Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects

Metabolism: Clinical and Experimental

Volumn 48, Issue 2, 1999, Pages 269-274

  Ubbink, Johan B ^a   Christianson, Arnold ^b   Bester, Megan J ^b   Van Allen, Margot I ^b   Venter, Philip A ^b   Delport, Rhena ^b   Blom, Henk J ^b   Van Der Merwe, Annatjie ^b   Potgieter, Hendrik ^b   Vermaak, W J Hayward ^b  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; GENE MUTATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NEURAL TUBE DEFECT; PATHOGENESIS; PREGNANCY COMPLICATION; PREVALENCE; PRIORITY JOURNAL; SOUTH AFRICA;

EID: 13044249173     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90046-X     Document Type: Article

References (35)

1. Ncayiyana DJ: Neural tube defects among rural blacks in a Transkei district. S Afr Med J 69:618-620, 1986
2. Venter PA, Christianson AL, Hutamo CM, et al: Congenital anomalies in rural black South African neonates - A silent epidemic? S Afr Med J 85:15-20, 1995
3. Buccimazza SS, Molteno CD, Dunne TT, et al: Prevalence of neural tube defects in Cape Town, South Africa. Teratology 50:194-199, 1994
4. Delport SD. Christianson AL, Van den Berg HJS, et al: Congenital anomalies in black South African liveborn neonates born in an urban academic hospital. S Afr Med J 85:11-15, 1995
5. Medical Research Council Research Group: Prevention of neural tube defects: Results of the Medical Research Council vitamin study. Lancet 338:131-137, 1991
6. Czeizel AE, Dudas I: Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832-1835, 1992
7. Kirke PN, Molloy AM. Daly LE, et al: Maternal plasma folate and vitamin B-12 are independent risk factors for neural tube defects. Q J Med 86:703-708, 1993
8. Daly LE, Kirke PN, Molloy A, et al: Folate levels and neural tube defects. Implications for prevention. JAMA 274:1698-1702, 1995
9. Wald NJ, Hackshaw AK, Stone R, et al: Blood folic acid and vitamin B-12 in relation to neural tube defects. Br J Obstet Gynaecol 103:319-324, 1996
10. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al: Maternal hyperhomocysteinemia: A risk factor for neural-tube defects? Metabolism 43:1475-1480, 1994
11. Mills JL, McPartlin JM, Kirke PN, et al: Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 345:149-151, 1995
12. Lucock MD, Wild J. Lumb CH, et al: Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate: homocysteine methyltransferase. Biochem Mol Med 61:28-40, 1997
13. Steegers-Theunissen RP, Boers GH, Blom HJ, et al: Neural tube defects and elevated homocysteine levels in ammotic fluid. Am J Obstet Gynecol 172:1436-1441, 1995
14. Van der Put NMJ, Steegers-Theunissen RPM. Frosst P, et al: Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071, 1995
15. Ou CY, Stevenson RE. Brown VK, et al: 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 63:610-614, 1996
16. Frosst P, Blom HJ, Milos R, et al: A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113, 1995
17. Nishio H, Lee MJ, Fujii M, et al: A common mutation in methylenetetrahydrofolate reductase gene among the Japanese popula-tion. Jpn J Hum Genet 41:247-251, 1996
18. Jacques PF, Bostom AG, Williams RR, et al: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation 93:7-9, 1996
19. Harmon DL, Woodside JV, Yarnell JW, et al: The common "thermolabile" variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q J Med 89:571-577, 1996
20. Malinow MR, Nieto FJ, Kruger WD, et al: The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vasc Biol 17:1157-1162, 1997
21. Lindenbaum J, Healton EB, Savage DG, et al: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318:1720-1728, 1988
22. 12 are independent risk factors for neural tube defects. Q J Med 86:703-708, 1993
23. 12 metabolism in families with spina bifida offspring. Q J Med 90:505-510, 1997
24. Baynes RD, Meriwether WD, Bothwell TH, et al: Iron and folate status of pregnant black women in Gazankulu. S Afr Med J 70:148-151, 1986
25. Van der Westhuyzen J, van Tonder S, Gilbertson I, et al: Iron, folate and vitamin B12 nutrition and anaemia in black preschool children in the northern Transvaal. S Afr Med J 70:143-145, 1986
26. Ubbink JB, Serfontein WJ, de Villiers LS: Stability of pyridoxal5-phosphate semicarbazone: Application in plasma vitamin B-6 analysis and population surveys of vitamin B-6 nutritional status. J Chromatogr 342:277-284, 1985
27. Araki A, Sako Y: Determination of free and total homocysteine in human plasma by HPLC with fluorescence detection. J Chromatogr 422:43-52, 1987
28. Ubbink JB, Vermaak WJH. Bissbort S: Rapid high-performance liquid Chromatographic assay for total homocysteine levels in human serum. J Chromatogr 565:441-446, 1991
29. Potgieter HC, Ubbink JB, Bissbort S, et al: Spontaneous oxidation of methionine: Effect on the quantification of plasma methionine levels. Anal Biochem 248:86-93, 1997
30. Johns MB, Paulus-Thomas JE: Purification of human genomic DNA from whole blood using sodium perchlorate in place of phenol. Anal Biochem 180:276-278, 1989
31. Kluijtmans LAJ, Van den Heuvel LPWJ, Boers GHJ, et al: Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 58:35-41, 1996
32. Bourne LT, Bourne DE, Sayed AR, et al: Folate levels in an urban population - implications for supplementation for the prevention of neural tube defects. S Afr Med J 87:932-933, 1997
33. Allen WP: Folic acid in the prevention of birth defects. Curr Opin Pediatr 8:630-634, 1996
34. Ubbink JB, Vermaak HJH, van der Merwe A, et al: Effective homocysteine metabolism may protect South African blacks against coronary heart disease. Am J Clin Nutr 62:802-808, 1995
35. McAndrew PE, Brandt JT, Pearl DK, et al: The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans. Thromb Res 83:195-198, 1996