Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer

European Journal of Cancer

Volumn 37, Issue 11, 2001, Pages 1372-1380

  Forsti A ^a   Louhelainen, J ^a   Soderberg M ^b   Wijkstrom H ^b   Hemminki, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bladder cancer; Breast cancer; Loss of heterozygosity; Normal tissue

Indexed keywords

MARKER;

ALLELE; ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; CARCINOGENESIS; CHROMOSOME 1; CHROMOSOME 13; CHROMOSOME 17; CHROMOSOME 3; CHROMOSOME 9; CLINICAL ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENETIC HETEROGENEITY; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; HUMAN TISSUE; MONOZYGOTIC TWINS; MUTATION; PRIORITY JOURNAL; SAMPLE; TUMOR;

BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 9; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; TWINS, MONOZYGOTIC; URINARY BLADDER NEOPLASMS;

EID: 0034961277     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(01)00118-6     Document Type: Article

References (45)

1. Lessons from hereditary colorectal cancer
2. Multistep carcinogenesis of breast cancer and tumour heterogeneity
3. Genetic progression, histological grade, and allelic loss in ductal carcinoma in situ of the breast
4. Comparative genomic hybridisation of ductal carcinoma in situ of the breast: Identification of regions of DNA amplification and deletion in common with invasive breast carcinoma
5. ABC of breast diseases. Carcinoma in situ and patients at high risk of breast cancer
6. Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium
7. Accumulated allelic losses in the development of invasive urothelial cancer
8. Allelotype of human bladder cancer
9. Two molecular pathways to transitional cell carcinoma of the bladder
10. Bladder cancer
11. Cancer in twins: Genetic and nongenetic familial risk factors
12. Allelic imbalance on chromosomes 13 and 17 and mutation analysis of BRCA1 and BRCA2 genes in monozygotic twins concordant for breast cancer
13. Use of twins in search for tumor suppressor genes
14. Allelic losses demonstrate monoclonality of multifocal bladder tumors
15. Initiation-development modelling of allelic losses on chromosome 9 in multifocal bladder cancer
16. Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors
17. Dinucleotide repeat polymorphism within the tumor suppressor gene PTCH at 9q22
18. Genetics of bladder cancer
19. Loss of heterozygosity in normal tissue adjacent to breast carcinomas
20. Superimposed histologic and genetic mapping of chromosome 17 alterations in human urinary bladder neoplasia
21. Human bladder cancers and normal bladder mucosa present the same hot spot of heterozygous chromosome-9 deletion
22. Detecting tumor-related alterations in plasma or serum DNA of patients diagnosed with breast cancer
23. Genetically abnormal clones in histologically normal breast tissue
24. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
25. Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer
26. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
27. Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast
28. Allelic imbalance on chromosome 1 in human breast cancer. II. Microsatellite repeat analysis
29. A region of allelic imbalance in 1q31-32 in primary breast cancer coincides with a recombination hot spot
30. Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13
31. Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors
32. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
33. Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer
34. Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 16q, 17p and 17q
35. Detailed deletion mapping of chromosome segment 17q12-21 in sporadic breast tumours
36. Closing in on a breast cancer gene on chromosome 17q
37. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations
38. Four tumor suppressor loci on chromosome 9q in bladder cancer: Evidence for two novel candidate regions at 9q22.3 and 9q31
39. PTCH gene mutations in invasive transitional cell carcinoma of the bladder
40. Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the P16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9
41. Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33
42. Mutation of the 9q34 gene TSC1 in sporadic bladder cancer
43. Minimal deletion of 3p13-> 14.2 associated with immortalization of human uroepithelial cells
44. Chromosome 3 allelic losses and microsatellite alterations in transitional cell carcinoma of the urinary bladder
45. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization