Adenoviral vector-mediated gene transfer to primitive human hematopoietic progenitor cells: Assessment of transduction and toxicity in long-term culture

Blood

Volumn 96, Issue 1, 2000, Pages 100-108

  MacKenzie, Karen L ^b   Hackett, Neil R ^b   Crystal, Ronald G ^b   Moore, Malcolm A S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GREEN FLUORESCENT PROTEIN; VIRUS VECTOR;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; COLONY FORMING UNIT C; CONTROLLED STUDY; DRUG SAFETY; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034234510     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.1.100     Document Type: Article

References (42)

1. Dunbar CE, Cottler-Fox M, O'Shaughessy JA, et al. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood. 1995;85:3048-3057.
2. Hanania EG, Giles RE, Kavanagh J, et al. Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to post-transplant hematopoietic recovery following intensive systemic therapy. Proc Natl Acad Sci U S A. 1996;94: 15346-15351
3. Larochelle A, Vormoor J, Hanenberg H, et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nature Med. 1996;12:1329-1337.
4. Dao MA, Shah AJ, Crooks GM, Nolta J. Engraftment and retroviral marking of CD34+ and CD34+CD38-human hematopoietic progenitors assessed in immune-deficient mice. Blood. 1998; 91:1243-1255.
5. Hessdorfer C, Ayello J, Ward M, et al. Phase I trial of retroviral mediated gene transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem cell transplantation. J Clin Oncol. 1998;16:165-172.
6. Hao Q-L, Shah AJ, Thiemann FT, Smogorzewska EM, Crooks GM. A functional comparison of CD34+ CD38-cells in cord blood and bone marrow. Blood, 1995;86:3745-3753.
7. lo human marrow cells after in vitro cytokine exposure. Blood. 1995;85:1480-1487.
8. Miller DG, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol. 1990;10:4239-4242.
9. Lewis PF, Emmerman M. Passage through mitosis is required for oncoretroviruses but not the human immunodeficiency virus. J Virol. 1994;68: 510-516.
10. Nolta JA, Smogortzewska EM, Kohn DB. Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells. Blood. 1995;86:101-110.
11. Jo D-Y, Raafi S, Hamada T, Moore MAS. Transendothelial chemotaxis and marrow homing of hematopoietic stem cells are mediated by stromal derived factor-1 (SDF-1) signalling through the chemokine receptor CXCR-4. J Clin Invest. 2000;105:101-111.
12. Orlic D, Girard LJ, Jordan C, Anderson SM, Cline AP, Bodine DM. The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction. Proc Natl Acad Sci U S A. 1996;93:11097-11102.
13. Bergelson JM, Cunningham JA, Droguett G, et al. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science. 1997;275:1320-1323.
14. Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997;94:3352-3356.
15. Frey B, Hackett NR, Bergelson JM, et al. High-efficiency gene transfer into ex vivo expanded human hematopoietic progenitors and precursor cells by adenovirus vectors. Blood. 1998;91: 2781-2792.
16. Huang S, Kamata T, Takada Y, Ruggier ZM, Nemerow GR. Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoieitc cells. J Virol. 1996;70:4502-4506.
17. Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins ανβ3 and ανβ5 promote adenovirus internalization but not virus attachment. Cell. 1993;73:309-319.
18. Croyle MA, Walter E, Janich S, Roessler BJ, Amidon GL. Role of integrin expression in adenovirus-mediated gene delivery to the intestinal epithelium. Hum Gene Ther. 1998;9:561-573.
19. Lievesveld JL, Winslow JM, Frediani KE, Ryan DH, Abboud CN. Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells. Blood. 1993; 81:112-121.
20. Kerst MJ, Sanders JB, Ineke CM, et al. α4β1 and α5β1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way. Blood. 1993;81:344-351.
21. Neering SJ, Hardy SF, Minamoto D, Spratt SK, Jordan CT. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors. Blood. 1996;88:1147-1155.
22. Watanabe T, Kuszynski C, Ino K, et al. Gene transfer into human bone marrow hematopoietic cells mediated by adenovirus vectors. Blood. 1996;87:5032-5039.
23. Weber M, Deng S, Kucher T, Shaked A. Ketchum RJ, Brayman KL. Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function. J Surg Res. 1997;69:23-32.
24. Teramato S, Johnson LG, Huang W, Leigh MW, Boucher RC. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells Hum Gene Ther. 1995;6: 1045-1053.
25. + adenoviral gene transfer vectors function as "pro-life" signal to promote survival of primary human endothelial cells. Blood. 1999;93:2936-2944.
26. Shtrichman R, Kleinberger T. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J Virol. 1998;72:2975-2982.
27. Gao G-P, Yang Y, Wilson JM. Biology of adenovirus with E1 and E4 deletions for liver directed gene therapy. J Virol. 1996;70:8934-8943.
28. Song W, Kong H-L, Traktman P, Crystal RG. Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum Gene Ther. 1997;8:1207-1217.
29. Itoh K, Tezuka H, Sakoda H, et al. Reproducible establishment of hematopoietic supportive cell lines from murine bone marrow. Exp Hematol. 1989;17:145-153.
30. Petzer AL, Hogge DE, Landsdorp PM, Reid DS, Eaves CJ. Self renewal of primitive human hematopoietic cells (long term culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci U S A. 1996;93:1470-1474.
31. Huang S, Terstappen LMM. Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38-hematopoietic stem cells. Blood. 1994;83:1515-1526.
32. Conneally E, Eaves CJ, Humphries RK. Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential. Blood. 1998; 91:3487-3493.
33. Moore MAS, Hoskins I. Ex vivo expansion of cord blood-derived stem cells and progenitors. Blood Cells. 1994;20:468-479.
34. Keller JR, Mariaestela O, Ruscetti FW. Steel factor (c-kit ligand) promotes the survival of hematopoieitc stem/progenitor cells in the absence of cell division. Blood. 1995;86:1757-1764.
35. Borge OJ, Ramsfjell V, Cui L, Jacobsen SEW. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38-bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin. Blood. 1997;90:2282-2292.
36. Bregni M, Shammah S. Malaffo F, et al, Adenovirus vectors for gene transduction into mobilized blood CD34+ cells. Gene Ther. 1998:5:465-472.
37. Fu SQ, Sanchez FG, Chung I, Deisseroth A. Adenoviral vectors and hematopoietic cells [letter]. Blood. 1997;89:1460-1462.
38. Clarke MF, Apel IJ, Benedict MA, et al, A recombinant bcl-xs adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc. Natl Acad Sci U S A. 1995;92: 11024-11028.
39. Seth P, Brinkman U, Schwartz GN, et al, Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging. Cancer Res. 1996;56: 1346-1351.
40. Teoh G, Chen L, Urashima M, et al. Adenovirus vector-based purging of multiple myeloma cells. Blood. 1998;12:4591-4601.
41. Hanenberg, H, Hashino K, Konishi H, Hock RA, Kato I, Williams DA. Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. Hum Gene Ther. 1997;8:2193-2206.
42. Scott-Taylor TH, Gallardo HF, Gansbacher B, Sadelain M. Adenovirus facilitated infection of human cells with ecotropic retrovirus. Gene Ther. 1998;5:621-629.