Minimal deletion of 3p13 → 14.2 associated with immortalization of human uroepithelial cells

Genes Chromosomes and Cancer

Volumn 21, Issue 1, 1998, Pages 39-48

  Vieten, Lydia ^a   Beiair, Cassandra D ^b   Savelieva, Lena ^b   Jülicher, Knut ^a   Bröcker, Frank ^a   Bardenheuer, Walter ^a   Schütte, Jochen ^a   Opalka, Bertram ^a   Reznikoff, Catherine A ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CELL IMMORTALIZATION; CHROMOSOME 3P; CHROMOSOME DELETION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; UROTHELIUM; WART VIRUS; YEAST ARTIFICIAL CHROMOSOME;

CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CHROMOSOME DELETION; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 3; CULTURE TECHNIQUES; EPITHELIAL CELLS; GENETIC MARKERS; HUMANS; KARYOTYPING; NUCLEIC ACID HYBRIDIZATION; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; URETER;

HUMAN PAPILLOMA VIRUS; HUMAN PAPILLOMAVIRUS TYPES;

EID: 0031964287     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199801)21:1<39::AID-GCC6>3.0.CO;2-9     Document Type: Article

References (67)

1. Anwar K, Naiki H, Nakakuki K, Inuzuka M (1992) High frequency of human papilloma virus infection in carcinoma of the urinary bladder. Cancer 70: 1967-1973.
2. Bardenheuer W, Szymanski S, Lux A, Lüdecke HJ, Horsthemke B, Claussen U, Senger G, Smith DI, Wang ND, LePaslier D, Cohen D, Heppell-Parton A, Rabbitts P, Schütte J, Opalka B (1994) Characterization of a microdissection library from human chromosome region 3p14. Genomics 19: 291-297.
3. Bardenheuer W, Michaelis S, Lux A, Vieten L, Bröcker F, Jülicher K, Willers C, Siebert R, Smith DI, van der Hout AH, Buys CJ, Schütte J, Opalka B (1996) Construction of a consistent YAC contig for human chromosome region 3p14.1. Genome Res 6: 176-186.
4. Belair C, Blelloch RH, Reznikoff CA (1996) Immortalization of human uroepithelial cells by human papilloma virus 16 E6 or E7. Radiat Oncol Invest 3: 368-376.
5. Bergerheim U, Nordenskjöld M, Collins V (1989) Deletion mapping in human renal cell carcinoma. Cancer Res 49: 1390-1396.
6. Boldog FL, Gemmill RM, Wilke CM, Glover TW, Nilsson AS, Chandrasekharappa SC, Brown RS, Li FP, Drabkin HA (1993) Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint. Proc Natl Acad Sci USA 90: 8509-8513.
7. Boyer SN, Wazer DE, Band V (1996) E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasomc pathway. Cancer Res 56: 4620-4624.
8. Brauch H, Johnson B, Hovi J, Yano T, Gazdar A, Pettengill O, Graziano S, Sorenson G, Poiesz B, Minna J, Linehan M, Zbar B (1987) Molecular analysis of the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. N Engl J Med 317: 1109-1113.
9. Cairns P, Mao L, Merlo A, Lee DJ, Schwab D, Eby Y, Tokino K, van der Riet P, Blaugrund JE, Sidranski D (1994) Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science 265: 415-416.
10. Chung GT, Sundaresan V, Hasleton P, Rudd R, Taylor R, Rabbitts PH (1995) Sequential molecular genetic changes in lung cancer development. Oncogene 11: 2591-2598.
11. Devilee P, van den Broek M, Kuipers-Dijkshoorn N, Kolluri R, Khan P, Pearson P, Cornelisse CJ (1989) At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma. Genomics 5: 554-560.
12. Ehlen T, Dubeau L (1990) Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas. Oncogene 5: 219-223.
13. Gemmill RM, Chumakov I, Scott P, Waggoner B, Rigault P, Chen Q, Weissenbach J, Gardiner K. Wang H, Pekarsky V, Le Gall I, Le Paslier D, Guillou S, Li E, Robinson L, Hahner L, Todd S, Cohen D, Drabkin HA (1995) A second-generation YAC contig map of human chromosome 3. Nature 377: 299-319.
14. Habuchi T, Ogawa O, Kakehi Y, Ogura K, Oshiba M, Hamazaki S, Takahashi R, Sugiyama T, Oshida Y (1993) Accumulated allelic losses in the development of invasive urothelial cancer. Int J Cancer 53: 579-584.
15. Halbert CL, Bemers GW, Galloway DA (1991) The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol 65: 473-478.
16. Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y, Takahashi T (1992) Three distinct regions involved in 3p deletion in human lung cancer. Oncogene 7: 445-449.
17. Horio Y, Takahashi T, Kuroishi T, Hibi K, Suyama M, Niimi T, Shimokata K, Yamakawa K, Nakamura Y, Uedo R, Takahashi T (1993) Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer. Cancer Res 53: 1-4.
18. Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire D, Minna JD, Gazdar AF (1995) Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. JAMA 15: 558-563.
19. Jones MH, Koi S, Fujimoto I, Hasumi K, Kato K, Nakamura Y (1994) Allelotype of uterine cancer by analysis of RKLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q and 17p. Genes Chromosomes Cancer 9: 119-123.
20. Jülicher K, Vieten L, Bröcker F, Bardenheuer W, Schütte J, Opalka B (1997) Yeast artificial chromosome transfer into human renal carcinoma cells by spheroplast fusion. Genomics 43: 95-98.
21. Kallioniemi A, Kallioniemi O-P, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (1994) Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA 91: 2156-2160.
22. Kallioniemi A, Kallioniemi O-P, Citro G, Sauter G, deVries S, Kerschmann R, Carall P, Waldman F (1995) Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization. Genes Chromosomes Cancer 12: 213-219.
23. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stokert E, Day RS III, Johnson BE, Skolnick MH (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 246: 436-440.
24. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
25. Klingelhutz AJ, Barber SA, Smith PP, Dyer K, McDougall JK (1994) Restoration of telomeres in human papilloma virus-immortalized human anogenital epithelial cells. Mol Cell Biol 14: 961-969.
26. Knowles MA, Elder PA, Williamson M, Cairns JP, Shaw ME, Law MG (1994) Allelotype of human bladder cancer. Cancer Res 54: 531-538.
27. Kohno T, Takayama H, Hamaguchi M, Takano H, Yamaguchi N, Tsuda H, Hirohashi S, Vissing H, Shimizu M, Oshimura M, Yokota J (1993) Deletion mapping of chromosome 3p in human uterine cervical cancer. Oncogene 8: 1825-1832.
28. LaRue H, Simoneau M, Fradet Y (1995) Human papilloma virus in transitional cell carcinoma of the urinary bladder. Clin Cancer Res 1: 435-440.
29. Latif F, Fivash M, Glenn G, Tory K, Orcutt M, Hampsch K, Delisio J, Lerman M, Cowan J, Beckett M, Weichselbaum R (1992) Chromosome 3p deletions in head and neck carcinomas: Statistical ascertainment of allelic loss. Cancer Res 52: 1451-1456.
30. Latif F, Tory K, Gnarra J, Yao M, Dun F-M, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakow I, Cohen D, Chinault CA, Maher ER, Linehan WM, Zbar B, Lerman MI (1993) Isolation of the von-Hippel-Lindau disease tumor suppressor gene. Science 260: 1317-1320.
31. Lothe R, Fossa S, Stenwig A, Nakamura Y, White R, Borresen A, Brogger A (1989) Loss of 3p or 11p alleles is associated with testicular cancer tumors. Genomics 5: 134-138.
32. Lux A, Bardenheuer W, Michael D, Brocker F, Jülicher K, Vieten L, Michaelis S, Seeber S, Opalka B, Schütte J (1997) Identification of novel "expressed sequence tags" within the FHIT gene locus in human chromosome region 3p14.2. Hum Genet 100: 90-95.
33. Mao L, Lee JS, Fan YH, Ro JY, Batsakis JG, Lippman S, Hittelman W, Hong WK (1996) Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nat Med 2: 682-685.
34. Michaelis SC, Bardenheuer W, Lux A, Schramm A, Gockel A, Siebert R, Willers C, Schmidtke K, Todt B, van der Horn AH, Buy CHCM, Heppell-Parton AC, Rabbitts PH, Unger S, Smith D, LePaslier D, Cohen D, Opalka B, Schütte J (1995) Characterization and chromosomal assignment of yeast artificial chromosomes containing human 3p13-p21-specific sequence tagged sites. Cancer Genet Cytogenet 81: 1-12.
35. Morita R, Ishikawa J, Tutsumi M, Hikiji K, Tsukada Y, Kamidono S, Maeda S, Nakamura Y (1991) Allelotype of renal cell carcinoma. Cancer Res 51: 820-823.
36. Munger K, Scheffner M, Huibregtse JM, Howley PM (1992) Interactions of HPV E6 and E7 oncoproteins with tumor suppressor gene products. Cancer Surv 12: 197-217.
37. Naylor S, Johnson B, Minna J, Sakaguehi A (1987) Loss of heterozygosity of chromosome 3 markers in small-cell lung cancer. Nature 329: 451-454.
38. Negrini M, Monaco C, Vorechovski I, Ohta M, Druck T, Baffa R, Huebner K, Croce CM (1996) The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res 56: 3173-3179.
39. Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC, Oshimura M (1995) Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86: 899-904.
40. Ohta M, Hiroshi I, Grazia M, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue R Druck T, Croce CM, Huebner K (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84: 587-597.
41. Presti JC Jr, Reuter VE, Galan T, Fair WR, Cordon-Cordo C (1991) Molecular genetic alterations in superficial and locally advanced human bladder cancer. Cancer Res 51: 5405-5409.
42. Reznikoff CA, Loretz LJ, Presciotta DM, Oberley TD, Ignjatovic MM (1987) Growth kinetics and differentiation in vitro of normal human uroepithelial cells on collagen gel substrates in defined medium. J Cell Physiol 131: 285-301.
