Polymorphism in apolipoprotein(a) kringle IV 37 (Met/Thr): Frequency in a London population and its association with coronary artery disease

Clinical Cardiology

Volumn 20, Issue 10, 1997, Pages 870-872

  Syrris, Petros ^a   Schwartzman, Raul ^a   Jeffery, Steve ^a   Kaski, Juan Carlos ^a   Carter, Nick ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Apolipoprotein(a); Coronary artery disease; Kringle IV 37; Polymorphism

Indexed keywords

APOLIPOPROTEIN A;

ADULT; AGED; ARTICLE; CORONARY ARTERY DISEASE; CORONARY RISK; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; KRINGLE DOMAIN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; RACE DIFFERENCE; UNITED KINGDOM;

EID: 0030822548     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.4960201014     Document Type: Article

References (6)

1. Miles LA, Fless GM, Levin EG, Scanu AM, Plow EF: A potential basis for the thrombotic risks associated with lipoprotein(a). Nature 1989;339:301-303
2. McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM: cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 1987;300: 132-137
3. Scanu AM, Pfaffinger D, Lee JC, Hinman J: A single point mutation (Trp72→Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a). Biochim Biophys Acta 1994;1227: 41-45
4. Scanu AM, Pfaffinger D, Klezovitch O, Edelstein C: Genetically-determined polymorphism of kringle 4-37 of human apolipoprotein(a) (abstr). Circulation 1994;I-623
5. Kraft HG, Haibach C, Lingenhel A, Brunner C, Trommsdorff M, Kronenberg F, Muller HJ, Utermann G: Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the apolipoprotein(a) size polymorphism. Hum Genet 1995;95:275-282
6. Pfaffinger D, McLean J, Scanu AM: Amplification of human Apo(a) kringle 4-37 from blood lymphocyte DNA. Biochim Biophys Acta 1993;1225:107-109