Functional characterization of interferon regulatory factor 3a (IRF-3a), an alternative splice isoform of IRF-3

Molecular and Cellular Biology

Volumn 21, Issue 13, 2001, Pages 4169-4176

  Karpova, A Y ^a   Ronco, L V ^a   Howley, P M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 3A; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVITY; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA SPLICING; TRANSCRIPTION INITIATION; VIRUS INFECTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; DIMERIZATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; REGULATORY SEQUENCES, NUCLEIC ACID; RESPIROVIRUS; TRANSCRIPTION FACTORS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0034972164     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.13.4169-4176.2001     Document Type: Article

References (31)

1. Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
2. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3
3. NF-kappa B: Ten years after
4. Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha
5. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
6. Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-jun heterodimer orientation
7. Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
8. Multiple mechanisms of transcriptional repression by YY1
9. Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation
10. The role of interferon regulatory factors in the interferon system and cell growth control
11. Complementation of the radiosensitive MO59J cell line
12. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3
13. Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene
14. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
15. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
16. Structural and functional analysis of interferon regulatory factor 3: Localization of the transactivation and autoinhibitory domains
17. Cloning and functional analysis of the human IRF-3 promoter
18. Interferon regulatory factors: The next generation
19. Structure and function of the interferon-beta enhanceosome
20. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain
21. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons
22. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription
23. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex
24. The growing family of interferon regulatory factors
25. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
26. Interferons and other cytokines
27. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo
28. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
29. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
30. IRF-7, a new interferon regulatory factor associated with Epstein-BarR virus latency
31. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs