Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 3, 2001, Pages 419-430

  Iwakura, Atsushi ^a   Fujita, Masatoshi ^a   Hasegawa, Koji ^a   Toyokuni, Shinya ^a   Sawamura, Tatsuya ^b   Nohara, Ryuji ^a   Sasayama, Shigetake ^a   Komeda, Masashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Apoptosis; Cardiac myocyte; Ischemic heart disease; Oxidant stress; P38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CATALASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRATE; OXIDIZING AGENT; PROTEIN P53; SYNAPTOPHYSIN;

ADULT; AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FETUS; HEART MUSCLE CELL; HUMAN; ISCHEMIC HEART DISEASE; MALE; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PERICARDIAL EFFUSION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034965863     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1314     Document Type: Article

References (42)

1. Apoptosis, a basic biological phenomenon with wide-ranging implications in tissue kinetics
2. Programmed cell death in animal development
3. Apoptosis by death factor
4. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
5. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
6. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis
7. Apoptosis in ischemic and reperfused rat myocardium
8. Cardiac myocyte apoptosis: A new therapeutic target?
9. Myocyte nuclear mitotic division and programmed myocyte cell death characterize the Cardiac myopathy induced by rapid ventricular pacing in dogs
10. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure
11. Apoptosis in pressure overload-induced heart hypertrophy in the rat
12. Elevated basic fibroblast growth factor in pericardial fluid of patients with unstable angina
13. Marked elevation of brain natriuretic peptide levels in pericardial fluid is closely associated with left ventricular dysfunction
14. Induction of apoptosis of vascular endothelial cells by pericardial fluid of patients undergoing coronary artery bypass surgery
15. Endothelin Type A receptor-dependent signaling pathways inhibit β-adrenergic agonist-induced apoptosis in cardiac myocytes
16. 1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes
17. Gata-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes
18. α- and β-Adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes
19. Hyperglycemia causes oxidative stress in pancreatic b-cells of GK rats, a model of type 2 diabetes
20. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
21. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
22. Stress-activated protein kinases: Activation, regulation and function
23. Life, death and the pursuit of apoptosis
24. p53: A cell cycle regulator activated by DNA damage
25. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
26. Immediate early up-regulation of bax expression by p53 but not TGFβ1: A paradigm for distinct apoptotic pathways
27. Tumor suppressor p53 is a direct transcriptional activator of the human box gene
28. Hypoxia induces accumulation of p53 protein, but activation of G1-phase checkpoint by low-oxygen conditions is independent of p53 status
29. Molecular and biochemical reprogramming of oncogenesis through the activity of prooxidants and antioxidants
30. p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes
31. Hypoxia-mediated selection of cells with diminished apoptotic potential in tumors
32. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but ooccurs independently of p53
33. Mapks: New JNK expands the group
34. Parallel signal processing among mammalian MAPKs
35. How MAP kinases are regulated
36. Big mitogen-activated protein kinase I (BMKI) is a redox-sensitive kinase
37. Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
38. P38-2, a novel mitogen-activated protein kinase with distinct properties
39. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3(MKK6): Comparison of its substrate specificity with that of other SAP kinases
40. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
41. Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy
42. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia