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Volumn 243, Issue 2, 1998, Pages 340-353

The short Sendai virus leader region controls induction of programmed cell death

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RNA;

EID: 17644430475     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9063     Document Type: Article
Times cited : (30)

References (56)
  • 1
    • 0025932984 scopus 로고
    • Apoptosis; Mechanisms and roles in pathology
    • Arends M. J., Wyllie A. H. Apoptosis; mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32:1991;223-254.
    • (1991) Int. Rev. Exp. Pathol. , vol.32 , pp. 223-254
    • Arends, M.J.1    Wyllie, A.H.2
  • 2
    • 0026624714 scopus 로고
    • Gene expression of vesicular stomatitis virus genome RNA
    • Banerjee A. K., Barik S. Gene expression of vesicular stomatitis virus genome RNA. Virology. 188:1992;417-428.
    • (1992) Virology , vol.188 , pp. 417-428
    • Banerjee, A.K.1    Barik, S.2
  • 3
    • 0028274132 scopus 로고
    • An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/his sequence motifs
    • Birnbaum M. J., Clem R. J., Miller L. K. An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/his sequence motifs. J. Virol. 68:1994;2521-2528.
    • (1994) J. Virol. , vol.68 , pp. 2521-2528
    • Birnbaum, M.J.1    Clem, R.J.2    Miller, L.K.3
  • 4
    • 0029899289 scopus 로고    scopus 로고
    • The sendai paramyxovirus accessory c proteins inhibit viral genome amplification in a promoter-specific fashion
    • Cadd T., Garcin D., Tapparel C., Itoh M., Homma M., Roux L., Curran J., Kolakofsky D. The sendai paramyxovirus accessory c proteins inhibit viral genome amplification in a promoter-specific fashion. J. Virol. 70:1996;5067-5074.
    • (1996) J. Virol. , vol.70 , pp. 5067-5074
    • Cadd, T.1    Garcin, D.2    Tapparel, C.3    Itoh, M.4    Homma, M.5    Roux, L.6    Curran, J.7    Kolakofsky, D.8
  • 5
    • 0026804640 scopus 로고
    • Molecular cloning of natural paramyxovirus copy-back defective interfering RNAs and their expression from DNA
    • Calain P., Curran J., Kolakofsky D., Roux L. Molecular cloning of natural paramyxovirus copy-back defective interfering RNAs and their expression from DNA. Virology. 191:1992;62-71.
    • (1992) Virology , vol.191 , pp. 62-71
    • Calain, P.1    Curran, J.2    Kolakofsky, D.3    Roux, L.4
  • 6
    • 0028803832 scopus 로고
    • Functional characterisation of the genomic and antigenomic promoters of Sendai virus
    • Calain P., Roux L. Functional characterisation of the genomic and antigenomic promoters of Sendai virus. Virology. 212:1995;163-173.
    • (1995) Virology , vol.212 , pp. 163-173
    • Calain, P.1    Roux, L.2
  • 7
    • 0027999537 scopus 로고
    • Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death
    • Casciola-Rosen L. A., Miller D. K., Anhalt G. J., Rosen A. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem. 269:1994;30757-30760.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30757-30760
    • Casciola-Rosen, L.A.1    Miller, D.K.2    Anhalt, G.J.3    Rosen, A.4
  • 8
    • 0028787079 scopus 로고
    • Mutations in conserved domain I of the sendai virus L polymerase protein uncouple transcription and replication
    • Chandrika R., Horikami S. M., Smallwood S., Moyer S. A. Mutations in conserved domain I of the sendai virus L polymerase protein uncouple transcription and replication. Virology. 213:1995;352-363.
    • (1995) Virology , vol.213 , pp. 352-363
    • Chandrika, R.1    Horikami, S.M.2    Smallwood, S.3    Moyer, S.A.4
  • 9
    • 0026344133 scopus 로고
    • Prevention of apoptosis by a baculovirus gene during infection of insect cells
    • Clem R. J., Fechheimer M., Miller L. K. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science. 254:1991;1388-1390.
    • (1991) Science , vol.254 , pp. 1388-1390
    • Clem, R.J.1    Fechheimer, M.2    Miller, L.K.3
  • 10
    • 0027215907 scopus 로고
    • Apoptosis reduces both thein vitroin vivo
    • Clem R. J., Miller L. K. Apoptosis reduces both thein vitroin vivo. J. Virol. 67:1993;3730-3738.
    • (1993) J. Virol. , vol.67 , pp. 3730-3738
    • Clem, R.J.1    Miller, L.K.2
  • 11
    • 0024427605 scopus 로고
    • Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins
    • Crone D., Keene J. D. Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins. J. Virol. 63:1989;4172-4180.
    • (1989) J. Virol. , vol.63 , pp. 4172-4180
    • Crone, D.1    Keene, J.D.2
  • 12
    • 0025783770 scopus 로고
    • The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing
    • Curran J., Boeck R., Kolakofsky D. The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing. EMBO J. 10:1991;3079-3089.
    • (1991) EMBO J. , vol.10 , pp. 3079-3089
    • Curran, J.1    Boeck, R.2    Kolakofsky, D.3
  • 13
    • 0027397837 scopus 로고
    • Molecular cloning and characterization of a Sendai virus internal deletion defective RNA
    • Engelhorn M., Stricker R., Roux L. Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. J. Gen. Virol. 74:1993;137-141.
    • (1993) J. Gen. Virol. , vol.74 , pp. 137-141
    • Engelhorn, M.1    Stricker, R.2    Roux, L.3
  • 14
    • 0000233999 scopus 로고
    • Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst T. R., Niles E. G., Studier F. W., Moss B. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA. 83:1986;8122-8126.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3    Moss, B.4
  • 16
    • 0029562067 scopus 로고
    • A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: Generation of a novel copy-back nondefective interfering virus
    • Garcin D., Pelet T., Calain P., Roux L., Curran J., Kolakofsky D. A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy-back nondefective interfering virus. EMBO J. 14:1995;6087-6094.
    • (1995) EMBO J. , vol.14 , pp. 6087-6094
    • Garcin, D.1    Pelet, T.2    Calain, P.3    Roux, L.4    Curran, J.5    Kolakofsky, D.6
  • 17
    • 0030219960 scopus 로고    scopus 로고
    • Viral inhibition of apoptosis
    • Gillet G., Brun G. Viral inhibition of apoptosis. Trends Microbiol. 4:1996;312-316.
    • (1996) Trends Microbiol. , vol.4 , pp. 312-316
    • Gillet, G.1    Brun, G.2
  • 18
    • 0027260656 scopus 로고
    • Epstein-Barr virus-coded BHRF1 protein, a viral homologue of bcl-2, protects human B cells from programmed cell death
    • Henderson S., Huen D., Rowe M., Dawson C., Johnson G., Rickenson A. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of bcl-2, protects human B cells from programmed cell death. Proc. Natl. Acad. Sci. USA. 90:1993;8479-8483.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8479-8483
    • Henderson, S.1    Huen, D.2    Rowe, M.3    Dawson, C.4    Johnson, G.5    Rickenson, A.6
  • 19
    • 0027397409 scopus 로고
    • Identification and characterization of the p35 gene ofBombyx mori
    • Kamita S. G., Majima K., Maeda S. Identification and characterization of the p35 gene ofBombyx mori. J. Virol. 67:1993;455-463.
    • (1993) J. Virol. , vol.67 , pp. 455-463
    • Kamita, S.G.1    Majima, K.2    Maeda, S.3
  • 20
    • 0022214683 scopus 로고
    • Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression
    • Keene J. D. Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression. Microbiol. Sci. 2:1985;152.
    • (1985) Microbiol. Sci. , vol.2 , pp. 152
    • Keene, J.D.1
  • 21
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J. F. R, Wyllie A. H., Currie A. R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 22
    • 0029144682 scopus 로고
    • Induction of apoptotic DNA fragmentation by the infection of vesicular stomatitis virus
    • Koyama A. H. Induction of apoptotic DNA fragmentation by the infection of vesicular stomatitis virus. Virus Res. 37:1995;285-290.
