Intracellular metabolism of triglyceride-rich lipoproteins

Current Opinion in Lipidology

Volumn 12, Issue 3, 2001, Pages 255-260

  Heeren, Joerg ^a   Beisiegel, Ulrike ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN E; LIPOPROTEIN; LIPOPROTEIN LIPASE; LIPOPROTEIN RECEPTOR; LIVER TRIACYLGLYCEROL LIPASE; PROTEOHEPARAN SULFATE; TRIACYLGLYCEROL;

ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; ENDOSOME; HUMAN; INTRACELLULAR TRANSPORT; LIPOPROTEIN METABOLISM; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW;

ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS C; APOLIPOPROTEINS E; CHOLESTEROL; ENDOSOMES; HUMANS; LIPOPROTEINS; MODELS, BIOLOGICAL; PROTEIN BINDING; TRIGLYCERIDES;

EID: 0034983588     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200106000-00003     Document Type: Review

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3. In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL
4. In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity
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8. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
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10. Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment
11. Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages
12. Intracellular processing of endocytosed triglyceride-rich lipoproteins comprises both recycling and degradation
13. Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis
14. Recycling of apolipoprotein E in mouse liver
15. The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro
16. Perlecan heparan sulfate proteoglycan: A novel receptor that mediates a distinct pathway for ligand catabolism
17. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
18. Endocytosis
19. Enrichment of acyl coenzyme A: Cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment
20. Lipid-free apolipoprotein E is internalized via cell surface proteoglycans to the late endosomes but escapes degradation through a non transferrin recycling compartment
21. Endogenously expressed apolipoprotein E has different effects on cell lipid metabolism as compared to exogenous apolipoprotein E carried on triglyceride-rich particles
22. The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components
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26. ABC transporters in cellular lipid trafficking
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34. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis
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36. The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages
37. Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
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39. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations
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43. Phenotypic correction of hypercholesterolemia in apoE-deficient mice by adenovirus-mediated in vivo gene transfer
44. Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice
45. Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice
46. Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice