-
2
-
-
0015694748
-
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
9
-
-
0024343691
-
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl
-
(1989)
EMBO J
, vol.8
, pp. 449-456
-
-
Jackson, P.1
Baltimore, D.2
-
11
-
-
0034634597
-
c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology of 3 domain and by autophosphorylation at two distinct regulatory tyrosines
-
(2000)
J Biol Chem
, vol.275
, pp. 35631-35637
-
-
Brasher, B.B.1
Van Etten, R.A.2
-
12
-
-
0027536793
-
An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias
-
(1993)
EMBO J
, vol.12
, pp. 1533-1546
-
-
McWhirter, J.R.1
Wang, J.Y.2
-
14
-
-
0029879676
-
The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
-
(1996)
EMBO J
, vol.15
, pp. 1583-1595
-
-
Wen, S.T.1
Jackson, P.K.2
Van Etten, R.A.3
-
15
-
-
0024353722
-
The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
-
(1989)
Cell
, vol.58
, pp. 669-678
-
-
Van Etten, R.A.1
Jackson, P.2
Baltimore, D.3
-
19
-
-
0027429964
-
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-abl tyrosine kinase in the cell cycle
-
(1993)
Cell
, vol.75
, pp. 779-790
-
-
Welch, P.J.1
Wang, J.Y.2
-
20
-
-
0029093830
-
Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5542-5551
-
-
Welch, P.J.1
Wang, J.Y.2
-
35
-
-
0029816460
-
The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype
-
(1996)
Blood
, vol.88
, pp. 2375-2384
-
-
Melo, J.1
-
38
-
-
10144254429
-
Neutrophilic-chronic myeloid leukemia: A distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)
-
(1996)
Blood
, vol.88
, pp. 2410-2414
-
-
Pane, F.1
Frigeri, F.2
Sindona, M.3
-
45
-
-
0035014278
-
Recent advances in the molecular and cellular biology of CML: Lessons to be learned from the laboratory
-
In Press
-
(2001)
Br J Haematol
-
-
Holyoake, T.1
-
55
-
-
0032533620
-
BCR-ABL efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
-
(1998)
Blood
, vol.92
, pp. 3829-3840
-
-
Zhang, X.1
Ren, R.2
-
56
-
-
0032533257
-
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving a P210 bcr/abl-transduced bone marrow
-
(1998)
Blood
, vol.92
, pp. 3780-3792
-
-
Pear, W.S.1
Miller, J.P.2
Xu, L.3
-
63
-
-
0026458235
-
Tyrphostins: Tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction
-
(1992)
FASEB J
, vol.6
, pp. 3275-3282
-
-
Levitzki, A.1
-
65
-
-
0031752846
-
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta I integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukaemia hematopoietic progenitors
-
(1998)
Leukemia
, vol.12
, pp. 1708-1717
-
-
Bhatia, R.1
Munthe, H.A.2
Verfaillie, C.M.3
-
70
-
-
0026746308
-
Effect of herbimycin A, an antagonist of tyrosine kinase, on bcr/abl oncoprotein-associated cell proliferations: Abrogative effect on the transformation of murine hematopoietic cells by transfection of a retroviral vector expressing oncoprotein P210 bcr/abl and preferential inhibition on Ph-I-positive leukemia cell growth
-
(1992)
Blood
, vol.80
, pp. 1330-1338
-
-
Okabe, M.1
Uehara, Y.2
Miyagishima, T.3
-
73
-
-
10244255276
-
Selection of myeloid progenitors lacking BCR-ABL mRNA in chronic myelogenous leukemia patients after in-vitro treatment with the tyrosine kinase inhibitor genistein
-
(1996)
Blood
, vol.88
, pp. 3091-3100
-
-
Carlo-Stella, C.1
Dotti, G.2
Mangoni, L.3
-
79
-
-
0024383718
-
Platelet-derived growth factor
-
(1989)
Lancet
, vol.1
, pp. 1179-1182
-
-
Ross, R.1
-
85
-
-
0034689031
-
Blockade of the BCR-ABL kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of BCL-xL
-
(2000)
J Exp Med
, vol.191
, pp. 977-984
-
-
Horita, M.1
Andreu, E.J.2
Benito, A.3
-
87
-
-
0029131231
-
BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents
-
(1995)
Blood
, vol.86
, pp. 1148-1158
-
-
Bedi, A.1
Barber, J.2
Bedi, G.3
-
88
-
-
0034665903
-
CGP57148B (ST1571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs
-
(2000)
Blood
, vol.96
, pp. 2246-2253
-
-
Fang, G.1
Kim, C.N.2
Perkins, C.L.3
-
91
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
106
-
-
0001338423
-
Phase II study of ST1571, a tyrosine kinase inhibitor, in patients with resistant or refractory Philadelphia chromosome-positive chronic myeloid leukemia
-
Abstr 2022
-
(2000)
Blood
, vol.96
-
-
Kanterjian, H.1
Sawyers, C.L.2
Hochhaus, A.3
-
107
-
-
0001566710
-
A Phase II study of ST1571 in adult patients with Philadelphia chromosome positive chronic myeloid leukemia in accelerated phase
-
Abstr 2021
-
(2000)
Blood
, vol.96
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
109
-
-
0000348652
-
A Phase II study to determine the safety and anti-leukaemic effects of ST1571 in adult patients with Philadelphia chromosome positive acute leukemias
-
Abstr 3580
-
(2000)
Blood
, vol.96
-
-
Ottmann, O.G.1
Sawyers, C.L.2
Druker, B.J.3
-
110
-
-
85112374881
-
Value of interphase fluorescent in-situ hybridisation (iFISH) studies in monitoring response to ST1571 therapy in patients with Philadelphia chromosome positive chronic myelogenous leukemia
-
Abstr 4833
-
(2000)
Blood
, vol.96
-
-
Kanterjian, H.1
O'Brien, S.2
Hayes, K.J.3
-
111
-
-
0004622138
-
PCR-negative molecular remissions in chronic-accelerated-, and blast crisis-phase CML patients treated with ST1571, an ABL-specific kinase inhibitor
-
Abstr 2026
-
(2000)
Blood
, vol.96
-
-
Shah, N.P.1
Snyder, D.S.2
Nicoll, J.M.3
-
113
-
-
0034210577
-
Mechanism of resistance to the ABL tyrosine kinase inhibitor ST1571 in BCR/ABL -transformed hematopoietic cell lines
-
(2000)
Blood
, vol.95
, pp. 3498-3505
-
-
Weisberg, E.1
Griffin, J.D.2
-
114
-
-
0034254368
-
Selection and characterisation of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST1571: Diverse mechanisms of resistance
-
(2000)
Blood
, vol.96
, pp. 1070-1079
-
-
Mahon, F.X.1
Deininger, M.W.2
Schultheis, B.3
-
115
-
-
0001338426
-
Relapse in Ph+ leukemia patients treated with an Abl-specific kinase inhibitor is associated with reactivation of Bcr-Abl
-
Abstr 2024
-
(2000)
Blood
, vol.96
-
-
Gorre, M.E.1
Banks, K.2
Hsu, N.C.3
-
116
-
-
0002342285
-
BCR/ABL gene amplification: A possible mechanism of drug resistance in patients treated with an abl-specific kinase inhibitor
-
Abstr 1486
-
(2000)
Blood
, vol.96
-
-
Mohammed, M.1
Shin, S.2
Deng, S.3
-
122
-
-
0035313251
-
In vitro cytotoxic effects of a tyrosine kinase inhibitor ST1571 in combination with commonly used antileukemic agents
-
(2001)
Blood
, vol.97
, pp. 1999-2007
-
-
Kano, Y.1
Akutsu, Y.2
Tsunoda, S.3
-
124
-
-
0035282901
-
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
-
(2001)
Blood
, vol.97
, pp. 1404-1412
-
-
Peters, D.G.1
Hoover, R.R.2
Gerlach, M.J.3
|