A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow

Human Gene Therapy

Volumn 8, Issue 2, 1997, Pages 157-170

  Kim, Myunghee ^a   Wright, Marci ^a   Deshane, Jessy ^a   Accavitti, Mary Ann ^a   Tilden, Arabella ^a,b   Saleh, Mansoor ^b   Vaughan, William P ^a,b   Carabasi, Matthew H ^a,b   Rogers, Miriam D ^c   Hockett Jr , Richard D ^c   Grizzle, William E ^c   Curiel, David T ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ONCOPROTEIN;

ADENOVIRUS; ARTICLE; BONE MARROW; BONE MARROW CELL; BONE MARROW PURGING; CANCER CELL; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; EXPRESSION VECTOR; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; ONCOGENE NEU; PROSTATE CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 16944364446     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.2-157     Document Type: Article

References (38)

1. BOCIEK, R.G., STEWART, D.A., and ARMITAGE, J.O. (1995). Bone marrow transplantation - current concepts. J. Invest. Med. 43, 127-135.
2. BRODY, S.L., JAFFE, H.A., HAN, S.K., WERSTO, R.P., and CRYSTAL, R.G. (1994). Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors. Hum. Gene Ther. 5, 437-447.
3. CHU, Y., SPERBER, K., MAYER, L., and HUS, M-T. (1992). Persistent infection of human adenovirus type 5 in human monocyte cell lines. Virology 188, 793-800.
4. s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc. Natl. Acad. Sci. USA 92, 11024-11028.
5. COLAK, A., GOODMAN, J.C., CHEN, S-H, WOO, S., GROSSMAN, R.G., and SHINE, H.D. (1995). Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain. Hum. Gene Ther. 6, 1317-1322.
6. CURIEL, D.T., WAGNER, E., COTTEN, M., BIRNSTEIL, M.L., AGARWAL, S., LI, C-M, LOECHEL, S., and HU, P-C. (1992). High efficiency in vitro gene transfer mediated by an adenovirus coupled to DNA-polylysine complexes. Hum. Gene Ther. 3, 147-154.
7. CURIEL, T.J., COOK, D.R., BOGEDAIN, C., JILG, W., HARRISON, G.S., COTTEN, D.T., CURIEL, D.T., and WAGNER, E. (1994). Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells. Virology 198, 577-585.
8. DESHANE, J., LOECHEL, F., CONRY, R.M., SIEGAL, G.P., KING, C.R., and CURIEL, D.T. (1994). Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cell lines. Gene Ther. 1, 332-337.
9. DESHANE, J., CABRERA, G., GRIM, J.E., SIEGAL, G.P., PIKE, J., ALVAREZ, R.D., and CURIEL, D.T. (1995a). Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody. Gynecolog. Oncol. 59, 8-14.
10. DESHANE, J., SIEGAL, G.P., ALVAREZ, R.D., WANG, M., FENG, M., CABRERA, G., LIU, T., KAY, M., and CURIEL, D.T. (1995b). Targeted tumor killing via an intracellular antibody against erbB-2. J. Clin. Invest. 96, 2980-2989.
11. DESHANE, J., GRIM, J., LOECHEL, S., SIEGAL, G.P., ALVAREZ, R.D., KING, C.R., and CURIEL, D.T. (1996). Intracellular antibody directed against erbB-2 mediates tumor cell eradication by inducing apoptosis. Cancer Gene Ther. 3, 89-98.
12. DI FIORE, P.P., SEGATTO, O., TAYLOR, W.G., AARONSON, S.A., and PIERCE, J.H. (1990). EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science 248, 79-82.
13. EVINGER-HODGES, M.J., BLICK, M., BRESSER, J., and DICKE, K.A. (1987). Comparison of oncogene expression in human normal bone marrow and leukemia. Ann. N.Y. Acad. Sci. 511, 284-291.
14. FAUCON, N., OGIER, G., and CHARDONNET, Y. (1982). Changes in human adenovirus 5 propagated in Burkitt's Lymphoma cells. J. Natl. Cancer Inst. 69, 1215-1220.
15. FENG, M., CABRERA, G., DESHANE, J., SCANLON, K.J., and CURIEL, D.T. (1995). Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme. Cancer Res 55, 2024-2028.
16. GEE, A. (1995). Purging of peripheral blood stem cell grafts. Stem Cells 13(Suppl. 3), 52-62.
17. GRIBBEN, J.G., and NADLER, L.M. (1993). Bone marrow purging for autologous bone marrow transplantation. Leuk. Lymphoma 11(Suppl. 2), 141-148.
18. GRIM, J., DESHANE, J., FENG, M., LIEBER, A., KAY, M., and CURIEL, D.T. (1996). ErbB-2 knockout employing an intracellular single chain antibody (sFv) accomplishes specific toxicity in erbB-2 expressing lung cancer cells. Am. J. Respir. Cell. Mol. Biol. 15, 348-354.
19. 7. Proc. Natl. Acad. Sci. USA 92, 537-541.
20. HADDADA, H., LOPEZ, M., MARTINACHE, C., RAGOT, T., ABINA, M.A., and PERRICAUDET, M. (1993). Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages. Biochem. Biophys. Res. Commun. 195, 1174-1183.
