The various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection

Journal of Virology

Volumn 72, Issue 7, 1998, Pages 5984-5993

  Latorre, Patrizia ^a   Cadd, Tamarra ^a,e   Itoh, Masae ^b,c   Curran, Joseph ^a   Kolakofsky, Daniel ^a,d  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b KOBE UNIVERSITY   (Japan)

^c OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C; VIRUS RNA;

ARTICLE; CELL CULTURE; MOUSE; NONHUMAN; PARAMYXOVIRUS; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SYNTHESIS; SENDAI VIRUS; START CODON; VIRUS INFECTION; VIRUS MUTATION; VIRUS VIRULENCE;

EID: 0031779698     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.7.5984-5993.1998     Document Type: Article

References (40)

1. Alkhatib, G., B. Massie, and D. J. Briedis. 1988. Expression of bicistronic measles virus P/C mRNA by using hybrid adenoviruses: levels of C protein synthesized in vivo are unaffected by the presence or absence of the upstream P initiator colon. J. Virol. 62:4059-4069.
2. Barr, J., P. Chambers, P. Harriott, C. R. Pringle, and A. J. Easton. 1994. Sequence of the phosphoprotein gene of pneumonia virus of mice: expression of multiple proteins from two overlapping reading frames. J. Virol. 68: 5330-5334.
3. Bellini, W. J., G. Englund, S. Rozenblatt, H. Arnheiter, and C. D. Richardson. 1985. Measles virus P gene codes for two proteins. J. Virol. 53:908-919.
4. Billeter, M. A., R. Cattaneo, P. Spielhofer, K. Kaelin, M. Huber, A. Schmid, K. Baczko, and V. ter Meulen. 1994. Generation and properties of measles virus mutations typically associated with subacute sclerosing panencephalitis. Ann. N. Y. Acad. Sci. 724:367-377.
5. Boeck, R., and D. Kolakofsky. 1994. Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis. EMBO J. 13:3608-3617.
6. Cadd, T., D. Garcin, C. Tapparel, M. Itoh, M. Homma, L. Roux, J. Curran, and D. Kolakofsky. 1996. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion. J. Virol. 70: 5067-5074.
7. Curran, J., P. Latorre, and D. Kolakofsky. 1998. Translational gymnastics on the Sendai virus P/C mRNA. Semin. Virol. 8:351-357.
8. Curran, J., J.-B. Marq, and D. Kolakofsky. 1992. The Sendai virus nonstructural C proteins specifically inhibit viral mRNA synthesis. Virology 189: 647-656.
9. Delenda, C., S. Hausmann, D. Garcin, and D. Kolakofsky. 1997. Normal cellular replication of Sendai virus without trans-frame nonstructural V protein. Virology 228:55-62.
10. Delenda, C., G. Taylor, S. Hausmann, D. Garcin, and D. Kolakofsky. 1998. Sendai viruses with altered P, V, and W protein expression. Virology 242: 327-337.
11. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83: 8122-8126.
12. Garcin, D., T. Pelet, P. Calain, L. Roux, J. Curran, and D. Kolakofsky. 1995. A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy-back nondefective interfering virus. EMBO J. 14:6087-6094.
13. Garcin, D., M. Itoh, and D. Kolakofsky. 1997. A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not virus growth in cell culture. Virology 238:424-431.
14. Giorgi, C., B. M. Blumberg, and D. Kolakofsky. 1983. Sendai virus contains overlapping genes expressed from a single mRNA. Cell 35:829-836.
15. Grunert, S., and R. J. Jackson. 1994. The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons. EMBO J. 13:3618-3630.
16. Höglund, S., A. Ohagen, K. Lawrence, and D. Gabudzda. 1994. Role of vif during packing of the core of HIV-1. Virology 201:349-355.
17. Horikami, S. M., R. E. Hector, S. Smallwood, and S. A. Moyer. 1997. The Sendai virus C protein binds the L polymerase protein to inhibit viral RNA synthesis. Virology 235:261-270.
18. Itoh, M., Y. Isegawa, H. Hotta, and M. Homma. 1997. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. J. Gen. Virol. 78: 3207-3215.
