Calmodulin protects cells from death under normal growth conditions and mitogenic starvation but plays a mediating role in cell death upon B-cell receptor stimulation

Immunology

Volumn 103, Issue 3, 2001, Pages 332-342

  Schmalzigaug, Robert ^a   Ye, Qunrui ^b   Berchtold, Martin W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM ION; CALMODULIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE; CELL DEATH; CELL GROWTH; CELL PROTECTION; CONTROLLED STUDY; LYMPHOCYTE ACTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STARVATION;

ANIMALS; APOPTOSIS; CALCIUM; CALMODULIN; CELL CYCLE; CELL DIVISION; CHICKENS; GENE DELETION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034937572     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01259.x     Document Type: Article

References (83)

1. Calmodulin-binding domains: Just two faced or multi-faceted?
2. Isolation of the yeast calmodulin gene: Calmodulin is an essential protein
3. Analysis and in vivo disruption of the gene coding for calmodulin in Schizosaccharomyces pombe
4. Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans
5. Spontaneous avoidance behavior in Drosophila null for calmodulin expression
6. Calmodulin activation of target enzymes. Consequences of deletions in the central helix
7. Role of domain 3 of calmodulin in activation of calmodulin-stimulated phosphodiesterase and smooth muscle myosin light chain kinase
8. Localization of unique functional determinants in the calmodulin lobes to individual EF hands
9. The fourth EF-hand of calmodulin and its helix-loop-helix components: Impact on calcium binding and enzyme activation
10. Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases
11. Activation of calcineurin and smooth muscle myosin light chain kinase by Met-to-Leu mutants of calmodulin
12. Diverse essential functions revealed by complementing yeast calmodulin mutants
13. Calmodulin point mutations affect Drosophila development and behavior
14. Calmodulin is involved in regulation of cell proliferation
15. Reduced level of calmodulin in PC12 cells induced by stable expression of calmodulin antisense RNA inhibits cell proliferation and induces neurite outgrowth
16. Calmodulin is required for cell-cycle progression during G1 and mitosis
17. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice
18. Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice
19. Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse
20. Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells
21. Inhibition of calmodulin-activated smooth-muscle myosin light-chain kinase by calmodulin-binding peptides and fluorescent (phosphodiesterase-activating) calmodulin derivatives
22. Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide
23. Expression of a calmodulin inhibitor peptide in progenitor alveolar type II cells disrupts lung development
24. Targeted disruption of Ca (2+)-calmodulin signaling in Drosophila growth cones leads to stalls in axon extension and errors in axon guidance
25. The chicken pre B, cell line DT40. A novel tool for gene disruption experiments
26. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
27. Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene
28. Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature B cell apoptosis
29. Structure and expression of the chicken calmodulin I gene
30. Calcium signaling and cell proliferation
31. Calcium, calmodulin and cell cycle regulation
32. Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast
33. Induction of apoptosis in fibroblasts by c-myc protein
34. Effect of antisense oligodeoxynucleotides directed to individual calmodulin gene transcripts on the proliferation and differentiation of PC12 cells
35. Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone
36. Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, 19q13.2-q13.3
37. Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain
38. Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells
39. Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans
40. Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells
41. Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects
42. Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity
43. 2+/calmodulin is involved in growth factor-induced retinoblastoma gene product phosphorylation in human vascular endothelial cells
44. Ca (2+)-dependent stimulation of retinoblastoma gene product phosphorylation and p34cdc2 kinase activation in serum- stimulated human fibroblasts
45. 2+/CaM kinase)
46. CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G arrest in N1H 3T3 cells
47. The retinoblastoma protein and cell cycle control
48. Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells
49. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
50. 2+/calmodulin-dependent protein kinase II in the mitogen-activated protein kinase signaling cascade of cultured rat aortic vascular smooth muscle cells
51. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase
52. Calmodulin modulates mitogen-activated protein kinase activation in response to membrane depolarization in PC12 cells
53. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21 (cip 1)
54. Calcium influx activates extracellular-regulated kinase/mitogen- activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
55. Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin DI-Cdk4 during G1
56. Myc and the cell cycle
57. Cell lines derived from avian lymphomas exhibit two distinct phenotypes
58. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
59. 2+-induced apoptosis through calcineurin dephosphorylation of BAD
60. Calmodulin activates phosphatidylinositol 3-kinase
61. High affinity calmodulin target sequence in the signalling molecule PI 3-kinase
62. B-lymphocyte activation
63. Inositol trisphosphate and calcium signaling
64. 2+ mobilization
65. D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism
66. ++
67. 2+/calmodulin binds to and modulates P/Q-type calcium channels
68. Calmodulin supports both inactivation and facilitation of L-type calcium channels
69. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma
70. Lymphoma models for B-cell activation and tolerance. II. Growth inhibition by anti-mu of WEHI-231 and the selection and properties of resistant mutants
71. Up-regulation of c-fos expression is a component of the mIg signal transduction mechanism but is not indicative of competence for proliferation
72. Role of phosphoinositide-derived second messengers in mediating anti- IgM-induced growth arrest of WEHI-231 B lymphoma cells
73. Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells
74. Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas
75. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
76. Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis
77. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor
78. 2+/ calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity
79. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity
80. An extracellular role for calmodulin-like activity in cell proliferation
81. Carp muscle calcium-binding protein. II. Structure determination and general description