21. HOCKETT, JR., R.D., JANOWSKI, K.M., and BUCY, R.P. (1995). Simultaneous quantitation of multiple cytokine mRNAs by RT-PCR utilizing plate based EIA methodology. Immunol. Methods 187, 273-285.
22. HORVATH, J., and WEBER, J.M. (1988). Nonpermissivity of human peripheral blood lymphocytes to adenovirus type 2 infection. J. Virol. 62, 341-345.
23. HUANG, S., ENDO, R.I., and NEMEROW, G.R. (1995). Upregulation of integrins avb3 and avb5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery J. Virol. 69, 2257-2263.
24. JUNEJA, H.S., HARVEY, W.H., BRASHER, W.K., and THOMPSON, E.B. (1995). Successful in vitro purging of leukemic blasts from marrow by cortavizol, a pyrazolosteroid: A preclinical study for autologous transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma. Leukemia 9, 1771-1778.
25. KIES, M.S., GORDON, L.I., ROSEN, S.T., KUCUK, O., and VRIESENDORP, H.M. (1988). Autologous bone marrow transplantation in breast cancer: separation of clonogenic tumor cell colonies by gradient fractionation. Exp. Hematol. 16, 190-194.
26. KIM, M., ACAVITTI, M.A., SALEH, M.N., ROSENFELD, M.E., JOHANNING, F.-W., CURIEL, T.J., and CURIEL, D.T. (1996). Adenoviral vector mediated delivery of the herpes simplex virus thymidine kinase gene sensitizes EBV-transformed B cell lines to ganciclovir. Tumor Targeting (in press).
27. MEYER, B.F., STONER, M.L., RAPHAEL, C.L., DAVIS, R.E., and HERMANN, R.P. (1991). Strepavidin-biotin immunotoxins: a new approach to purging bone marrow. Exp. Hematol. 19, 710-713.
28. MITANI, K., GRAHAM, F.L., and CASKEY, C.T. (1994). Transduction of human bone marrow by adenoviral vector. Hum. Gene Ther. 5, 941-948.
29. MORIYAMA, Y., GOTO, T., HASHIMOTO, S., T. FURUKAWA, T., KISHI, K., TAKAHASHI, M., and SHIBATA, A. (1992). A simple elimination of clonogenic tumor cells from human bone marrow in vitro by heat: Its application to autologous bone marrow transplantation for B-cell lymphoma. Ann. Hematol. 64, 256-269.
30. MYKLEBUST, A.T., GODAL, A., JUELL, S., PHARO, A., and FODSTAD, Ø. (1994). Comparison of two antibody-based methods for elimination of breast cancer cells from human bone marrow. Cancer Res. 54, 209-214.
31. O'BRIANT, K.C., SHPALL, E.J., HOUSTON, L.L., PETERS, W.P., and BAST, R.C. (1991). Elimination of clonogenic breast cancer cells from human bone marrow: A comparison of immunotoxin treatment with chemoimmunoseparation using 4-hydroperoxy-cyclophosphamide, monoclonal antibodies, and magnetic microspheres. Cancer 68, 1272-1278.
32. PETERS, W.B., ROSS, M., VREDENBURGH, J.J., MEISENBERG, B., MARKS, L.B., WINER, E., KURTZBERG, J., BAST, R.C., JONES, JR., R. SHPALL, E., WU, K., ROSNER, G., GILBERT, C., MATTHIAS, B., CONIGLIO, D., PETROS, W., HENDERSON, I.C., NORTON, L., WEISS, R.B., BUDMAN, D., and HURD, D. (1993). High-dose chemotherapy and autologous bone marrow support as consolidation after standard-dose adjuvant therapy for high-risk primary breast cancer. J. Clin. Oncol. 11, 1132-1143.
33. ROSENFELD, M.R., FENG, M., MICHAEL, S.I., SIEGAL, G.P., ALVAREZ, R.D., and CURIEL, D.T. (1995). Adenoviral mediated delivery of the HSV thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir. Clin. Cancer Res. 1, 1571-1580.
34. SILVER, L., and ANDERSON, C.W. (1988). Interaction of human adenovirus serotype 2 with human lymphoid cells. Virology 165, 377-387.
35. SIMPSON, S.J., VACHULA, M., KENNEDY, M.J., KAIZER, H., COON, J.S., GHALIE, R., WILLIAMS, S., and VAN EPPS, D. (1995). Detection of tumor cells in the bone marrow, peripheral blood, and apheresis products of breast cancer patients using flow cytometry. Exp. Hematol. 23, 1062-1068.
36. STOCKSCHLADER, M., HEGEWISCH-BECKER, S., KRUGER, W., TOM DIECK, A., MROSS, K., HOFFKNECHT, M., BERGER, C., KOHLSCHÜTTER, B., MARTIN, H., PETERS, S., KABISCH, H., KUSE, R., WEH, H., and ZANDER, A. (1995). Bone marrow transplantation for Philadelphia-chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant. 16, 663-667.
37. WARWRZYNCZAK, E.J. (1992). Rational design of immunotoxins: Current progress and future prospects. Anti-Cancer Drug Design 7, 427-441.
38. WOOD, D.P., JR., BANKS, E.R., HUMPHREYS, S., MCROBERTS, J.W., and RANGNEKAR, V.M. (1994). Identification of bone marrow micrometastases in patients with prostate cancer. Cancer 74, 2533-2540.