Modulation of the apoptotic response: Potential for improving the outcome in clinical radiotherapy

Seminars in Radiation Oncology

Volumn 6, Issue 4, 1996, Pages 273-283

  Haimovitz Friedman, A ^a   Kolesnick, R N ^a   Fuks, Z ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CERAMIDE;

APOPTOSIS; ARTICLE; CELL MEMBRANE; DNA DAMAGE; ETIOLOGY; HUMAN; LUNG INJURY; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION RESPONSE; RADIOTHERAPY; SIGNAL TRANSDUCTION;

EID: 0029965593     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-4296(96)80023-3     Document Type: Article

References (104)

1. [Review] Fuks Z Leibel SA Kutcher GJ Three-dimensional conformal treatment: a new frontier in radiation therapy Important Adv Oncol 1991 151 172
2. Ward WF Sharplin J Franko AJ Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice Radiat Res 120 1989 113 120
3. Radford IR Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells Int J Radiat Biol Rel Studies Phys Chem Med 49 1986 611 620
4. Dewey WC Miller HH Leeper DB Chromosomal aberrations and mortality of x-irradiated mammalian cells: Emphasis on repair Proc Natl Acad Sci USA 68 1971 667 671
5. [Review] Steel GG McMillan TJ Peacock JH The radiobiology of human cells and tissues. In vitro radiosensitivity. The picture has changed in the 1980s Int J Radiat Biol 56 1989 525 537
6. Bedford JS Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations Int J Radiat Oncol Biol Phys 21 1991 1457 1469
7. Thompson LH Suit HD Proliferation kinetics of x-irradiated mouse L cells studied with time-lapse photography Int J Radiat Biol Rel Studies Phys Chem Med 15 1969 347 362
8. Hurwitz C Tolmach LJ Time lapse cinemicrographic studies of x-irradiated HeLa S3 cells. I. Cell progression and cell disintegration Biophys J 9 1969 607 633
9. Wyllie AH Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation Nature 284 1980 554 556
10. Vaux DL Toward an understanding of the molecular mechanisms of physiological death Proc Natl Acad Sci USA 90 1993 786 789
11. Duvall E Wyllie AH Morris RG Macrophage recognition of cells undergoing programmed cell death (apoptosis) Immunology 56 1985 351 358
12. Allan DJ Radiation-induced apoptosis: Its role in a MADCaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms Int J Radiat Biol 62 1992 145 152
13. [Review] Dewey WC Ling CC Meyn RE Radiation-induced apoptosis: Relevance to radiotherapy Int J Radiat Oncol Biol Phys 33 1995 781 796
14. Olive PL Frazer G Banath JP Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay Radiat Res 136 1993 130 136
15. McKenna WG Bernhard EJ Markiewicz DA Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: Influence of H-ras on the G2 delay Oncogene 12 1996 237 245
16. [Review] Hendry JH Survival of cells in mammalian tissues after low doses of irradiation: a short review Int J Radiat Biol Rel Studies Phys Chem Med 53 1988 89 94
17. Stephens LC Hunter NR Ang KK Development of apoptosis in irradiated murine tumors as a function of time and dose Radiat Res 135 1993 75 80
18. Meyn RE Stephens LC Ang KK Heterogeneity in the development of apoptosis in irradiated murine tumours of different histologies Int J Radiat Biol 64 1993 583 591
19. Fuks Z Alfieri A Haimovitz-Friedman A Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo Cancer J 1 1995 62 72
20. Meyn RE Stephens LC Hunter NR Reemergence of apoptotic cells between fractionated doses in irradiated murine tumors Int J Radiat Oncol Biol Phys 30 1994 619 624
21. [see comments] Ling CC Chen CH Fuks Z An equation for the dose response of radiation-induced apoptosis: Possible incorporation with the LQ model Radiother Oncol 33 1994 17 22
22. Charlton DE The range of high LET effects from 125I decays Radiat Res 107 1986 163 171
23. Martin RF Haseltine WA Range of radiochemical damage to DNA with decay of iodine-125 Science 213 1981 896 898