    • (1995) Virus Res. , vol.37 , pp. 285-290
    • Koyama, A.H.1
  • 23
    • 0020559403 scopus 로고
    • The leader RNA of VSV is bound by a cellular protein reactive with anti-La lupus antibodies
    • Kurilla M. G., Keene J. D. The leader RNA of VSV is bound by a cellular protein reactive with anti-La lupus antibodies. Cell. 34:1983;837-845.
    • (1983) Cell , vol.34 , pp. 837-845
    • Kurilla, M.G.1    Keene, J.D.2
  • 25
    • 0027437541 scopus 로고
    • Nuclear events of apoptosis in vitro in cell-free mitotic extracts: A model system for analysis of the active phase of apoptosis
    • Lazebnik Y. A., Cole S., Cooke C. A., Nelson W. G., Earnshaw W. C. Nuclear events of apoptosis in vitro in cell-free mitotic extracts: A model system for analysis of the active phase of apoptosis. J. Cell Biol. 123:1993;7-22.
    • (1993) J. Cell Biol. , vol.123 , pp. 7-22
    • Lazebnik, Y.A.1    Cole, S.2    Cooke, C.A.3    Nelson, W.G.4    Earnshaw, W.C.5
  • 26
    • 0019815485 scopus 로고
    • The origin of defective-interfering particles of the negative-strand RNA viruses
    • Lazzarini R. A., Keene J. D., Schubert M. The origin of defective-interfering particles of the negative-strand RNA viruses. Cell. 26:1981;145-154.
    • (1981) Cell , vol.26 , pp. 145-154
    • Lazzarini, R.A.1    Keene, J.D.2    Schubert, M.3
  • 27
    • 0028290902 scopus 로고
    • The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis
    • Lee S. B., Esteban M. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology. 199:1994;491-496.
    • (1994) Virology , vol.199 , pp. 491-496
    • Lee, S.B.1    Esteban, M.2
  • 28
    • 0343812093 scopus 로고    scopus 로고
    • The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases
    • Lee S. B., Rodriguez D, Rodriguez J. R., Esteban M. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases. Virology. 231:1997;81-88.
    • (1997) Virology , vol.231 , pp. 81-88
    • Lee, S.B.1    Rodriguez, D.2    Rodriguez, J.R.3    Esteban, M.4
  • 29
    • 0017718997 scopus 로고
    • Further characterization of Sendai virus DI-RNAs: A model for their generation
    • Leppert M., Kort L., Kolakofsky D. Further characterization of Sendai virus DI-RNAs: A model for their generation. Cell. 12:1977;539-552.
    • (1977) Cell , vol.12 , pp. 539-552
    • Leppert, M.1    Kort, L.2    Kolakofsky, D.3
  • 30
    • 0018664147 scopus 로고
    • Plus and minus strand leader RNAs in negative strand virus-infected cells
    • Leppert M., Rittenhouse L., Perrault J., Summers D. F., Kolakofsky D. Plus and minus strand leader RNAs in negative strand virus-infected cells. Cell. 18:1979;735-747.
    • (1979) Cell , vol.18 , pp. 735-747
    • Leppert, M.1    Rittenhouse, L.2    Perrault, J.3    Summers, D.F.4    Kolakofsky, D.5
  • 32
    • 0028670387 scopus 로고
    • Signalling and chromatin fragmentation in thymocyte apoptosis
    • McConkey D. J., Nicotera P., Orrenius S. Signalling and chromatin fragmentation in thymocyte apoptosis. Immunol. Rev. 142:1994;343-363.
    • (1994) Immunol. Rev. , vol.142 , pp. 343-363
    • McConkey, D.J.1    Nicotera, P.2    Orrenius, S.3
  • 33
    • 0020035760 scopus 로고
    • The plus-strand leader RNA of VSV inhibits DNA dependent transcription of adenoviris and SV40 genes in a soluble whole cell extract
    • McGowan J. J., Emerson S. U., Wagner R. R. The plus-strand leader RNA of VSV inhibits DNA dependent transcription of adenoviris and SV40 genes in a soluble whole cell extract. Cell. 28:1982;325-333.
    • (1982) Cell , vol.28 , pp. 325-333
    • McGowan, J.J.1    Emerson, S.U.2    Wagner, R.R.3
  • 34
    • 0031984986 scopus 로고    scopus 로고
    • A functional antigenomic promoter for the paramyxovirus SV5 requires proper spacing between an essential internal segment and the 3′ terminus
    • Murphy S. K., Ito Y., Parks G. D. A functional antigenomic promoter for the paramyxovirus SV5 requires proper spacing between an essential internal segment and the 3′ terminus. J. Virol. 72:1998;10-19.
    • (1998) J. Virol. , vol.72 , pp. 10-19
    • Murphy, S.K.1    Ito, Y.2    Parks, G.D.3
  • 35
    • 0030588166 scopus 로고    scopus 로고
    • Partial characterization of a Sendai virus replication promoter and the rule of six
    • Pelet T., Delenda C., Gubbay O., Garcin D., Kolakofsky D. Partial characterization of a Sendai virus replication promoter and the rule of six. Virology. 224:1996;405-414.
    • (1996) Virology , vol.224 , pp. 405-414
    • Pelet, T.1    Delenda, C.2    Gubbay, O.3    Garcin, D.4    Kolakofsky, D.5
  • 36
    • 0019343549 scopus 로고
    • Origin and replication of defective interfering particles
    • Perrault J. Origin and replication of defective interfering particles. Curr. Top. Microbiol. Immunol. 93:1981;151-207.
    • (1981) Curr. Top. Microbiol. Immunol. , vol.93 , pp. 151-207
    • Perrault, J.1
  • 37
    • 0026504147 scopus 로고
    • Social controls on cell survival and death: An extreme view
    • Raff M. C. Social controls on cell survival and death: An extreme view. Nature. 356:1992;397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 39
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    • Rao L., Debbas M., Sabbatini P., Hockenberg D., Korsmeyer S., White E. The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA. 89:1992;7742-7746.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7742-7746
    • Rao, L.1    Debbas, M.2    Sabbatini, P.3    Hockenberg, D.4    Korsmeyer, S.5    White, E.6
  • 40
    • 0026728952 scopus 로고
    • Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1b converting enzyme
    • Ray C. A., Black R. A., Kronheim S. R., Greenstreet T. A., Sleath P. R., Salvesen G. S., Pickup D. J. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1b converting enzyme. Cell. 69:1992;597-604.
    • (1992) Cell , vol.69 , pp. 597-604
    • Ray, C.A.1    Black, R.A.2    Kronheim, S.R.3    Greenstreet, T.A.4    Sleath, P.R.5    Salvesen, G.S.6    Pickup, D.J.7
  • 41
    • 0003359608 scopus 로고
    • Deletion mutants of paramyxoviruses
    • New York: Plenum. p. 275-295
    • Re G. G. Deletion mutants of paramyxoviruses. The Paramyxoviruses. 1990;Plenum, New York. p. 275-295.
    • (1990) The Paramyxoviruses
    • Re, G.G.1
  • 42
    • 0018383037 scopus 로고
    • Role of defective interfering particles of Sendai virus in persistent infections
    • Roux L., Holland J. J. Role of defective interfering particles of Sendai virus in persistent infections. Virology. 93:1979;91-103.
    • (1979) Virology , vol.93 , pp. 91-103
    • Roux, L.1    Holland, J.J.2
  • 43
    • 0019463812 scopus 로고
    • Establishment of Sendai virus persistent infection: Biochemical analysis of the early phase of a standard plus defective interfering virus infection of BHK cells
    • Roux L., Waldvogel F. Establishment of Sendai virus persistent infection: Biochemical analysis of the early phase of a standard plus defective interfering virus infection of BHK cells. Virology. 112:1981;400-410.
