Damage control - A possible non-proteolytic role for ubiquitin in limiting neurodegeneration

Neuropathology and Applied Neurobiology

Volumn 27, Issue 2, 2001, Pages 89-94

  Gray, D A ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

Inclusions; Proteasome; Sequestration; Ubiquitin

Indexed keywords

PROTEASOME; UBIQUITIN;

ARTICLE; CELL INCLUSION; DEGENERATIVE DISEASE; GENE MUTATION; HUMAN; NERVE DEGENERATION; OXIDATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN INTERACTION;

CYSTEINE ENDOPEPTIDASES; HUMANS; MULTIENZYME COMPLEXES; NERVE DEGENERATION; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINS;

EID: 0034951251     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2001.00321.x     Document Type: Article

References (40)

1. Protein expression using ubiquitin fusion and cleavage
2. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product - Huntingtin
3. Ubiquitin-mediated proteolysis: Biological regulation via destruction
4. A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes
5. Neuronal growth and death: Order and disorder in the axoplasm
6. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
7. Identification of genes that modify ataxin-1-induced neurodegeneration
8. Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease
9. Accumulation of ubiquitinated proteins in mouse neuronal cells induced by oxidative stress
10. Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells
11. The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis
12. A regulatory link between ER-associated protein degradation and the unfolded-protein response
13. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell haemoglobin by (the 19 S) proteasome
14. Cell cycle. The only way out of mitosis
15. Degradation of oxidized proteins in mammalian cells
16. Quality control in the secretory pathway
17. Oxidative stress induces amyloid-like aggregate formation of NACP/alpha- synuclein in vitro
18. The ubiquitin system
19. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin protein ligase activity
20. The demonstration of new human brain-specific proteins by high-resolution two-dimensional polyacrylamide gel electrophoresis
21. Resistance to cadmium mediated by ubiquitin-dependent proteolysis
22. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
23. Structural neurology: Are seeds at the root of neuronal degeneration?
24. Ubiquitin in neurodegenerative diseases
25. Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases
26. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
27. Polyubiquitin chains
28. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity
29. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice
30. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
31. Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells
32. The unfolded protein response: An intracellular signalling pathway with many surprising features
33. Aggregation of ubiquitin and a mutant ALS-linked SOD1 protein correlate with disease progression and fragmentation of the Golgi apparatus
34. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
35. Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin
36. The 26S proteasome: A molecular machine designed for controlled proteolysis
37. PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival
38. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes
39. Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
40. Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a