19. Kato, A., K. Kiyotani, Y. Sakai, T. Yoshida, and Y. Nagai. 1997. The paramyxovirus Sendai virus V protein encodes a luxury function required for viral pathogenesis. EMBO J. 16:678-587.
20. Kiyotani, K., S. Takao, T. Sakaguchi, and T. Yoshida. 1990. Immediate protection of mice from lethal Sendai virus infection by a temperature sensitive mutant (HVJpi) possessing homologous interfering capacity. Virology 177:65-74.
21. Kretzschmar, E., R. Peluso, M. J. Schnell, M. A. Whitt, and J. K. Rose. 1996. Normal replication of vesicular stomatitis virus without C proteins. Virology 216:309-316.
22. Kurotani, A., K. Kiyotani, A. Kato, T. Shioda, Y. Saki, K. Mizumoto, T. Yoshida, and Y. Nagai. 1998. The paramyxovirus, Sendai virus, C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Genes Cells 3:111-124.
23. Lamb, R. A., and R. G. Paterson. 1991. The nonstructural proteins of paramyxoviruses, p. 181-210. In D. W. Kingsbury (ed.), The paramyxoviruses. Plenum Press, New York, N.Y.
24. Latorre, P., D. Kolakofsky, and J. Curran. The Sendai virus Y proteins are initiated by a ribosomal shunt. Submitted for publication.
25. Murphy, F. A., C. M. Fauquet, and D. H. L. Bishop. 1994. Sixth report of the international committee on taxonomy of viruses. Arch. Virol. Suppl. 10: 268-274.
26. Orvell, C., and M. Grandien. 1982. The effects of monoclonal antibodies on biological activities of structural proteins of Sendai virus. J. Immunol. 129: 2779-2787.
27. Pelet, T., C. Delenda, O. Gubbay, D. Garcin, and D. Kolakofsky. 1996. Partial characterization of a Sendai virus replication promoter and the rule of six. Virology 224:405-414.
28. Portner, A., K. C. Gupta, J. M. Seyer, E. H. Beachey, and D. W. Kingsbury. 1986/87. Localization and characterization of Sendai virus nonstructural C and C′ proteins by antibodies against synthetic peptides. Virus Res. 6:109-121.
29. Radecke, F., and M. A. Billeter. 1996. The nonstructural C protein is not essential for multiplication of Edmunston B strain measles virus in cultured cells. Virology 217:418-421.
30. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 23:493-497.
31. Spiropoulou, C. F., and S. T. Nichol. 1993. A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus. J. Virol. 67:3103-3110.
32. Tapparel, C., S. Hausmann, T. Pelet, J. Curran, D. Kolakofsky, and L. Roux. 1997. Inhibition of Sendai virus genome replication due to promoter-increased selectivity: a possible role for the accessory C proteins. J. Virol. 71: 9588-9599.
33. Thomas, S. M., R. A. Lamb, and R. G. Paterson. 1988. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54:891-902.
34. Trono, D. 1995. HIV accessory proteins: leading roles for the supporting cast. Cell 82:189-192.
35. Vidal, S., J. Curran, and D. Kolakofsky. 1990. Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity. J. Virol. 64:239-246.
36. Vilcek, J., and G. C. Sen. 1996. Interferons and other cytokines, p. 375-399. In B. N. Fields, D. N. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
37. von Schwedler, U., J. Song, C. Aiken, and D. Trono. 1993. vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol. 67:4945-4955.
38. Wang, X.-L., M. Itoh, H. Hotta, and M. Homma. 1994. A protease activation mutant, MVCES1, as a safe and potent live vaccine derived from currently prevailing Sendai virus. Virology 68:3369-3373.
39. Yamada, H., S. Hayata, T. Omata-Yamada, H. Taira, K. Mizumoto, and K. Iwasaki. 1990. Association of the Sendai virus C protein with nucleocapsids. Arch. Virol. 113:245-253.
40. Yueh, A., and R. J. Schneider. 1996. Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. Genes Dev. 10: 1557-1567.