Secured cutting: Controlling separase at the metaphase to anaphase transition

EMBO Reports

Volumn 2, Issue 6, 2001, Pages 487-492

  Uhlmann, F ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COHESIN; PROTEIN SUBUNIT; PROTEINASE; SCC1 PROTEIN; SEPARASE; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; CELL DIVISION; CHROMATID; CHROMOSOME PAIRING; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; EUKARYOTE; GENE REPLICATION; GENETIC CONSERVATION; METAPHASE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW;

ACTINOBACTERIA (CLASS); ANIMALIA; EUKARYOTA; UNCULTURED ACTINOMYCETE;

EID: 0034959766     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve113     Document Type: Review

References (49)

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3. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
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7. Checkpoints controlling mitosis
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13. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes
14. Cut2 proteolysis required for sister-chromatid separation in fission yeast
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31. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
32. Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20
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40. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
41. Sister chromatid cohesion and recombination in meiosis
42. Two distinct pathways remove mammalian cohesin complexes from chromosome arms in prophase and from centromeres in anaphase
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44. The Drosophila RAD21 cohesin persists at the centromere region in mitosis
45. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
46. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
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