Short term low dose methotrexate ameliorates abnormal bone metabolism and bone loss in adjuvant induced arthritis

Journal of Rheumatology

Volumn 24, Issue 10, 1997, Pages 1890-1895

  Suzuki, Yasuo ^a   Nakagawa, Miyako ^a   Masuda, Chieko ^a   Ide, Mikako ^a   Uehara, Ritsuko ^a   Ichikawa, Yoichi ^a   Mizushima, Yutaka ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adjuvant induced arthritis; Methotrexate; Osteopenia

Indexed keywords

METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE DEVELOPMENT; BONE METABOLISM; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; BONE DENSITY; BONE REMODELING; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; METHOTREXATE; OSTEOCALCIN; OSTEOCLASTS; RATS; RATS, INBRED LEW;

EID: 0030862556     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Regab AH, Frech RS, Vietti TJ: Osteoporosis fractures secondary to methotrexate therapy of acute leukemia. Am J Dis Child 1973;126:489-90.
2. Stanisavljevic S, Babcock AL: Fractures in children treated with methotrexate for leukemia. Clin Orthop Rep Res 1977;125:139-44.
3. Schwartz AM, Leonidas JC: Methotrexate osteopathy. Skeletal Radiol 1984;11:13-6.
4. May KP, West SG, McDermott MT, Huffer WE: The effect of low-dose methotrexate on bone metabolism and histomorphometry in rats. Arthritis Rheum 1994;37:201-6.
5. Bywaters EGL: The early radiological signs of rheumatoid arthritis. Bull Rheum Dis 1960;11:231-4.
6. Reid DM, Kennedy NSJ, Nicoll J, Smith MA, Tothill P, Nuki G: Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis. Clin Rheumatol 1986;5:372-8.
7. Hayward M, Fiedler-Nagy C: Mechanisms of bone loss: Rheumatoid arthritis, periodontal disease and osteoporosis. Agents Actions 1987;22:251-4.
8. Shimizu S, Shiozawa S, Shiozawa K, Imura S, Fujita T: Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum 1985;28:25-31.
9. Verstaeten A, Dequeker J: Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: Effect of low dose corticosteroids. Ann Rheum Dis 1986;45:852-7.
10. Sambrook PN, Eisman JA, Champion D, Teates MG, Pocock NA, Eberl S: Determinants of axial bone loss in rheumatoid arthritis. Arthritis Rheum 1987;30:721-8.
11. Laan RFJM, Buijis WCAM, Verbeek ALM, et al: Bone mineral density in patients with recent onset rheumatoid arthritis: Influence of disease activity and functional capacity. Ann Rheum Dis 1993;52:21-6.
12. Kremer J: Methotrexate therapy in the treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1989;15:533-6.
13. Weinblatt ME, Kaplan H, Germain BF, et al: Methotrexate in rheumatoid arthritis. A five-year prospective multicenter study. Arthritis Rheum 1994;37:1492-8.
14. Suzuki Y, Tanihara M, Ichikawa Y, et al: Periarticular osteopenia in adjuvant arthritis: Role of interleukin-1 in decreased osteogenic and increased resorptive potential of bone marrow cells. Ann Rheum Dis 1995;54:484-90.
15. Simmonds DJ, Loeffelman K, Frier C, et al: Circadian changes in the osteogenic competence of marrow stromal cells. In: Kabat E, Hausa E, eds. Chronobiology. Basel: S. Krager, 1984;37-42.
16. Friedlander GE, Tross RB, Doganis AC, Kirkcood JM, Baron R: Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. J Bone Joint Surg 1984;66A:602-7.
17. 3 J Bone Miner Res 1995;10:874-6.
18. May KP, Mercill D, McDermott MT, West SG: The effect of methotrexate on mouse bone cells in culture. Arthritis Rheum 1996;39:489-94.
19. Hattersley G, Kerby JA, Chambers TJ: Identification of osteoclast precursors in multilineage hematopoietic colonies. Endocrinology 1991;128:258-62.
20. btsA58 transgenic mouse. Proc Natl Acad Sci USA 1993;90:55878-82.
21. Pearson CM, Wood FD: Studies of arthritis and other lesions induced in rats by the injection of mycobacterial adjuvant. VII. Pathologic details of the arthritis and spondylitis. Am J Pathol 1963;42:73-95.
22. Segal R, Mozes E, Yaron M, Tartakovsky B: The effect of methotrexate on the production and activity of interleukin-1. Arthritis Rheum 1989;32:370-7.
23. Thomas R, Carroll GJ: Reduction of leukocyte and interleukin-1ß concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum 1993;36:1244-52.
24. Miller LC, Cohen EE, Orencole SF: Interleukin-1ßis structurally related to dihydrofolate reductase: Effects of methotrexate on IL-1 (abstr). Lymphokine Res 1988;7:149.
25. Kremer JM, Galivan J, Streckfuss A, Kamen B: Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients: Association with hepatic folate deficiency and formation of polyglutamates. Arthritis Rheum 1986;29:832-5.
26. Preston SJ, Diamond T, Scott A, Rodger Laurent M: Methotrexate osteopathy in rheumatic disease. Ann Rheum Dis 1993;52:482-5.