    • (1981) Virology , vol.112 , pp. 400-410
    • Roux, L.1    Waldvogel, F.2
  • 44
    • 0028040449 scopus 로고
    • Infectious rabies viruses from cloned cDNA
    • Schnell M. J., Mebatsion T., Conzelmann K. K. Infectious rabies viruses from cloned cDNA. EMBO J. 13:1994;4195-4203.
    • (1994) EMBO J. , vol.13 , pp. 4195-4203
    • Schnell, M.J.1    Mebatsion, T.2    Conzelmann, K.K.3
  • 46
    • 0030297279 scopus 로고    scopus 로고
    • The efficiency of Sendai virus genome replication: The importance of the RNA primary sequence independent of terminal complementarity
    • Tapparel C., Roux L. The efficiency of Sendai virus genome replication: The importance of the RNA primary sequence independent of terminal complementarity. Virology. 225:1996;163-171.
    • (1996) Virology , vol.225 , pp. 163-171
    • Tapparel, C.1    Roux, L.2
  • 47
    • 0031041172 scopus 로고    scopus 로고
    • Regulation of apoptosis by viral gene products
    • Teodoro J. G., Branton P. E. Regulation of apoptosis by viral gene products. J. Virol. 71:1997;1739-1746.
    • (1997) J. Virol. , vol.71 , pp. 1739-1746
    • Teodoro, J.G.1    Branton, P.E.2
  • 49
    • 0029945204 scopus 로고    scopus 로고
    • A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture
    • Van Engeland M., Ramaekers F. C., Schutte B., Reutelingsperger C. P. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry. 24:1996;131-139.
    • (1996) Cytometry , vol.24 , pp. 131-139
    • Van Engeland, M.1    Ramaekers, F.C.2    Schutte, B.3    Reutelingsperger, C.P.4
  • 50
    • 0025666859 scopus 로고
    • Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases
    • Van Venrooij W. J., Hoet R., Castrop J., Hageman B., Mattaj I. W., van de Putte L. B. Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J. Clin. Invest. 86:1990;2154-2160.
    • (1990) J. Clin. Invest. , vol.86 , pp. 2154-2160
    • Van Venrooij, W.J.1    Hoet, R.2    Castrop, J.3    Hageman, B.4    Mattaj, I.W.5    Van De Putte, L.B.6
  • 51
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
    • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods. 184:1995;39-51.
    • (1995) J. Immunol. Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 52
    • 0024584245 scopus 로고
    • Modified model for the switch from Sendai virus transcription to replication
    • Vidal S., Kolakofsky D. Modified model for the switch from Sendai virus transcription to replication. J. Virol. 63:1989;1951-1958.
    • (1989) J. Virol. , vol.63 , pp. 1951-1958
    • Vidal, S.1    Kolakofsky, D.2
  • 53
    • 0018414725 scopus 로고
    • Transcription of vesicular stomatitis virus is required to shut off cellular RNA synthesis
    • Weck P. K., Wagner R. R. Transcription of vesicular stomatitis virus is required to shut off cellular RNA synthesis. J. Virol. 30:1979;410-413.
    • (1979) J. Virol. , vol.30 , pp. 410-413
    • Weck, P.K.1    Wagner, R.R.2
  • 54
    • 0018743803 scopus 로고
    • Use of UV irradiation to identify the genetic information of VSV responsible for shutting off cellular RNA synthesis
    • Weck P. K., Carroll A. R., Shattuck D. M., Wagner R. R. Use of UV irradiation to identify the genetic information of VSV responsible for shutting off cellular RNA synthesis. J. Virol. 30:1979;746-753.
    • (1979) J. Virol. , vol.30 , pp. 746-753
    • Weck, P.K.1    Carroll, A.R.2    Shattuck, D.M.3    Wagner, R.R.4
  • 55
    • 0026773471 scopus 로고
    • The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor a
    • White E., Sabbatini P., Debbas M., Wold W. S. M., Kusher D. I., Gooding L. R. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor a. Mol. Cell. Biol. 12:1992;2570-2580.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2570-2580
    • White, E.1    Sabbatini, P.2    Debbas, M.3    Wold, W.S.M.4    Kusher, D.I.5    Gooding, L.R.6
  • 56


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