S-methyl-L-thiocitrulline counteracts interleukin 1β-induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo

Cytokine

Volumn 9, Issue 5, 1997, Pages 352-359

  Sternesjö, Johnny ^a   Welsh, Nils ^a   Sandler, Stellan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Insulin secretion; Interleukin I; Pancreatic islets; S methyl L thiocitrulline; Streptozotocin; cells

Indexed keywords

CITRULLINE; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; METHYL GROUP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PROINSULIN; STREPTOZOCIN; THIOL GROUP;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULITIS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALIA;

EID: 0031149169     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0176     Document Type: Article

References (41)

1. 1. Nerup J, Mandrup-Poulsen T, Mølvig J, Helqvist S, Egeberg J (1988) Mechanism of pancreatic β-cell destruction in type 1 diabetes. Diabetes Care 11(Suppl. 1):16-23.
2. 2. Mandrup-Poulsen T, Helquist S, Wogensen LD, Mølvig J, Pociot F, Johannesen J, Nerup J (1990) Cytokines and free radicals as effector molecules in the destruction of the pancreatic beta cell. Curr Top Microbiol Immunol 164:169-193.
3. 3. Sandler S, Eizirik DL, Svensson C, Strandell E, Welsh M, Welsh N (1991) Biochemical and molecular actions of interleukin-1 on pancreatic β-cells. J Autoimmunity 10:241-253.
4. 4. Eizirik DL, Cagliero E, Björklund A, Welsh N (1992) Interleukin-1β induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages. FEBS Lett 308:249-252.
5. 5. Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML (1995) Interleukin-1 β-induced nitric oxide synthase expression by rat pancreatic β-cells: evidence for the involvement of nuclear factor KB in the signalling mechanism, Endocrinology 136: 4790-4795.
6. 6. Welsh N, Eizirik DL, Sandler S (1994) Nitric oxide and pancreatic β-cell destruction in insulin dependent diabetes mellitus: don't take NO for an answer, J Autoimmunity 18:285-290.
7. 7. Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood R, Oplinger JA, Garvey EP (1994) Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline. J Biol Chem 269:26677-26683.
8. 8. Southern C, Schulster D, Green IC (1990) Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via an L-arginine-dependent nitric oxide generating mechanism. FEBS Lett 276:42-44.
9. 9. Welsh N, Eizirik DL, Bendtzen K, Sandler S (1991) Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of Krebs cycle enzyme aconitase. Endocrinology 129:3161-3173.
10. 10. Corbett JA, McDaniel ML (1992) Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 41:897-903.
11. 11. Corbett JA, Wang JL, Sweetland MA, Lancaster Jr. JR, McDaniel ML (1992) Interleukin-1β induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. J Clin Invest 90:2384-2391.
12. G-monomethyl-L-arginine. FEBS Lett 299:103-106.
13. 13. Narayanan K, Griffith OW (1994) Synthesis of L-thiocitrulline, L-homothiocitrulline: a new class of potent nitric oxide synthase inhibitors. J Med Chem 37:885-887.
14. 14. Andersen HU, Jørgensen KH, Egeberg J, Mandrup-Poulsen T, Nerup J (1994) Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production by rat islets of Langerhans. Diabetes 43:770-777.
15. 15. Suarez-Pinzon WL, Stryndaka K, Schulz R, Rabinovitch A (1994) Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide. Endocrinology 134: 1006-1010.
16. 16. Hausladen A, Fridovich I (1994) Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J Biol Chem 269:29405-29408.
17. 17. Castro L, Rodriguez M, Radi R (1994) Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J Biol Chem 269:29409-29415.
18. 18. Eizirik DL, Sandler S, Welsh N, Cetkovic-Cvrlje M, Nieman A, Geller DA, Pipeleers DG, Bendtzen K, Hellerström C (1994) Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 93:1968-1974.
19. 19. Rabinovitch A, Suarez-Pinzon WL, Stryndaka K, Schulz R, Lakey JR, Warnock GL, Rajotte RV (1994) Human pancreatic islet β-cell destruction by cytokines is independent of nitric oxide production. J Clin Endocr Metab 79:1058-1062.
20. G-nitro-L-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas. Endocrinology 128:3081-3085.
21. 21. Panagiotidis G, Åkesson B, Rydell EL, Lundquist I (1995) Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues. Br J Pharmacol 114:289-296.
22. 22. Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F (1991) Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255:721-723.
23. 23. Blachier F, Leclerq-Meyer V, Marchand J, Woussen-Colle M-C, Mathias PCF, Sener A, Malaisse WJ (1989) Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to L-arginine and L-ornithine. Biochim Biophys Acta 1013:144-151.
24. 24. Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: a new model of diabetes mellitus. Science 193:415-417.
25. 25. Lukic ML, Stosic-Grujicic S, Ostojic N, Chan WL, Liew FY (1991) Inhibition of nitric oxide generation affects the induction of diabetes by streptozotocin in mice. Biochem Biophys Res Commun 178:913-920.
26. 26. Kolb H, Kiesel U, Kröncke K-D, Kolb-Bachofen V (1993) Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci 49:213-217.
27. 27. Holstad M, Sandler S (1993) Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice. J Autoimmunity 15:311-314.
28. G-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes 44: 360-364.
29. ω-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats. Diabetes 44: 365-368.
30. 30. Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unaue ER (1993) Nitric oxide production in islets of nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci USA 90:8992-8995.
31. 31. Bowman M, Simell O, Look Z, Luchetta R, Atkinson M (1994) Pharmacokinetic and therapeutic analysis of aminoguanidine (AG) in non-obese diabetic (NOD) mice. Diabetes 43 (Suppl. 1):235A.
32. 32. Welsh M, Welsh N, Bendtzen K, Mares J, Strandell E, Öberg C, Sandler S (1995) Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38:153-160.
33. 33. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC (1996) Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS-expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137:2093-2099.
34. 34. Sandler S, Andersson A (1985) Modulation of streptozotocin-induced insulitis and hyperglycemia in the mouse. Acta Path Microbiol Immunol Scand Sect [A] 412:225-230.
35. 35. Sandler S, Andersson A, Hellerström C (1987) Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis and oxidative metabolism of rat pancreatic islets. Endocrinology 121:1424-1431.
36. 36. Krebs HA, Henseleit K (1932) Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe-Seylers Z Physiol Chem 210:33-66.
37. 37. Heding LG (1972) Determination of total serum insulin (IRI) in insulin-treated patients. Diabetologia 8:260-266.
38. 38. Hinegardner RT (1971) An improved fluorometric assay for DNA. Anal Biochem 39:197-201.
39. 39. Andersson A, Sandler S (1983) Viability tests of cryopreserved endocrine pancreatic cells. Cryobiology 20:161-168.
40. 40. Halban PA, Wollheim CB, Blondel B, Renold AE (1980) Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the β-cell. Biochem Pharmacol 29:2625-2633.
41. 15N]nitrate in biological fluids. Anal Biochem 126:131-138.