Mitochondrial DNA deletions parallel age-linked decline in rat sensory nerve function

Neurobiology of Aging

Volumn 22, Issue 4, 2001, Pages 635-643

  Nagley, Phillip ^a   Zhang, Chunfang ^a   Lim, Maria L R ^a   Merhi, Merhi ^b   Needham, B Elise ^a   Khalil, Zeinab ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Animal model; Capsaicin; Dorsal root ganglia; Mitochondrial DNA; Multiple deletions; Polymerase chain reaction; Rat; Sciatic nerve; Substance P; Vascular response

Indexed keywords

CAPSAICIN; MITOCHONDRIAL DNA; SUBSTANCE P;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; HINDLIMB; MALE; MUTATION; NERVE FUNCTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SCIATIC NERVE; SENESCENCE; SENSORY NERVE; SPINAL GANGLION;

AGING; ANIMALS; CAPSAICIN; DNA, MITOCHONDRIAL; ELECTRIC STIMULATION; GANGLIA, SPINAL; GENE DELETION; HINDLIMB; MALE; NEURONS, AFFERENT; NITROPRUSSIDE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SCIATIC NERVE; SUBSTANCE P; VASODILATOR AGENTS;

EID: 0034977566     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00228-7     Document Type: Article

References (53)

1. A rat model to assess the effect of ageing and the primary afferent nervous system on wound healing
2. Chromatographic evidence for the presence of multiple tachykinins in the bovine adrenal medulla
3. Multiple deletions in mitochondrial DNA are present in senescent mouse brain
4. Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P
5. Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
6. Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA
7. Mitochondrial electron transport chain activities and DNA deletions in regions of the rat brain
8. Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs
9. Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats
10. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
11. Age-related extensive fragmentation of mitochondrial DNA into minicircles
12. Neurogenic flare responses following topical application of capsaicin in humans
13. Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
14. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons
15. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
16. Sequence of events in substance P-mediated plasma extravasation in rat skin
17. Serotonin modulates substance P-induced plasma extravasation and vasodilatation in rat skin by an action through capsaicin-sensitive primary afferent nerves
18. Sensory peptides as neuromodulators of wound healing in aged rats
19. Sympathetic modulation of sensory nerve activity with age: Human and rodent skin models
20. Effects of ageing on sensory nerve function in rat skin
21. Decreased survival of experimental critical skin flaps in rats after sensory denervation with capsaicin
22. Deltoid human muscle mtDNA is extensively rearranged in old age subjects
23. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
24. Mitochondrial DNA - All things bad?
25. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
26. Mitochondrial DNA mutation and the ageing process: Bioenergy and pharmacological intervention
27. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing
28. The development of mitochondrial medicine
29. Involvement of a peripheral site of action in the early phase of neuropeptide depletion following capsaicin desensitization
30. Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age
31. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle
32. CGRP and nitric oxide of neuronal origin and their involvement in neurogenic vasodilatation in rat skin microvasculature
33. Age-related changes in sympathetic modulation of sensory nerve activity in rat skin
34. Ageing and mitochondrial genetics
35. Mitochondrial DNA mutations in aging
36. Neurotransmitter functions of mammalian tachykinins
37. Genetic and functional changes in mitochondria associated with aging
38. Mitochondria oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications
39. Impaired neurogenic vascular response in patients with diabetes and neuropathic foot lesions
40. Nitric oxide and sensory nerves are involved in the vasodilator response to acetylcholine but not calcitonin gene-related peptide in rat skin microvasculature
41. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
42. Multiple deletions are detectable in mitochondrial DNA of aging mice
43. Multiple, large deletions in rat mitochondrial DNA: Evidence for a major hot spot
44. Mitochondrial genetics: A paradigm for aging and degenerative diseases?
45. Mitochondrial DNA sequence variation in human evolution and disease
46. Oxidative stress and mitochondrial DNA mutations in human aging
47. Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve
48. Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans
49. Multiple mitochondrial DNA deletions in an elderly human individual
50. Varied prevalence of age-associated mitochondrial DNA deletions in different species and tissues: A comparison between human and rat
51. Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging
52. Gross mosaic pattern of mitochondrial DNA deletions in skeletal muscle tissues of an individual adult human subject