A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects

Neuropsychopharmacology

Volumn 25, Issue 2, 2001, Pages 213-223

  Verhoeff, N P L G ^a,b   Kapur, S ^a   Hussey, D ^a   Lee, M ^a   Christensen, B ^a   Papatheodorou, G ^a   Zipursky, R B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Methyl para tyrosine; 11C raclopride; Dopamine; Dopamine D2 receptors; In vivo binding; Positron emission tomography

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; DOPAMINE; DOPAMINE 2 RECEPTOR; HOMOVANILLIC ACID; METIROSINE; NORADRENALIN; PROLACTIN; RACLOPRIDE; TRACER;

ADULT; ARTICLE; ATTENTION; BINDING AFFINITY; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE DEPLETION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HAPPINESS; HUMAN; IN VIVO STUDY; MALE; METABOLITE; NEOSTRIATUM; NORMAL HUMAN; PERFORMANCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; RECEPTOR BINDING; RECEPTOR OCCUPANCY; SYNAPSE;

ADULT; ALPHA-METHYLTYROSINE; ANALYSIS OF VARIANCE; COGNITION; DOPAMINE; DOPAMINE ANTAGONISTS; ENZYME INHIBITORS; FEMALE; HOMOVANILLIC ACID; HUMANS; MALE; METHOXYHYDROXYPHENYLGLYCOL; NEOSTRIATUM; OUTCOME ASSESSMENT (HEALTH CARE); PROLACTIN; RACLOPRIDE; RECEPTORS, DOPAMINE D2; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034979446     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(01)00231-7     Document Type: Article

References (55)

1. Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort
2. 2 receptors by dopamine in schizophrenia
3. Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder
4. Short form of depression inventory cross-validation
5. Assessment of endogenous dopamine release by methylphenydate challenge using iodine-123 iodobenzamide single-photon emission tomography
6. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
7. Requirements and implementation of a flexible kinetic modeling tool
8. 2 sites
9. Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: Study with intravenous midazolam
10. The extrapyramidal symptom rating scale
11. 123I in humans
12. Metabolism of alpha-methyltyrosine in man: Relationship to its potency as an inhibitor of catecholamine biosynthesis
13. In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology
14. Statistical parametric maps in functional imaging: A general linear approach
15. 2 receptor occupancy by endogenous dopamine in healthy humans
16. 2-dopamine receptors in the monkey brain
17. Parametric imaging of ligand-receptor binding in PET using a simplified reference tissue model
18. 11C]raclopride binding in rat striatum, quantified using PET
19. 11C]raclopride binding
20. 2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5
21. Upregulation of postsynaptic dopamine receptors in the striatum does not influence haloperidol-induced catalepsy in mice
22. 2-like receptors: An immunocytochemical study of subtype-specific antibodies in rat and human brain
23. Simplified reference tissue model for PET receptor studies
24. 11C]raclopride studies
25. Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review
26. 2 receptor occupancy by endogenous dopamine in humans
27. Four isoforms of tyrosine hydroxylase are expressed in human brain
28. 125I]iodosulpride, a highly selective ligand
29. Sleep deprivation and impaired cognition. Possible role of brain catecholamines
30. Effects of catecholamine depletion on alertness and mood in rested and sleep deprived normal volunteers
31. Assessment of spatial normalization of PET ligand images using ligand-specific templates
32. Study of dopamine turnover by monitoring the decline of dopamine metabolites in rat CSF after alpha-methyl-p-tyrosine
33. 2 receptor radioligands in rat striatum
34. 2 receptor binding and mRNA after 6-OHDA lesions of the medial forebrain bundle in the rat brain
35. 2 dopamine receptor autoradiography: High percentage of high-affinity agonist sites and increased nucleotide sensitivity in tissue sections
36. 3H-raclopride in the mouse brain in vivo
37. Gas chromatographic quantitation of methoxyamphetamine and three of its metabolites in plasma
38. Human prolactin: 24-Hour pattern with increased release during sleep
39. Dopamine and the mechanisms of cognition. II. D-amphetamine effects in human subjects performing a selective attention task
40. 2 dopamine receptor
41. A gas chromatographic-mass spectrometric (GC-MS) assay for 3-methoxy-4-hydroxyphenylethyleneglycol and vanylmandelic acid in human serum
42. Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
43. 11C]raclopride in the human brain
44. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
45. Comparison of two PET radioligands for imaging extrastriatal dopamine receptors in the human brain
46. 2 receptors
47. 2 receptors in thalamus and in temporal insula of human subjects
48. Quantitation of catecholamine metabolites by gas chromatography-mass spectrometry with selected ion monitoring
49. 11C-diprenorphine binding in Huntington's disease: A comparison of region of interest analysis with statistical parametric mapping
50. The impact of gender on alpha-methyl-para-tyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion