Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: Relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity

Journal of Molecular Medicine

Volumn 79, Issue 5-6, 2001, Pages 294-299

  Simó, Josep M ^a   Joven, Jorge ^a   Vilella, Elisabet ^a,b   Ribas, Montserrat ^a   Figuera, Lídia ^a,b   Virgos, Carmen ^a,b   Sundaram, Indirani M ^c   Hoover Plow, Jane ^c  

^a HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^b IISPV   (Spain)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Apoprotein(a); Kringle IV 10; Lipoprotein(a); Lysine binding site activity; Mutation; Polymorphism

Indexed keywords

APOLIPOPROTEIN A; DNA; LIPOPROTEIN A; LYSINE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME BINDING; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HUMAN; KRINGLE DOMAIN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE;

EID: 0034945234     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090100203     Document Type: Article

References (32)

1. Lipoprotein(a) in health and disease
2. Kringle-dependent structural and functional polymorphism of apolipoprotein(a)
3. The apolipoprotein(a) gene resides in human chromosome 6q26-q27, in close proximity to the homologous gene for plasminogen
4. Molecular basis of apolipoprotein(a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis
5. The mysteries of lipoprotein(a)
6. Lp(a) glycoprotein phenotypes: Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma
7. The cell biology of the plasminogen system
8. Comparative binding and degradation of lipoprotein(a) and low density lipoprotein by human monocyte derived macrophages
9. Interaction of Lp(a) with plasminogen binding sites on cells
10. Interaction of lipoprotein(a) with the extracellular matrix
11. The binding of human recombinant apolipoprotein(a) and plasminogen to fibrin surfaces
12. Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice
13. A quantitative immunoassay for the lysine-binding function of Lipoprotein(a). Application to recombinant apo(a) and lipoprotein(a) in plasma
14. Rhesus monkey lipoprotein(a) binds to lysine sepharose and U937 monocytoid cells less efficiently than human lipoprotein(a). Evidence for the dominant role of kringle 4 (37)
15. A single point mutation (Trp72 Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a)
16. Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): An Asp57? Asn mutation in kringle IV-10 is associated with poor fibrin binding
17. The apolipoprotein(a) kringle IV repeats which differ from the major repeats kringle are present in variably-sized isoforms
18. Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the apolipoprotein(a) size polymorphism
19. Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringle 32-36 of human apolipoprotein(a)
20. Lipoprotein(a) and the significance of the association between platelet glycoprotein IIIa polymorphisms and the risk of premature myocardial infarction
21. Nomenclature and criteria for diagnosis of ischemic heart disease
22. Automated measurement of lipoprotein(a) by immunoturbidimetric analysis
23. Polymorphic forms of human apolipoprotein(a): Inheritance and relationship of their molecular weights to plasma levels of lipoprotein(a)
24. Amplification of human apo(a) kringle IV-37 from blood lymphocyte DNA
25. Optimization of the single-strand conformation polymorphism (SSCP) technique for detection of point mutations
26. Evaluation of a homogeneous assay for high density lipoprotein cholesterol: Limitations in patients with cardiovascular, renal and hepatic disorders
27. Testing for linkage disequilibrium in genotypic data using the EM algorithm
28. Lipoprotein(a) interactions with lipid and non-lipid risk factors in patients with early onset coronary artery disease. Results from the NHLBI Family Heart Study
29. The functional and clinical significance of the Met toThr substitution in kringle IV type 10 of apolipoprotein(a)
30. Polymorphism in apolipoprotein(a) kringle IV 37 (Met/Thr): Frequency in a London population and its association with coronary artery disease
31. Myocardial infarction and coronary deaths in the World Health Organization MONICA project
32. Sequence polymorphisms in the apolipoprotein(a) gene. Evidence for dissociation between apolipoprotein(a) size and plasma lipoprotein(a) levels