Acute effects of triazolam in women: Relationships with progesterone, estradiol and allopregnanolone

Psychopharmacology

Volumn 130, Issue 1, 1997, Pages 69-78

  De Wit, Harriet ^a   Rukstalis, Margaret ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Allopregnanolone; Benzodiazepine; Hormones; Menstrual; Subjective effects

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; ESTRADIOL; PLACEBO; PROGESTERONE; TRIAZOLAM;

ADULT; AROUSAL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FOLLICULAR PHASE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LUTEAL PHASE; MENSTRUAL CYCLE; MOOD; NORMAL HUMAN; OVULATION; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE;

ADOLESCENT; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ESTRADIOL; FEMALE; HUMANS; NEUROPROTECTIVE AGENTS; PREGNANOLONE; PROGESTERONE; TIME FACTORS; TRIAZOLAM;

EID: 0031026948     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050212     Document Type: Article

References (46)

1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. APA, Washington, D.C.
2. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993) Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237-243
3. Backstrom T, Bixo M, Hammarback S (1985) Ovarian steroid hormones: effects on mood, behavior and brain excitability. Acta Obstet Gynecol Scand Suppl 130:19-24
4. Batista MC, Cartledge TP, Zellmer AW, Nieman LK, Merriam GR, Loriaux DL (1992) Evidence for a critical role of progesterone in the regulation of the midcycle gonadotropin surge and ovulation. J Clin Endocrinol Metab 74:565-570
5. Baulieu EE (1981) Steroid hormones in the brain: several mechanisms? In: Fuxe K, Gustafsson JA, Wetterberg L (eds) Steroid hormone regulation of the brain. Pergamon Press, Oxford, pp 3-14
6. Becker JB, Beer ME (1986) The influence of estrogen on nigrostriatal dopamine activity: behavioral and neurochemical evidence for both pre- and postsynaptic components. Behav Brain Res 19:27-33
7. Belelli D, Bolger MB, Gee KW (1989) Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol 166:325-329
8. Corpéchot C, Young J, Calvel M, Wehrey C, Velts JN, Touyer G, Mouren M, Prasad VVK, Banner C, Sjövall J, Baulieu EE, Robel P (1993) Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinolgy 133:1003-1009
9. Crawley JN, Glowa JR, Majewska MD, Paul S (1986) Anxiolytic activity of an endogenous adrenal steroid. Brain Res 398:382-385
10. Derogatis L (1983) SCL-90-R Manual-II. Clinical psychometric research. Towson, Md.
11. de Wit H, Griffiths RR (1991) Methods of assessing the abuse liability of sedatives in humans. Drug Alcohol Depend 28:83-111
12. Donner A (1984) Linear regression analysis with repeated measurements. J Chron Dis 37:441-448
13. Freeman EW, Purdy RH, Coutifaris C, Rickels K, Paul SM (1993) Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. Neuroendocrinology 58:478-484
14. A receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol 44:191-197
15. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996) Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in female Macaca vescicularis monkeys. Psychopharmacology 124:340-346
16. Greenblatt DJ, Divoll M, Moschitto LJ, Shader RI (1981) Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam. J Chromatogr 225:202-207
17. Greenblatt DJ, Abernethy DR Divoll M, Harmatz JS Shader RI (1983a) Pharmacokinetic properties of benzodiazepine hypnotics. J Clin Psychopharmacol 3:129-132
18. Greenblatt DJ, Divoll M, Abernethy DR, Ochs HR, Shader RI (1983b) Clinical pharmacokinetics of the newer benzodiazepines. Clin Pharmacokinet 8:233-252
19. A receptor complex. J Pharmacol Exp Ther 241:346-353
20. Hindmarch I, Kerr JS, Sherwood N (1991) The effects of alcohol and other drugs on psychomotor performance and cognitive function. Alcohol Alcohol 26:71-79
21. Holzbauer M (1971) In vivo production of steroids with central depressant actions by the ovary of the rat. Br J Pharmacol 43:560-569
22. Hu ZY, Bourreau E, Jung-Testas I, Robel P, Baulieu EE (1987) Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc Natl Acad Sci USA 84:8215-8219
23. Jung-Testas I, Hu ZY, Baulieu EE, Robel P (1989) Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125:2083-2091
24. Kelly MJ, Moss RL, Dudley CA (1977) The effects of microelectrophoretically applied estrogen, cortisol and acetylcholine on medial preoptic-septal unit activity throughout the estrous cycle of the female rat. Exp Brain Res 30:53-64
25. Leibenluft, E, Fiero PL, Rubinow DR (1994) Effects of the menstrual cycle on dependent variables in mood disorder research. Arch Gen Psychiatry 51:761-781
26. A receptors. Science 232:1004-1007
27. 3H]flunitrazepam binding by natural and synthetic progestational agents. Pharmacol Biochem Behav 45:77-83
28. McAuley JW, Reynolds IJ, Kroboth FJ, Smith RB, Kroboth PD (1995) Orally administered progesterone enhances sensitivity to triazolam in postmenopausal women. J Clin Psychopharm 15:3-11
29. McNair D, Lorr M, Droppleman DL (1971) Profile of mood states. Educational and Industrial Testing Service, San Diego
30. Mendelson WB, Martin JV, Perlis M, Wagner R, Majewska MD, Paul SM (1987) Sleep induction by an adrenal steroid in the rat. Psychopharmacology 93:226-229
31. Mitchell SH, Laurent CL, de Wit H (1996) Interaction of expectancy and the pharmacological effects of d-amphetamine: subjective effects and self-administration. Psychopharmacology 125:371-378
32. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6: 2311-2322
33. Phillips SM, Sherwin BB (1992) Variations in memory function and sex steroid hormones across the menstrual cycle. Psychoneuroendocrinology 17:497-506
34. Purdy RH, Moore PH, Ruo PN, Hagino N, Yamaguchi T, Schmidt P, Rubinow DR, Morrow AL, Paul SM (1990) Radioimmunoassay of 3 alpha-hydroxy-5 alpha-pregnane-20-one in rat and human plasma. Steroids 55:290-296
35. Roache JD, Griffiths RR (1985) Comparison of triazolam and pentobarbital: performance impairment, subjective effects and abuse liability. J Pharmacol Exp Ther 234:120-133
36. Rosenfield RL, Barnes RB, Ehrmann DA (1994) Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 79:1686-1692
37. Rossmanith WG, Lauritzen C (1991) The luteinizing hormone pulsatile secretion: diurnal excursions in normally cycling and postmenopausal women. Gynecol Endocrin 5:249-265
38. Rush CR, Higgins ST, Hughes JR, Bickel W (1993) A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers. Psychopharmacology 112:407-414
39. A receptors in dorsal hippocampus by estradiol and progesterone. Brain Res 487:187-183
40. Selye H (1941) The anesthetic effect of steroid hormones. Proc Soc Exp Biol Med 46:116-121
41. A receptor complex. Neuropharmacology 23:877-878
42. Smith SS (1994) Female sex steroid hormones: from receptors to networks to performance - actions on the sensorimotor system. Prog Neurobiol 44:55-86
43. Smith SS, Waterhouse BD, Woodward DJ (1987) Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum. Brain Res Bull 18:739-747
44. Stern KN, McClintock MK (1996) Individual variation in biological rhythms: accurate measurement of preovulatory LH surge and menstrual cycle phase. In: Jensvold MF, Halbreich U, Hamilton JA (eds) Psychopharmacology and women: sex, gender and hormones. American Psychiatric Press, Washington, DC
45. Wechsler D (1958) The measure and appraisal of adult intelligence. Williams and Wilkins, Baltimore, Md.
46. Wilson JD, Foster DW (1985) Textbook of endocrinology, 9th edn. Saunders, Philadelphia, Pa.