MTX affects inflammation and tissue destruction differently in the rat AA model

Journal of Rheumatology

Volumn 28, Issue 7, 2001, Pages 1476-1481

  Morgan, S L ^a   Baggott, J E ^a   Bernreuter, W K ^a   Gay, R E ^a   Arani, R ^a   Alarcon G S ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Adjuvant arthritis; Methotrexate; Rheumatoid arthritis

Indexed keywords

METHOTREXATE;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG RESPONSE; FEMALE; HISTOPATHOLOGY; INFLAMMATION; JOINT DESTRUCTION; JOINT RADIOGRAPHY; MORTALITY; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS; SCORING SYSTEM; TREATMENT OUTCOME; WEIGHT GAIN;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BODY WEIGHT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; JOINTS; METHOTREXATE; RATS; RATS, INBRED LEW;

EID: 0034936488     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Development of arthritis, periarthritis, and periosititis in rats given adjuvants
2. Longterm prospective study of methotrexate in rheumatoid arthritis: Conclusion after 132 months of therapy
3. Methotrexate use in rheumatoid arthritis
4. Methotrexate in adjuvant arthritis
5. Elevated levels of TNF in the joints of adjuvant arthritis rats
6. Studies on the effect of low dose methotrexate on rat adjuvant arthritis
7. Low-dose pulse methotrexate inhibits articular destruction of adjuvant arthritis in rats
8. Methotrexate suppresses passive adjuvant arthritis: Studies on the metabolism of methotrexate in mononuclear cells derived from normal and adjuvant arthritis rats
9. The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats
10. Short-term low dose methotrexate ameliorates abnormal bone metabolism and bone loss in adjuvant induced arthritis
11. Increasing methotrexate effect with increasing dose in the treatment or resistant rheumatoid arthritis
12. High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis
13. High dose intravenous methotrexate for refractory rheumatoid arthritis
14. Treatment of rheumatoid arthritis with higher dose intravenous methotrexate
15. Synergy between adjuvant arthritis and collagen-induced arthritis in rats
16. Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls
17. Etiopathogenesis of the rheumatoid-like disease in MRL/I mice. I. The histomorphological basis of joint destruction
18. Studies on the effect of D-penicillamine, gold thioglucose and methotrexate on streptococcal cell wall arthritis
19. Long-term treatment of the mrl/lpr mouse with methotrexate and 10-deaza-aminopterin
20. The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion
21. Retardation of radiologic progression in rheumatoid arthritis with methotrexate therapy
22. Pulse methotrexate therapy in rheumatoid arthritis. A controlled prospective roentgenographic study
23. Radiographic assessment of disease progression in rheumatoid arthritis patients enrolled in the cooperative systematic studies of the rheumatic disease program: Randomized clinical trial of methotrexate, auranofin, or a combination of the two
24. Comparison of azathioprine, methotrexate, and the combination of the two in the treatment of rheumatoid arthritis. A forty-eight week controlled clinical trial with radiologic outcome assessment
25. Combination treatment of rheumatoid arthritis using azathioprine and methotrexate: A 48 week controlled clinical trial
26. Radiologic progression in early rheumatoid arthritis treated with methotrexate
27. Methotrexate and radiographic disease progression in patients with rheumatoid arthritis
28. Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug
29. Early effective suppression of inflammation in rheumatoid arthritis reduced radiographic progression
30. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
31. Combination therapy in early rheumatoid arthritis: A randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components
32. Treatment with leflunomide slows radiographic progression of rheumatoid arthritis
33. Conceptual issues in scoring radiographic progression in rheumatoid arthritis
34. Pathogenesis of joint damage in rheumatoid arthritis
35. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
36. Progressive joint destruction in a human immunodeficiency virus-infected patient with rheumatoid arthritis