Increasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain

Protein Science

Volumn 10, Issue 7, 2001, Pages 1454-1465

  Jiang, Xin ^a   Kowalski, Jennifer ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Homology based; Protein design; Protein stability; Sequence alignment; Side chain interactions; Structure comparison; WW domain

Indexed keywords

HYDROGEN; LIGAND; PROTEIN;

ARTICLE; ELECTRICITY; GENETIC PROCEDURES; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TEMPERATURE DEPENDENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CARRIER PROTEINS; DRUG DESIGN; DRUG STABILITY; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEINS; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SPECTRUM ANALYSIS;

EID: 0034976980     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.640101     Document Type: Article

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