All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level β-lactam-resistant clinical isolate of Streptococcus mitis

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 7, 2001, Pages 2075-2081

  Amoroso, A ^a   Demares, D ^a   Mollerach, M ^a   Gutkind, G ^a   Coyette, J ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; BETA LACTAM; CEFALEXIN; CEFALORIDINE; CEFALOTIN; CEFOPERAZONE; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; DICLOXACILLIN; OXACILLIN; PENICILLIN BINDING PROTEIN; PENICILLIN G; PIPERACILLIN; SERINE; TRACER;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; DENSITOMETRY; GENE STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; STREPTOCOCCUS MITIS; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CARRIER PROTEINS; DNA, BACTERIAL; GENE AMPLIFICATION; HEXOSYLTRANSFERASES; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR WEIGHT; MULTIENZYME COMPLEXES; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS; SUPEROXIDE DISMUTASE;

EID: 0034956280     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.7.2075-2081.2001     Document Type: Article

References (53)

1. Streptococcal and enterococcal bacteremia in patients with cancer
2. Bacteremia due to viridans streptococci in neutropenic patients with cancer: Clinical spectrum and risk factors
3. In vitro susceptibility to antibiotics of 200 strains of streptococci and enterococci isolated during infective endocarditis
4. Bacteremia due to viridans streptococci that are highly resistant to penicillin: Increase among neutropenic patients with cancer
5. Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis
6. Classification and identification of the viridans streptococci
7. Emergence of high rates of antimicrobial resistance among viridans group streptococci in the United States
8. Identity of viridans streptococci isolated from cases of infective endocarditis
9. Horizonal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae
10. Penicillin resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae
11. Horizontal gene transfer and the evolution of resistance and virulence determinants in Streptococcus
12. Evolution of penicillin resistance in Streptococcus pneumoniae: The role of Streptococcus mitis in the formation of a low affinity PBP 2B in Streptococcus pneumoniae
13. Extensive remodelling of the transpeptidase domain of penicillin binding protein 2B of a penicillin resistant South African isolate of Streptococcus pneumoniae
14. Penicillin binding proteins, wall peptidoglycan assembly and resistance to penicillin: Facts, doubts and hopes
15. Penicillin and beyond: Protein fold, multimodular polypeptides and multiprotein complexes
16. The multimodular penicillin-binding proteins: An enigmatic family of orthologs and paralogs
17. Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of β-lactam antibiotics
18. Prevalence of penicillin-resistant viridans streptococci in healthy children and in patients with malignant haematological disorders
19. Target-mediated resistance to β-lactam antibiotics
20. Mosaic genes and their role in penicillin-resistant Streptococcus pneumoniae
21. r penicillin-binding protein variants during transfer of high-level β-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae
22. Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants
23. β-Lactam resistance in Streptococcus pneumoniae: Penicillin-binding proteins and non-penicillin-binding proteins
24. Recent developments in streptococcal taxonomy: Their relation to infections
25. Viridans streptococci isolated from the bloodstream
26. Determination of 16S RRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of genus Streptococcus
27. Genetic approaches to the identification of the mitis group Within the genus Streptococcus
28. Comparison of phenotypic characteristics, DNA-DNA hybridization results, and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci
29. Streptococcus mitis with unusually high-level resistance to β-lactam antibiotics
30. Penicillin-binding proteins 2x and 2b as primary PBP targets in Streptococcus pneumoniae
31. Nucleotide sequence of the pbpX gene encoding the penicillin-binding protein 2X from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506
32. Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae
33. Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae
34. Rapid determination of 16S ribosomal RNA segments for phylogenetic analyses
35. Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1A and 2B
36. Relatedness of penicillin-binding protein 1A genes from different clones of penicillin-resistant Streptococcus pneumoniae isolated in South Africa and Spain
37. 125I-radiolabeled penicillin for penicillin-binding protein studies
38. Identification of a structural determinant for resistance to β-lactam antibiotics in Gram-positive bacteria
39. Identification of streptococci to species levels by sequencing the gene encoding the manganese-dependent superoxide dismutase
40. Serious infections due to penicillin-resistant strains of viridans streptococci with altered penicillin-binding proteins
41. A global gene pool for high-level cephalosporin resistance in commensal Streptococcus species and Streptococcus pneumoniae
42. DNA sequencing with chain-terminating inhibitors
43. Streptocoques et genres apparentés: Abiotrophes et enterocoques
44. Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis
45. Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae
46. Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species
47. Antimicrobial susceptibility of viridans group streptococci
48. 16S ribosomal DNA amplification for phylogenetic study
49. Genetic relationships between clinical isolates of Streptococcus pneumoniae, Streptococcus oralis, and Streptococcus mitis: Characterization of "atypical" pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding genes
50. Current classification of the oral streptococci
51. Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to β-lactam antibiotics