Success and failure of triptans

Journal of Headache and Pain

Volumn 2, Issue 1, 2001, Pages 3-11

  Saxena, Pramod R ^a   Tfelt Hansen, Peer ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

5 HT receptors; Coronary artery constriction; Migraine; Migraine therapy; Sumatriptan; Triptans

Indexed keywords

ALMOTRIPTAN; ANTIMIGRAINE AGENT; DONITRIPTAN; ELETRIPTAN; FROVATRIPTAN; NARATRIPTAN; RIZATRIPTAN; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 1F RECEPTOR; SEROTONIN AGONIST; SUMATRIPTAN; UNCLASSIFIED DRUG; ZOLMITRIPTAN;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTERIOVENOUS FISTULA; ARTERY CONSTRICTION; BLOOD VESSEL; BRAIN ARTERY; CAROTID ARTERY FLOW; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; GUINEA PIG; HEADACHE; HUMAN; INHIBITION KINETICS; ISOLATION PROCEDURE; KIDNEY CLEARANCE; LIPOPHILICITY; MEDICAL RESEARCH; MIGRAINE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PATIENT CARE; PHYSICIAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECURRENT DISEASE; REVIEW; THORAX DISEASE; TREATMENT FAILURE; TRIGEMINAL NERVE; VASOCONSTRICTION;

EID: 0034973113     PISSN: 11292369     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101940170040     Document Type: Review

References (31)

1. 1-like receptors: A time to bid goodbye
2. Pharmacology of triptans
3. Mode of action of the anti-migraine drug sumatriptan
4. Sumatriptan. An updated review of its use in migraine
5. 1B/1D receptor agonists in the acute treatment of migraine
6. Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
7. Migraine pain associated with middle cerebral artery dilatation: Reversal by sumatriptan
8. Antimigraine drug sumatriptan increases blood flow velocity in large cerebral arteries during migraine attacks
9. 1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors
10. 1B receptor antagonist with negative intrinsic activity
11. 1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5- methyl-1,2,4-oxadiazol-3-yl)biphenyl-4- yl]carbonyl]-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] ]autoreceptor function both in vitro and in vivo
12. 1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses
13. 1D receptor
14. 1F receptor antagonists in human and bovine cerebral arteries: Similarity with human coronary artery
15. 2α
16. Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels
17. 1 antagonist CP-99,994 on plasma extravasation in dura mater and c-fos mRNA expression in trigeminal nucleus caudalis of rats
18. P/Q-type Ca2+ channel defects in migraine, ataxia and epilepsy
19. Pharmacological aspects of experimental headache models in relation to acute antimigraine therapy
20. Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine
21. Neurogenic inflammation in the pathophysiology and treatment of migraine
22. Current concepts of the pathophysiology of migraine
23. Neural processing of craniovascular pain: A synthesis of the central structures involved in migraine
24. Novel compounds in development for treatment of acute migraine
25. Pathophysiology of migraine - New insights
26. Blockade of calcitonin gene-related peptide release after superior sagittal sinus stimulation in cat: A comparison of avitriptan and CP122,288
27. Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
28. Neurogenic vasodilation in rabbit basilar isolated artery: Involvement of calcitonin-gene related peptide
29. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
30. Coronary side-effect potential of current and prospective antimigraine drugs
31. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels