IL-12 enhances lymphoaccumulation by suppressing cell death of T cells in MRL-lpr/lpr mice

Journal of Autoimmunity

Volumn 16, Issue 2, 2001, Pages 87-95

  Xu, Heping ^a,b   Kurihara, Hitoshi ^a   Ito, Tomomi ^a   Nakajima, Shin Ichi ^a   Hagiwara, Eri ^c   Yamanokuchi, Hiroko ^a   Asari, Akira ^a  

^a SEIKAGAKU CORPORATION   (Japan)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Cell death; Double negative T cells; IL 12; Lymphoaccumulation; MRL lpr lpr mice

Indexed keywords

DIMER; GAMMA INTERFERON; INTERLEUKIN 12; MONOMER; NEUTRALIZING ANTIBODY; PROTEIN P40;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; IMMUNOMODULATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0034967844     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2000.0468     Document Type: Article

References (27)

1. Fas and Fas ligand: lpr and gld mutations
2. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
3. - double negative lymphocytes in autoimmune MRL-lpr/lpr mice
4. MRL-lpr/lpr disease: Theories meet Fas
5. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte mutation factor)
6. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
7. Differential effects of IL-12 receptor blockade with IL-12p40 homodimer on the induction of CD4+ and cD8+ IFN-γ-producing cells
8. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection
9. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo
10. A novel function of IL-12p40 as a chemotactic molecule for macrophages
11. + T cells creates double-negative cells in vivo
12. The abnormal T lymphocytes in lpr mice transcribe interferon-γ and tumor necrosis factor-α genes spontaneously in vivo
13. Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes
14. Intranasal immunization of a DNA vaccine with IL-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
15. Efficient selection for high-expression transfectants with a novel eukaryotic vector
16. Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12
17. + T cells from human immunodeficiency virus-infected persons
18. IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation
19. High dose oral tolerance in ovalbumin TCR-transgenic mice: Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis
20. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice
21. IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro
22. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL Mp-lpr/lpr mice
23. Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand Black/White F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain
24. IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice
25. Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
26. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice
27. Upregulation of lymphoid and renal interferon-γ mRNA in autoimmune MRL-Fas(lpr) mice with lupus nephritis