Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients

European Journal of Immunology

Volumn 31, Issue 5, 2001, Pages 1438-1446

  Godkin, Andrew ^a,b   Jeanguet, Nathalie ^a   Thursz, Mark ^a   Openshaw, Peter ^a   Thomas, Howard ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cytokine; Human; Infectious immunity virus; MHC; T lymphocyte

Indexed keywords

BLOOD CLOTTING FACTOR 5; BOVINE SERUM ALBUMIN; CATHEPSIN D; ENTACTIN; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; HLA DR11 ANTIGEN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RIBOPHORIN I; SEROTONIN RECEPTOR; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL SPECIFICITY; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; PERSISTENT VIRUS INFECTION; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TIME; VIRUS CHARACTERIZATION; VIRUS INFECTION;

ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; LIGANDS; LYMPHOCYTE COUNT; PEPTIDES; SOFTWARE; VIREMIA;

EID: 0034996027     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200105)31:5<1438::AID-IMMU1438>3.0.CO;2-2     Document Type: Article

References (33)

1. Sharara, A., Hunt, C. and Hamilton, J., Hepatitis C. Ann. Intern. Med. 1996. 125: 658-668.
2. + T cells during the primary immune response to Epstein-Barr virus in vivo. J. Exp. Med. 1998. 187: 1395-1402.
3. Gallimore, A., Glithero, A., Godkin, A., Tissot, A., Pluckthun, A., Elliot, T., Hengartner, H. and Zinkernagel, R., Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualised using soluble tetrameric MHC class I / peptide complexes. J. Exp. Med. 1998. 187: 1383-1393.
4. Cooper, S., Erickson, A., Adams, E., Kansopon, J., Weiner, J., Chien, D., Houghton, M., Parham, P. and Walker, C., Analysis of a successful immune response against hepatitis C virus. Immunity 1999. 10: 439-449.
5. Lechner, F., Wong, D., Dunbar, R., Chapman, R., Chung, R., Dohrenwend, P., Robbins, G., Phillips, R., Klenerman, P. and Walker, B., Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 2000. 191: 1499-1512.
6. Ogg, G., Jin, X., Bonhoeffer, S., Dunbar, R., Nowak, M., Monard, S., Segal, J., Cao, Y., Rowland-Jones, S., Cerundolo, V. and McMichael, A., Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of RNA. Science 1998. 279: 2103-2106.
7. He, X., Rehermann, B., Lopez-Labrador, F., Boisvert, J., Cheung, R., Mumm, J., Wedemeyer, H., Berenguer, M., Wright, T., Davis, M. and Greenberg, H., Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc. Natl. Acad. Sci. USA 1999. 96: 5692-5697.
8. Kalams, S. and Walker, B., The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J. Exp. Med. 1998. 188: 2199-2204.
9. + cytotoxic T cell responses during chronic viral infection. J. Virol. 1994. 68: 8056-8063.
10. Hill, A., The immunogenetics of human infectious diseases. Annu. Rev. Immunol. 1998. 16: 593-617.
11. Zuckerman, A. and Thomas, H. (Eds.) Viral hepatitis: scientific basis and clinical management. Churchill Livingstone, 1993.
12. Lechmann, M., Ihlenfeldt, H., Braunsschweiger, I., Giers, G., Jung, G., Matz, B., Kaiser, R., Sauerbruch, T. and Spengler, U., T-and B cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viraemia. Hepatology 1996. 24: 790-795.
13. Botarelli, P., Brunetto, M., Minutello, M., Calvo, P., Unutmaz, D., Weiner, A., Choo, Q., Shuster, J., Kuo, G., Bonino, F., Houghton, M. and Abrignani, S., T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 1993. 104: 580-587.
14. Ferrari, C., Valli, A., Galati, L., Penna, A., Scaccaglia, P., Giuberti, T., Schianchi, C., Missale, G., Marin, M. and Fiaccadori, F., T cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 1994. 19: 286-295.
15. Diepolder, H., Zachoval, R., Hoffmann, R., Wierenga, E., Santantonio, T., Jung, M., Eichenlaub, D. and Pape, G., Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995. 346: 1006-1007.
16. +T cell response in acute hepatitis C. Gastroenterology 1999. 117: 933-941.
17. Takaki, A., Wiese, M., Maertens, G., Depla, E., Seifert, U., Liebetrau, A., Miller, J., Manns, M. and Rehermann, B., Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 2000. 6: 578-582.
18. Koziel, M., N., D., Afdal, N., Grakoui, A., Rice, C., Choo, Q., Houghton, M. and Walker, B., HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. J. Clin. Inv. 1995. 96: 2311-2321.
19. Rehermann, B., Chang, K., McHutchison, J., Kokka, R., Houghton, M. and Chisari, F., Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J. Clin. Invest. 1996. 98: 1432-1440.
20. McMichael, A. and O'Callaghan, C., A new look at T cells. J. Exp. Med. 1998. 187: 1367-1371.
21. Rammensee, H.-G., Chemistry of peptides associated with MHC class I and class II molecules. Curr. Opin. Immunol. 1995. 7: 85-96.
22. Davenport, M., Ho Shon, I. and Hill, A., An empirical method for the prediction of T cell epitopes. Immunogenetics 1995. 42: 392-397.
23. Godkin, A., Davenport, M., Willis, A., Jewell, D. and Hill, A., Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the non-binding terminal regions of ligands in epitope selection. J. Immunol. 1998. 161: 850-858.
24. Verreck, F., van-de-Poel, A., Drijfhout, J., Amons, R., Coligan, J. and Konig, F., Natural peptides isolated from Gly86/Val86-containing variants of HLA-DR1, -DR11, -DR13, and -DR52. Immunogenetics 1996. 43: 392-397.
25. + T cell clones and resting T cells. J. Immunol. 1993. 150: 4754-4765.
26. Macatonia, S., Doherty, T., Knight, S. and O'Garra, A., Differential effect of IL-10 on dendritic cell induced T cell proliferation and IFN-γ production. J. Immunol. 1993. 150: 3755-3765.
27. Gooding, L., Virus proteins that counteract host immune responses. Cell 1992. 71: 5-7.
28. Wang, H. and Eckels, D., Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition. J. Immunol. 1999. 162: 4177-4183.
29. Buer, J., Lanoue, A., Franzke, A., Garcia, C., von Boehmer, H. and Sarukham, A., Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergised in vivo. J. Exp. Med 1998. 187: 177-183.
30. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchla, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
31. Seder, R. and Hill, A., Vaccines against intracellular infections requiring cellular immunity. Nature 2000. 406: 793-798.
32. Varga, S. and Welsh, R., Stability of virus-specific CD4 T cell frequencies from the acute infection into long term memory. J. Immunol. 1998. 161: 367-374.
33. Whitmire, J., Murali-Krishna, K., Altman, J. and Ahmed, R., Antiviral CD4 and CDS T cell memory: differences in the size of the response and activation requirements. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2000. 355: 373-379.