Low-dose pulse methotrexate inhibits articular destruction of adjuvant arthritis in rats

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 2, 1997, Pages 213-215

  Kawai, Shinichi ^a   Nagai, Kasumi ^a   Nishida, Shinichi ^a   Sakyo, Katsufumi ^b   Murai, Etsuko ^b   Mizushima, Yutaka ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Lederle (Japan) Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; RAT; RHEUMATOID ARTHRITIS; X RAY;

EID: 0031045692     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06782.x     Document Type: Article

References (13)

1. Arend, W. P., Dayer, J.-M. (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum. 38: 151-160
2. Clark, R. L., Cuttino, J. T., Anderle, S. K., Cromartie, W. J., Schwab, J. H. (1979) Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls. Arthritis Rheum. 22: 25-35
3. Connolly, K. M., Stecher, V. J., Danis, E., Pruden, D. J., LaBrie, T. (1988) Alteration of interleukin-1 production and the acute phase response following medication of adjuvant arthritic rats with cyclosporin-A or methotrexate. Int. J. Immunopharmacol. 10: 717-728
4. Furst, D. E., Kremer, J. M. (1988) Methotrexate in rheumatoid arthritis. Arthritis Rheum. 31: 305-314
5. Herborn, R. R. G., Karger, T., Werdier, D. (1991) Retardation of radiologic progression in rheumatoid arthritis with methotrexate therapy: a controlled study. Arthritis Rheum. 34: 1236-1244
6. Hu, S. K., Mitcho, Y. L., Oronsky, A. L., Kerwar, S. S. (1988) Studies on the effects of methotrexate on macrophage function. J. Rheumatol. 15: 206-209
7. Kerwar, S. S., Oronsky, A. L. (1989) Methotrexate in rheumatoid arthritis: studies with animal models. Adv. Enzyme Regul. 29: 247-265
8. Nordstrom, D. M., West, S. G., Andersen, P. A., Sharp, J. T. (1987) Pulse methotrexate therapy in rheumatoid arthritis: a controlled prospective roentgenographic study. Ann. Intern. Med. 107: 797-801
9. Segal, R., Yaron, M., Tartakovsky, B. (1990) Methotrexate: mechanism of action in rheumatoid arthritis. Sem. Arthritis Rheum. 20: 190-199
10. Smith-Oliver, T., Noel, L. S., Stimpson, S. S., Yamall, D. P., Connolly, K. M. (1993) Elevated levels of the TNF in the joints of adjuvant arthritic rats. Cytokine 5: 298-304
11. Tatakis, D. N. (1993) Interleukin-1 and bone metabolism: a review. J. Periodontal. 64: 416-431
12. van de Loo, F. A. J., Joosten, L. A. B., van Lent, P. L. E. M., Arnts, O. J., van den Berg, W. B. (1995) Role of interleukin-1, tumor necrosis factor α, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Arthritis Rheum. 38: 164-172
13. Welles, W. L., Silkworth, J., Oronsky, A. L., Kerwar, S. S., Galivan, J. (1985) Studies on the effects of low dose methotrexate on rat adjuvant arthritis. J. Rheumatol. 12: 904-906