Pravastatin therapy increases procollagen I N-terminal propeptide (PINP), a marker of bone formation in post-menopausal women

Clinica Chimica Acta

Volumn 308, Issue 1-2, 2001, Pages 133-137

  Mostaza, Jose M ^a   De La Piedra, Concepción ^b   Díaz Curiel, Manuel ^b   Peña, Rocío ^a   Lahoz, Carlos ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Bone formation; HMG CoA reductase inhibitors; Pravastatin; Procollagen I aminoterminal propeptide; Procollagen III aminoterminal propeptide

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; BIOCHEMICAL MARKER; CHOLESTEROL; COLLAGEN TYPE 1; PEPTIDE DERIVATIVE; PRAVASTATIN; PROCOLLAGEN; PROCOLLAGEN TYPE 1; PROCOLLAGEN TYPE 3; PROPEPTIDE; TELOPEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BONE TURNOVER; CARBOXY TERMINAL SEQUENCE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG SCREENING; FEMALE; FIBROGENESIS; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; LIPID DIET; LIVER; MULTICENTER STUDY; OSSIFICATION; OSTEOLYSIS; POPULATION RESEARCH; POSTMENOPAUSE; PRIORITY JOURNAL;

ADULT; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; BONE REGENERATION; CHOLESTEROL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MIDDLE AGED; PEPTIDE FRAGMENTS; POSTMENOPAUSE; PRAVASTATIN; PROCOLLAGEN;

EID: 0034970424     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(01)00476-4     Document Type: Article

References (15)

1. Stimulation of bone formation in vitro and in rodents by statins
2. Sequential effects of chronic human PTH (1-84) treatment of estrogen-deficiency osteopenia in the rat
3. A variation in bone alkaline phosphatase levels that correlates positively with bone loss and normal levels of aminoterminal propeptide of collagen I in girls with anorexia nervosa
4. The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis
5. Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
6. The aminoterminal propeptide of type I procollagen: Evaluation of a commercial radioimmunoassay kit and values in healthy subjects
7. The assessment of bone metabolism in vivo using biochemical approaches
8. Biochemical markers of bone formation in the study of postmenopausal osteoporosis
9. Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis
10. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
11. HMG-CoA reductase inhibitors and the risk of fractures
12. Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women
13. Oral statins and increased bone-mineral density in postmenopausal women
14. HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients
15. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells