Mathematical model of antibody targeting: Important parameters defined using clinical data

Physics in Medicine and Biology

Volumn 46, Issue 6, 2001, Pages 1679-1693

  Green, A J ^a   Johnson, C J ^a   Adamson, K L ^a   Begent, R H J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLORECTAL CANCER;

BLOOD; MATHEMATICAL MODELS; MOLECULAR WEIGHT; PARAMETER ESTIMATION; PRESSURE EFFECTS; TUMORS;

ANTIBODIES;

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G;

ANTIBODY AFFINITY; ARTICLE; CLINICAL STUDY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG TARGETING; HUMAN; MOLECULAR MODEL; MOLECULAR WEIGHT; PARAMETER; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY;

ANTIGEN-ANTIBODY REACTIONS; CARCINOEMBRYONIC ANTIGEN; CLINICAL TRIALS; COLORECTAL NEOPLASMS; HUMANS; LIVER; MODELS, THEORETICAL; TIME FACTORS;

EID: 0034987850     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/46/6/307     Document Type: Article

References (32)

1. Radioiodination for therapy
2. Transport of fluid and macromolecules in tumors. 1. Role of interstitial pressure and convection
3. Transport of fluid and macromolecules in tumors. 4. A microscopic model of the perivascular distribution
4. Biodistribution of monoclonal-antibodies--scale-up from mouse to human using a physiologically-based pharmacokinetic model
5. Physiologically-based pharmacokinetic model for specific and nonspecific monoclonal-antibodies and fragments in normal-tissues and human tumor xenografts in nude-mice
6. Single chain Fv antibodies for targeting cancer therapy
7. Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library
8. Radioimmunoluminography: A tool for relating tissue antigen concentration to clinical outcome
9. Purification of bacterially expressed single-chain Fv antibodies for clinical-applications using metal chelate chromatography
10. Drug-induced perturbations in tumor blood-flow-therapeutic potential and possible limitations
11. A practical method for numerical solution of partial differential equations of the heat conduction type
12. A comparison of image registration techniques for the correlation of radiolabelled antibody distribution with tumour morphology
13. A novel technique, using radioluminography, for the measurement of uniformity of radiolabelled antibody distribution in a colorectal cancer xenograft model
14. A dosimetry model for the accurate characterization of absorbed doses in mouse organs
15. Modelling analysis of the global and microscopic distribution of immunoglobulin-G, F(Ab′)2 and Fab in tumors
16. Accurate quantification of I-131 distribution by gamma-camera imaging
17. Micropharmacology of monoclonal-antibodies in solid tumors-direct experimental-evidence for a binding-site barrier
18. A multicenter phase II study of iodine-131 anti-B1 antibody (Bexxar) in patients (pts) with chemotherapy-relapsed/refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphoma (NHL)
19. Radioimmunotherapy of metastatic colorectal tumors with iodine-131 labelled antibody to carcinoembryonic antigen--phase I/Ii study with comparative biodistribution of intact and F(Ab′)(2) antibodies
20. Enhancement of radioimmunotherapy by drugs modifying tumor blood-flow in a colonic xenograft model
21. Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents
22. A model for dosimetry in radioimmunotherapy
23. Phase-Ii trial of I-131 B1 (Anti-Cd20) antibody therapy with autologous stem-cell transplantation for relapsed B-cell lymphomas
24. Transport of macromolecules across microvascular walls-the 2-pore theory
25. Predicted and observed effects of antibody-affinity and antigen density on monoclonal-antibody uptake in solid tumors
26. Exchange of macromolecules across the microcirculation
27. An analysis of monoclonal-antibody distribution in microscopic tumor nodules-consequences of a binding-site barrier
28. Early intervention in cancer using monoclonal-antibodies and other biological ligands-micropharmacology and the binding-site barrier
29. Mutual stabilization of V-L and V-H in single-chain antibody fragments, investigated with mutants engineered for stability
30. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
31. Pharmacological modification of tumor blood-flow and interstitial fluid pressure in a human tumor xenograft-network analysis and mechanistic interpretation