Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia

American Journal of Cardiology

Volumn 80, Issue 3 A, 1997, Pages 11A-16A

  Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE; MALONYL COENZYME A;

CONFERENCE PAPER; ENZYME INHIBITION; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0030860259     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(97)00453-0     Document Type: Conference Paper

References (58)

1. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1213:1994;263-276.
2. Neely JR, Morgan HE. Relationship between carbohydrate metabolism and energy balance of heart muscle. Annu Rev Physiol. 36:1974;413-459.
3. Saddik M, Lopaschuk GD. Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem. 266:1991;8162-8170.
4. Oliver MF, Opie LH. Effects of glucose and fatty acid acids on myocardial ischaemia and arrhythmias. Lancet. 343:1994;155-158.
5. Schwaiger M, Schelbert HR, Ellison D, Hansen H, Yeatman L, Vinten-Johansen J, Selin C, Barrio J, Phelps ME. Sustained regional abnormalities in cardiac metabolism after transient ischemia in the chronic dog model. J Am Coll Cardiol. 6:1985;336-347.
6. Liu B, El Alaoui-Talibi Z, Clanachan AS, Schulz R, Lopaschuk GD. Uncoupling of contractile function from mitochondrial tricarboxylic acid cycle activity and oxygen consumption during reperfusion of ischemic rat hearts. Am J Physiol. 270:1996;H72-H80.
7. Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res. 79:1996;940-948.
8. Lopaschuk GD, Spafford M, Davies NJ, Wall SR. Glucose and palmitate oxidation in isolated working rat hearts reperfused following a period of transient global ischemia. Circ Res. 66:1989;546-553.
9. Liedtke AJ, DeMaison L, Eggelston AM, Cohen LM, Nekkis SH. Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res. 62:1988;535-542.
10. Benzi RH, Lerch R. Dissociation between contractile function and oxidative metabolism in postischemic myocardium. Circ Res. 71:1992;567-576.
11. Saddik M, Lopaschuk GD. Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia. J Biol Chem. 267:1991;3825-3831.
12. Oliver MR, Kurien VA, Greenwood TW. Relation between serum-free-fatty acid and arrhythmia and death after myocardial infarction. Lancet. 1:1968;710-715.
13. Allison SP, Chamberlain MJ, Hinton P. Intravenous glucose tolerance, insulin, glucose and free fatty acid levels after myocardial infarction. Br Med J. 4:1969;776-778.
14. Mueller HS, Ayres ST. Metabolic responses of the heart in acute myocardial infarction in man. Am J Cardiol. 42:1978;363-371.
15. Lopaschuk GD, Collins-Nakai R, Olley PM, Montague TJ, McNeil G, Gayle M, Penkoske P, Finegan BA. Plasma fatty acid levels in infants and adults after myocardial ischemia. Am Heart J. 128:1994;61-67.
16. Svensson S, Svedjeholm R, Ekroth R, Milocco I, Nilsson F, Sabel KG, William-Olsson G. Trauma metabolism and the heart: uptake of substrates and effects of insulin early after cardiac operations. J Thorac Cardiovasc Surg. 99:1990;1063-1073.
17. McGarry JD, Leatherman GF, Foster DW. Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. J Biol Chem. 253:1978;4128-4136.
18. McGarry JD, Woeltje KF, Kuwajima M, Foster DW. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes. 5:1989;271-284.
19. Saddik M, Gamble J, Witters LA, Lopaschuk GD. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. J Biol Chem. 268:1993;25836-25845.
20. Lopaschuk G, Witters LA, Itoi T, Barr R, Barr A. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. J Biol Chem. 269:1994;25871-25878.
21. Kudo N, Barr A, Barr R, Lopaschuk GD. 5′-AMP-activated protein kinase inhibition of acetyl CoA carboxylase can explain the high rates of fatty acid oxidation in reperfused ischemic hearts. J Biol Chem. 270:1995;17511-17520.
22. Kudo N, Gillespie JG, Kung L, Witters LA, Schulz R, Clanachan AS, Lopaschuk GD. Characterization of 5′-AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim Biophys Acta. 1301:1996;67-75.
23. Hardie DG. Regulation of fatty acid synthesis via phosphorylation of acetyl CoA-carboxylase. Prog Lipid Res. 28:1989;117-146.
24. Kim KH, Lopez-Casillas F, Bai DH, Luo X, Pape ME. Role of reversible phosphorylation of acetyl-CoA carboxylase in long-chain fatty acid synthesis. FASEB J. 3:1989;2250-2256.
25. Bianchi A, Evans JL, Iverson AJ, Nordlund A, Watts TD, Witters LA. Identification of an isozymic form of acetyl-CoA carboxylase. J Biol Chem. 265:1990;1502-1509.
26. Thampy KG. Formation of malonyl-CoA in rat heart. J Biol Chem. 264:1989;17631-17634.
27. Hardie DG. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. Biochim Biophys Acta. 1123:1992;231-238.
