Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria

IUBMB Life

Volumn 51, Issue 2, 2001, Pages 99-104

  Elholm, M ^a   Hollas H ^a   Issalene, C ^a   Viegas Barroso, J F ^a   Berge, R K ^a   Flatmark, T ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Deoxyribonucleoside metabolism; Etradecylthioacetic acid; Mitochondrial biogenesis; MtDNA replication; NMRI mice; Thymidine kinase

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; FATTY ACID DERIVATIVE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; THIOACETIC ACID; THYMIDINE; THYMIDINE KINASE; TRITIUM;

ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME REGULATION; LIVER CELL; LIVER MITOCHONDRION; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PEROXISOME;

EID: 0034954559     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540152122094     Document Type: Article

References (51)

1. Mitochondrial DNA maintenance in vertebrates
2. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma
3. Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the expressed sequence tags database
4. Purification and characterization of human mitochondrial transcription factor 1
5. Mammalian deoxyribonucleoside kinases
6. Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis
7. Thyroid hormone regulation of mitochondrial function. Comments on the mechanism of signal transduction
8. Brown adipose tissue thermogenesis: Interdisciplinary studies
9. Mitochondrial diseases in man and mouse
10. Alkylthioacetic acids (3-thia fatty acids) as non-beta-oxidizable fatty acid analogues: A new group of hypolipidemic drugs. III. Dissociation of cholesterol- and triglyceride-lowering effects and the induction of peroxisomal beta-oxidation
11. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
12. Thio fatty acids, metabolism and metabolic effects
13. Morphologic effects of sulfur-substituted fatty acids on rat hepatocytes with special reference to proliferation of peroxisomes and mitochondria
14. Alkylthioacetic acid (3-thia fatty acids)a new group of non-beta-oxidizable, peroxisome-inducing fatty acid analogues. I. A study on the structural requirements for proliferation of peroxisomes and mitochondria in rat liver
15. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferatoractivated receptor alpha (PPARalpha)
16. Cloning and characterization of full-length mouse thymidine kinase 2: The N-terminal sequence directs import of the precursor protein into mitochondria
17. Conditions in vitro which affect respiratory control and capacity for respiration-linked phosphorylation in brown adipose tissue mitochondria
18. A fluorometric assay of acyl-CoA oxidase activity by a coupled peroxidatic reaction: Elimination of interfering side reactions
19. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
20. Evidence that deletion of coding sequences in the 5′ end of the thymidine kinase gene of herpes simplex virus type I affects the stability of the gene products
21. Time-dependent effects of the hypolipidemic agent clofibrate on peroxisomes and mitochondria in mouse hepatocytes
22. Effects of clofibrate withdrawal on peroxisomes in mouse hepatocytes
23. Protonophoric activity of fatty acid analogs and derivatives in the inner mitochondrial membrane: A further argument for the fatty acid cycling model
24. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression
25. Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: Relationship to mitochondrial alterations
26. Human deoxythymidine kinase II: Substrate specificity and kinetic behavior of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia
27. Kinetic mechanism and end-product regulation of deoxyguanosine kinase from beef liver mitochondria
28. Mitochondrial toxicity of antiviral drugs
29. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts
30. Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event
31. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells
32. Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2
33. A deoxyribonucleotidase in mitochondria: Involvement in regulation of dNTP pools and possible link to genetic disease
34. Fatty acid metabolism in liver of rats treated with hypolipidemic sulphur-substituted fatty acid analogues
35. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
36. Survey of amino-terminal proteolytic cleavage sites in mitochondrial precursor proteins: Leader peptides cleaved by two matrix proteases share a three-amino acid motif
37. Human thymidine kinase 2: Molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates
38. Human deoxycytidine kinase is located in the cell nucleus
39. Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes
40. Regulation of thymidine kinase synthesis in human cells
41. Immunohistochemical detection of proliferating cells in vivo
42. Thymidine kinases: The enzymes and their clinical usefulness
43. Overexpression of thymidine kinase mRNA eliminates cell cycle regulation of thymidine kinase enzyme activity
44. The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: Glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis
45. Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: Role of PPARalpha and TNFalpha
46. A cold inducible coactivator of nuclear receptors linked to adaptive thermogenesis
47. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
48. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
49. Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme
50. Peroxisome proliferator-activated receptors: Nuclear control of metabolism