43. Reznikoff CA, Kao C, Messing F.M, Newton M, Swaminathan S (1993) A molecular genetic model of human bladder carcinogenesis. Semin Cancer Biol 4: 143-152.
44. Reznikoff CA, Belair CD, Savelieva E, Zhai Y, Pfeifer K, Yeager T, Thompson KJ, DeVries S, Bindley C, Newton MA, Sekhon G, Waldman F (1994) Long-term genome stability and minimal genotypic and phenotypic alterations in HPV E7-, but not E6-, immortalized human uroepithelial cells. Genes Dev 8: 2227-2240.
45. Reznikoff CA, Belair CD, Yeager TR, Savelieva E, Blelloch RH, Puthenveettil JA, Cuthill S (1996) A molecular genetic model of human bladder cancer pathogenesis. Semin Oncol 23: 571-584.
46. Roz L, Wu CL, Poerter S, Scully C, Speight P, Read A, Sloan P, Thakker N (1996) Allelic imbalance on chromosome 3p in oral dysplastic lesions: An early event in oral carcinogenesis. Cancer Res 56: 1228-1231.
47. Sanchez Y, El-Naggar A, Pathak S, Killary AMN (1994) A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci USA 91: 3383-3387.
48. Sato T, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y (1991) Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res 51: 5794-5799.
49. Savelieva E, Belair CD, Newton MA, DeVries S, Gray JW, Waldman F, Reznikoff CA (1996) 20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papilloma virus 16 E7 immortalized human uroepithelial cells. Oneogene 14: 551-560.
50. Seachrist L (1995) Telomcres draw a crowd at Toronto cancer meeting. Science 268: 29-30.
51. Shay JW, Wright WE, Werbin H (1991) Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1072: 1-7.
52. Smeets DF, Scheres JM, Hustinx TW (1986) The most common fragile site in man is 3p14. Hum Genet 72: 215-220.
53. Smith SE, Joseph A, Nadeau S, Shridhar V, Gemmill R, Drabkin H, Knuutila S, Smith D (1993) Cloning and characterization of the human t(3;6)(p14;p11) translocation breakpoint associated with hematologic malignancies. Cancer Genet Cytogenet 71: 153-161.
54. Sozzi G, Alder H, Tornielli S, Corletto V, Baffa R, Veronese ML, Negrini M, Pilotti S, Pierotti MA, Huebner K, Croce CM (1996a) Aberrant FHIT transcripts in Merkel cell carcinoma. Cancer Res 56: 2472-2474.
55. Sozzi G, Veronese ML, Negrini M, Baffa RM, Cotticelli G, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM (1996b) The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell 85: 17-26.
56. Spruck CH III, Gonzalez-Zulueta M, Shibata AR, Simoneau MF, Lin F, Gonzales F, Tsai YC, Jones PA (1994a) p16 gene in uncultured tumors. Nature 370:183-184.
57. Spruck CH III, Ohneseit PF, Gonzalez-Zulueta M, Esrig D, Miyao N, Tsai YC, Lerner SP, Schmutte C, Yang AS, Cote R, Dubeau L, Nichols PW, Hermann GG, Steven K, Horn T, Skinner DG, Jones PA (1994b) Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res 54: 784-788.
58. Steenbergen RDM, Walboomers JMM, Meijer CJLM, van der Raaj-Helmer EMH, Parker JN, Chow LT, Broker TR, Snijders PJF (1996) Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes toward immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene 13: 1249-1257.
59. Todd S, Roche J, Hahner L, Bolin R, Drabkin HA, Gemmill R (1995) YAC contigs covering an 8-megabase region of 3p deleted in the small-cell lung cancer cell line U2020. Genomics 25: 19-28.
60. Uzawa N, Yoshida MA, Oshimaura M, Ikeuchi T (1995) Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Oncogene 11: 1997-2004.
61. van den Berg A, van der Veen AY, Hulsbeek MMF, Kovacs G, Gemmill RM, Drabkin HA, Buys CHCM (1995) Defining the position of the breakpoint of the constitutional t(3;6) occurring in a family with renal cell carcinoma. Genes Chromosomes Cancer 12: 224-228.
62. Virgilio L, Shuster M, Gollini SM, Veronese ML, Ohta M, Huebner K, Croce CM (1996) FHIT gene alterations in head and neck squamous cell carcinomas. Proc Natl Acad Sci USA 93: 9770-9775.
63. Whang-Peng J, Knutsen T, Douglass E, Chu E, Ozols R, Hogan W, Young R (1984) Cytogenctic studies in ovarian cancer. Cancer Genet Cytogenet 11: 91-106.
64. Wilhelm M, Bugert P, Kenck G, Kovacs G (1996) The FHIT gene is not involved in the development of nonpapillary renal cell carcinomas. Am J Hum Genet 59: A85.
65. Wilke CM, Hall BK, Paradee W, Smith DI, Glover TW (1996) FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: Direct evidence for the coincidence of viral integration sites and fragile sites. Hum Mol Genet 5: 187-195.
66. Yokoyama S, Yamakawa K, Tsuchiya E, Murata M, Sekiyama S, Nakamura Y (1992) Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res 52: 873-877.
67. Zbar B, Branch H, Talmadge C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327: 721-724.