28. Wins R, Hess D, Achersold R, Brownsey RW. Unique structural features and differential phosphorylation of the 280-kDa component (isozyme) of rat liver acetyl-CoA carboxylase. J Biol Chem. 269:1994;14438-14445.
29. Kudo N, Kung L, Witters LA, Hardie G, Lopaschuk GD. Heart contains an active 5′-AMP-activated protein kinase that is involved in the regulation of fatty acid oxidation. Circulation. 92:1995;51-771.
30. Hardie DG. An emerging role for protein kinases: the response to nutritional and environmental stress. Cell Signal. 6:1994;813-821.
31. Aguan K, Scott J, See CG, Sarkar NH. Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. Gene. 149:1994;345-350.
32. Beri RK, Marley AE, See CG, Sopwith WF, Aguan K, Carling D, Scott J, Carey F. Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. FEBS Lett. 356:1994;117-121.
33. Gao G, Widmer J, Stapleton D, Teh T, Cox T, Kemp BE, Witters LA. Catalytic subunits of the porcine and rat 5′-AMP-activated protein kinase are members of the SNF1 protein kinase family. Biochim Biophys Acta. 1266:1995;73-82.
34. Verhoeven AJM, Woods A, Brennan CH, Hawley SA, Hardie DG, Scott J, Beri RK, Carling D. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Eur J Biochem. 228:1995;236-243.
35. Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, The T, House CM, Fernanadex CS, Cox T, Witters LA, Kemp BE. Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 271:1996;611-614.
36. Carling D, Aguan K, Woods A, Verhoeven AJM, Beri RK, Brennan CH, Sidebottom C, Davison D, Scott J. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. J Biol Chem. 269:1994;11442-11448.
37. Woods A, Cheung PCF, Smith FC, Davisono MD, Scott J, Beri RK, Carling D. Characterizaiton of AMP-activated protein kinase β and γ subunits. J Biol Chem. 271:1996;10282-10290.
38. Dyck JRB, Gao G, Widmer J, Stapleton D, Fernandez CS, Kemp BE, Witters LA. Regulation of 5′-AMP-activate protein kinase activity by the noncatalytic β and γ subunits. J Biol Chem. 271:1996;8675-8681.
39. Weekes J, Hawley SA, Corton J, Shugar D, Hardie DG. Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Eur J Biochem. 219:1994;751-757.
40. 2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem. 270:1995;27186-27191.
41. Liedtke AJ, Nellis S, Neely JR. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res. 43:1978;652-661.
42. Lopaschuk GD, Wall SR, Olley PM, Davies NJ. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 63:1988;1036-1043.
43. Liedtke AJ, Nellis SH, Mjos OD. Effects of reducing fatty acid metabolism on mechanical function in regionally ischemic heart. Am J Physiol. 247:1984;H387-H394.
44. Mjos OD, Miller NE, Riemersma RA, Oliver MF. Effect of dichloroacetate on myocardial substrate extraction, epicardial ST-segment elevation, and ventricular blood flow following coronary occlusion in dogs. Cardiovasc Res. 10:1976;427-436.
45. McVeigh JJ, Lopaschuk GD. (1990) Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol. 259:1990;H1079-H1085.
46. Lopaschuk GD, Wambolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Ther. 264:1993;135-144.
47. Patel MS, Roche TE. Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J. 4:1990;3224-3233.
48. McCormack JG, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev 70:439-425; 1990.
49. Renstrom B, Nellis SH, Liedtke AJ. Metabolic oxidation of glucose during early myocardial reperfusion. Circ Res. 65:1989;1094-1101.
50. Racey-Burns LA, Burns AH, Sumer WR, Sheperd RE. The effect of dichloroacetate on the isolated no flow arrested rat heart. Life Sci. 44:1989;2015-2023.
51. Lewandowski ED, White TW. Pyruvate dehydrogenase influences postischemic heart function. Circulation. 91:1995;2071-2079.
52. Wahr JA, Childs KF, Bolling SF. Dichloroacetate enhances myocardial function and metabolic recovery following global ischemia. J Cardiothorac Vasc Anesth. 8:1994;192-197.
53. Randle PJ, Hales CN, Garland PB, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetic mellitus. Lancet. i:1963;785-789.
54. Stacpoole PW. The pharmacology of dichloroacetate. Metabolism. 38:1989;21124-21144.
55. Broderick TL, Quinney HA, Barker CC, Lopaschuk GD. The beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation. 87:1994;972-981.
56. Schönekess BO, Allard MF, Lopaschuk GD. Propionyl carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. Circ Res. 77:1995;726-734.
57. McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic hearts. Circulation. 93:1996;135-142.
58. Bunger R, Mallet RT, Hartman DA. Pyruvate-enhanced phosphorylation potential and inotropism I normoxic and postischemic isolated working heart: near-complete prevention of reperfusion contractile failure. Eur J Biochem. 180:1989;221-233.