Just how does the cII selection system work in Muta™Mouse?

Environmental and Molecular Mutagenesis

Volumn 37, Issue 4, 2001, Pages 290-296

  Swiger, Roy R ^a,b  

^a YORK UNIVERSITY   (Canada)

^b MIDWEST RESEARCH INSTITUTE   (United States)

Author keywords

Bacteriophage; Lambdo; Lyric; Lysogeny; Mechanism; Mutagenesis

Indexed keywords

VIRUS PROTEIN;

ARTICLE; BACTERIOPHAGE LAMBDA; CELL INTERACTION; GENETIC RECOMBINATION; GENOTYPE; LYSOGENIZATION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; TRANSGENE;

ANIMALS; BACTERIOPHAGES; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; GENETIC TECHNIQUES; LYSOGENY; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TEMPERATURE; VIRAL PROTEINS;

BACTERIA (MICROORGANISMS); RODENTIA;

EID: 0034946878     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.1035     Document Type: Article

References (46)

1. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
2. Identification of polypeptides encoded by an Escherichia coli locus (hflA) that governs the lysis-lysogeny decision of bacteriophage λ
3. hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein
4. An analysis of the processes of infection and induction of E. coli mutant hlf-1 by bacteriophage lambda
5. Cytogenetic mapping of lambda gt10 lacZ sequences in the transgenic mouse strain 40.6 (Muta™Mouse)
6. ENU-induced mutagenesis at a single A: T base pair in transgenic mice containing phi X174
7. Cleavage of the cII protein of phage λ by purified HflA protease: Control of switch between lysis and lysogeny
8. Measurement of gene mutation in vivo using Muta™ Mouse and positive selection for LacZ phage
9. The use of shuttle vectors for mutation analysis in transgenic mice and rats
10. A selective system for lacZ-phage using galactose-sensitive E. coli host
11. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
12. Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of Big Blue® mice
13. The HflB protease of Escherichia coli degrades its inhibitor λ CIII
14. Bacteriophage λ proteia cII binds promoters on the opposite face of the DNA helix from RNA polymerase
15. Control of phage lambda development by stability and synthesis of cII protein: Role of the viral cIII and host hflA, himA and himD genes
16. Constructing and screening cDNA libraries in λgt10 and λgt11
17. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage λ transgene target
18. Interaction between DNA-bound repressors govern regulation by λ phage repressor
19. Mutations in a temperate bacteriophage affecting its ability to lysogenize
20. Host regulation of lysogenic decision in bacteriophage λ: Transmembrane modulation of FtsH (HflB), the cII degrading protease by HflKC (HflA)
21. Development of a short-term, in vivo mutagenesis assay: The effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice
22. Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector
23. Tissue specificity of spontaneous point mutations in lambda supF transgenic mice
24. Induction de la production de bacteriophages chez une bacterie lysogene
25. A comparative study of in vivo mutation assays: Analysis of hprt, lacI, and cII/cI as mutational targets for N-nitroso-N-methylurea and benzo-[a]pyrene in Big Blue™ mice
26. Lamboid phages that simplify the recovery of in vitro recombinants
27. The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains protease-like domain
28. - and 6-thioguanine selection
29. Stability of CII is a key element in the cold stress response of bacteriophage λ infection
30. Dietary restriction during murine development provides protection against MNU-induced mutations
31. Purified λ regulatory protein cII positively activates promoters for lysogenic development
32. Proteolysis of bacteriophage λ CII by Escherichia coli FtsH (HflB)
33. Characterization of a conserved α-helical, cloiled-coil motif at the C-terminal domain of the ATP-dependent FtsH(HflB) protease of Escherichia coli
34. Interpretation of mutational spectra from different genes: Analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue® rats
35. The lacZ in Muta™Mouse maps to chromosome 3
36. The cII locus in the Muta™Mouse System
37. Drastically decreased transcription from CII-activated promoters is responsible for impaired lysogenization of the Escherichia coli rpoA341 mutant by bacteriophage λ
38. Specific mutations induced by triplex-forming oligonucleotides in mice
39. Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue® Rat2 embryonic fibroblasts
40. Detection of mutations in transgenic fish crowing a bacteriophage lambda cII transgene target
41. Comparison of mutant frequencies at the transgenic lambda lacI and cII/cI loci in control and ENU-treated Big Blue® mice