Age associated decrements in dopamine D2 receptors in thalamus and in temporal insula of human subjects

Life Sciences

Volumn 59, Issue 1, 1996, Pages

  Wang, Gene Jack ^a,b   Volkow, Nora D ^a,b   Fowler, Joanna S ^a   Logan, Jean ^a   Gur, Ruben ^c   Netusil, Noelwah ^a   Hitzemann, Robert J ^b   Pappas, Naomi S ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

aging; extrastriatal dopamine receptors; positron emission tomography; 11C raclopride

Indexed keywords

DOPAMINE 2 RECEPTOR;

ADULT; AGED; AGING; ARTICLE; HUMAN; HUMAN EXPERIMENT; INSULA; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; TEMPORAL CORTEX; THALAMUS; TISSUE DISTRIBUTION; VOLUNTEER;

EID: 0343371815     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(96)00262-7     Document Type: Article

References (23)

1. P. SEEMAN, N.H. BZOWE, H.G. GUAN, C. BERGERON, L.E. BECKER, G.P. REYNOLDS, E.D. BIRD, P. RIEDER, K.J. JELLINGER, S. WATANABE and W. TOURTELLOTTE, Synape, 1 399-404 (1987).
2. J.O. RINNE, P. LONNBERG and P. MARJAMAKI, Brain Res, 508 349-352 (1990).
3. D.F. WONG, H.N. WAGNER JR, R.F. DANNALS, J.M. LINKS, J.J. FROST, H.T. RAVERT, A. WILSON, A. ROSENBAUM, A. GJEDDE, K.H. DOUGLASS, M FOLSTEIN, J.T. TOUNG, H.D. BURNS and M.J. KUHAR, Science, 226 1393-1396 (1984).
4. A. ANTONINI, K.L. LEENDERS, H. REIST, R. THOMANN, H-F BEER and J. LOCHER, Arch Neurology, 50 474-480 (1993).
5. J.C. BARON, B. MAZIERE, C. LOCH, H. CAMBON, P. SGOURROPOULOS, A.M. BONNET and Y. AGID, J Cereb Blood Flow Metab, 6 131-136 (1986).
6. J.O. RINNE, J. HIETALA, U. RUOTSALAINEN, E. SAEKOE, A. LAIHINEN, K. NAGREN, P. LEHIKOINEN, V. OIKONE and E. SYVALAHTI, J Cereb Blood Flow Metab 13 310-314 (1993).
7. G.-J. WANG, N.D. VOLKOW, J.S. FOWLER, A.P. WOLF, R.R. MACGREGOR, D.J. SCHLYER and R.J. HITZEMANN, Synapse, 15 246-249 (1993).
8. K.A. YOUSEF, N.D. VOLKOW, D.J. SCHLYER, J.S. FOWLER A.P.WOLF, G.-J. WANG, M.R. SMITH, J.D. BRODIE and D. WARNER, Synapse, 19 14-17 (1995)
9. L. FARDE, C., HALLDIN, T. SUHARA, S. NYBERG, P. KARLSSON, T. HOGBERG, H. HALL and C.-G. SWAHN, J Nucl Med, 35 84P (1994)
10. R.M. KESSLER, N.S. MASON, J.R. VOTAW, T. DE PAULIS, J.A. CLANTON, M.S., ANSARI, D.E. SCHMIDT, R.G. MANNING and R.L. BELL, Eur J Pharmacol, 223 105-107 (1992).
11. M. CAMPS, R. CORTES, B. GUEYE, A. PROBST and J.M. PALACIOS, Neuroscience 28 275-290 (1989).
12. R.M. KESSLER, W.O. WHETSELL, M.S. ANSARI, J.R. VOTAW, T. DE PAULIS, J.A. CLANTON, D.E. SCHMIDT, N.S. MASON and R.G. MANNING, Brain Res 609 237-243 (1993).
13. N.D. VOLKOW, G.-J. WANG, J.S. FOWLER, J. LOGAN, J.S. GATLEY, R.R. MACGREGOR, D. SCHLYER, R. HITZEMANN and A.P. WOLF, Psychiatry Res. (in press).
14. N.D. VOLKOW, J.S. FOWLER, G.-J. WANG, S.L. DEWEY, D.J. SCHLYER, R. MACGREGOR, J. LOGAN, D. ALEXOFF, C. SHEA, R.J. HITZEMANN, B. ANGRIST and A.P. WOLF, J Nucl Med 34 609-613 (1993).
15. J. LOGAN, J.S. FOWLER, N.D. VOLKOW, A.P. WOLF, S.L. DEWEY, D.J. SCHLYER, R. MACGREGOR, R.J., HITZEMANN, B. BENDRIEM, S.J. GATLEY and D.R. CHRISTMAN, J Cereb Blood Flow Metab, 10 740-747 (1990).
16. D.G. MORGAN, J.O. MARCUSSON, P. NYBERG, P. WESTER, B. WINBLAD, M.N. GORDON and C.E. FINCH, Neurobiol Aging 8 195-201 (1987).
17. H.J. GROENEWEGEN, Neuroscience, 24 379-431 (1988).
18. C. VOGT and O. VOGT J Psychol und Neurol 50 32-154 (1941).
19. J.H. XUEREB, R.H. PERRY, J.M. CANDY, E.K. PERRY, E. MARSHALL and J.R. BONHAM. Brain 114 1363-1379 (1991).
20. M.B. CARPENTER and J. SUTIN. Human Neuroanatomy. Eighth edition. Baltimore: Williams and Wilkins (1983).
21. A.F. OKE and R.N. ADAMS, Schizophrenia Bull, 13 589-604 (1987).
22. J.L. CUMMINGS, Arch Neurol 50 873-880 (1993).
23. G.S. ROTH and J.A. JOSEPH, Gerontology, 34 22-28 (1988).