Selective transduction of murine myelomonocytic leukemia cells (WEHI-3B) with regular and RGD-adenoviral vectors

Molecular Therapy

Volumn 3, Issue 1, 2001, Pages 70-77

  García Castro, Javier ^a   Segovia, José Carlos ^a   García Sánchez, Félix ^b   Lillo, Rosa ^b   Gómez Navarro, Jesús ^c   Curiel, David T ^c   Bueren, Juan A ^a  

^a CIEMAT   (Spain)

^b Centro De Transfusión De La Comunidad De Madrid ^*  (Spain)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; VIRUS RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL POPULATION; CELL SELECTION; CONTROLLED STUDY; DNA MODIFICATION; EXPOSURE; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; INCUBATION TIME; LEUKEMIA CELL; MARKER GENE; MOUSE; MYELOMONOCYTIC LEUKEMIA; NONHUMAN; REPORTER GENE; TIME; TRANSGENE; VIRUS INFECTION; VIRUS INFECTIVITY;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0034980916     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0221     Document Type: Article

References (44)

1. Sensitization of human breast cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene
2. Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer
3. A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma
4. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors
5. Gene transfer into human bone marrow hematopoietic cells mediated by adenovirus vectors
6. Adenovirus vectors for gene transduction into mobilized blood CD34+ cells
7. High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors
8. Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells
9. Adenoviral vector-mediated gene transfer to primitive human hematopoietic progenitor cells: Assessment of transduction and toxicity in long-term culture
10. A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells
11. Selective elimination (purging) of contaminating malignant cells from hematopoietic stem cell autografts using recombinant adenovirus
12. A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow
13. Cytosine deaminase adenoviral vector and 5-fluoro-cytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: A potential purging method for autologous transplantation
14. Ex vivo breast cancer cell purging by adenovirus-mediated cytosine deaminase gene transfer and short-term incubation with 5-fluorocytosine completely prevents tumor growth after transplantation
15. Adenovirus vector infection of chronic lymphocytic leukemia B cells
16. Efficient adenovirus-mediated gene transduction of normal and leukemic hematopoietic cells
17. Efficient adenovirus-mediated gene expression in malignant human plasma cells: Relative lymphoid cell resistance
18. Adenovirus vector-based purging of multiple myeloma cells
19. Transduction of bone marrow cells by the AdZ.F(pK7) modified adenovirus demonstrates preferential gene transfer in myeloma cells
20. Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease
21. Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein
22. Isolation of a common receptor for a coxsackie B viruses and adenoviruses 2 and 5
23. HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
24. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
25. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
26. Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery
27. Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells
28. Interactions of soluble recombinant integrin αvβ5 with human adenoviruses
29. Structure of adenovirus complexed with its internalization receptor, αvβ5 integrin
30. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
31. Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein
32. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
33. Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR
34. Genetic targeting of adenoviral vectors
35. Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector
36. Targeted gene delivery by tropism-modified adenoviral vectors
37. Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with Stem Cell factor and interleukin 11
38. A transplantable myelomonocytic leukemia in BALB/c mice: Cytology, karyotype, and muramidase content
39. Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro
40. Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells
41. Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo
42. Use of protamine to augment adenovirus-mediated cancer gene therapy
43. Purification and characterization of mouse hematopoietic stem cells
44. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts