elimination of extrachromosomally amplified myc genes from human tumor cells reduces their tumorigenicity
14. Neuroblastoma cells can actively eliminate supernumerary MYCN gene copies by micronucleus formation - Sign of tumor cell revertance?
15. Loss of amplified c-myc genes in the spontaneously differentiated HL-60 cells
16. Induction of differentiation in HL-60 cells by the reduction of extrachromosomally amplified c-myc
17. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronuclei during S phase
18. The advantages and disadvantages of the cytokines-block micronucleus method
19. Micronuclei: A biological indicator of radiation damage
20. Phenotypic and genotypic diversity of human neuroblastoma studied in 3 IGR cell lines models derived from bone marrow metastasis
21. Oncogene amplification in solid tumors
22. Replication timing control can be maintained in extrachromosomally amplified genes
23. Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei
24. Expulsion of amplified MYCN from neuroblastoma tumor cells
25. Analysis of the DNA content distribution of micronuclei using flow sorting and fluorescent in situ hybridization with a centromeric DNA probe
26. A case of elevated spontaneous micronucleus frequency derived from chromosome 2
27. Indications for a threshold of chemically induced aneuploidy in vitro in human lymphocytes
28. The frequency and distribution of apoptosis induced by three non-carcinogenic agents in mouse colonic crypts
29. Nuclear architecture and the induction of chromosomal aberrations
30. Organization of early and late replicating DNA in human chromosome territories
31. Spatial distribution of GC- and AT-rich DNA sequences within human chromosome territories
32. Hydroxyurea accelerates the loss of epidermal growth factor receptor genes amplified as double minute chromosomes in human glioblastoma multiforme
33. Use of hydroxyurea to alter drug resistance of human tumor cells
34. Prognostic significance of MYCN oncogene expression in childhood neuroblastoma
35. Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse
36. Pleiotropic over-expression of multidrug-resistance-related gene is correlated to MYCN and max mRNA accumulation in the IGR-N91 human neuroblastoma model
37. Altered expression of MYCN oncogene, MRP gene expression and response to cytotoxic drugs in neuroblastoma cells