24. Radford IR Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin Int J Radiat Biol 65 1994 203 215
25. Story MD Voehringer DW Malone CG Radiation-induced apoptosis in sensitive and resistant cells isolated from a mouse lymphoma Int J Radiat Biol 66 1994 659 668
26. Warters RL Hofer KG Harris CR Radionuclide toxicity in cultured mammalian cells: Elucidation of the primary site of radiation damage Curr Top Radiat Res Q 12 1978 389 407
27. Hofer KG Harris CR Smith JM Radiotoxicity of intracellular 67Ga, 125I and 3H. Nuclear versus cytoplasmic radiation effects in murine L1210 leukaemia Int J Radiat Biol Rel Studies Phys Chem Med 28 1975 225 241
28. Yasui LS Hofer KG Role of mitochondrial DNA in cell death induced by 125I decay Int J Radiat Biol Rel Studies Phys Chem Med 49 1986 601 610
29. Kassis AI Adelstein SJ Haydock C Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells Radiat Res 90 1982 362 373
30. Ashwell JD Schwartz RH Mitchell JB Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement J Immunol 136 1986 3649 3656
31. Macklis RM Lin JY Beresford B Cellular kinetics, dosimetry, and radiobiology of alpha-particle radioimmunotherapy: Induction of apoptosis Radiat Res 130 1992 220 226
32. Haimovitz-Friedman A Kan C Ehleiter D Ionizing radiation acts on cellular membranes in human leukemia cells to generate ceramide and induce apoptosis J Exp Med 180 1994 525 535
33. Verheij M Bose R Lin XH Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Nature 380 1996 75 79
34. Radford IR Murphy TK Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage Int J Radiat Biol 65 1994 229 239
35. Kastan MB Zhan Q el-Deiry WS A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell 71 1992 587 597
36. [Review] Hartwell LH Kastan MB Cell cycle control and cancer Science 266 1994 1821 1828
37. [Review] Canman CE Kastan MB Induction of apoptosis by tumor suppressor genes and oncogenes Semin Cancer Biol 6 1995 17 25
38. [Review] Lee JM Bernstein A Apoptosis, cancer and the p53 tumour suppressor gene Cancer Metastasis Rev 14 1995 149 161
39. [Review] Meyn MS Ataxia-telangiectasia and cellular response to DNA damage Cancer Res 55 1995 5991 6001
40. Donehower LA Harvey M Slagle BL Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature 356 1992 215 221
41. [Review] Perry ME Levine AJ Tumor-suppressor p53 and the cell cycle Curr Opin Genet Devel 3 1993 50 54
42. [see comments] Lowe SW Schmitt EM Smith SW p53 is required for radiation-induced apoptosis in mouse thymocytes Nature 362 1993 847 849
43. [see comments] Clarke AR Purdie CA Harrison DJ Thymocyte apoptosis induced by p53-dependent and independent pathways Nature 362 1993 849 852
44. Wu X Levine AJ p53 and E2F-1 cooperate to mediate apoptosis Proc Natl Acad Sci USA 91 1994 3602 3606
45. Rowan S Ludwig RL Haupt Y Specific loss of napoptotic but not cell cycle arrest function in human derived p53 mutant EMBO J 15 1996 827 838
46. [Review] Oliner JD Discerning the function of p53 by examining its molecular interactions Bioessays 15 1993 703 707
47. [Review] Prives C How loops, beta sheets, and alpha helices help us to understand p53 Cell 78 1994 543 546
48. [see comments] Caelles C Helmberg A Karin M p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes Nature 370 1994 220 223
49. Wagner AJ Kokontis JM Hay N Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 wafl/cipI Genes Dev 8 1994 2817 2830
50. Canman CE Gilmer TM Coutts SB Growth factor modulation of p53-mediated growth arrest versus apoptosis Genes Dev 9 1995 600 611
51. Purdie CA Harrison DJ Peter A Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene Oncogene 9 1994 603 609
52. Symonds H Krall L Remington L p53-dependent apoptosis in vivo: Impact of p53 inactivation on tumorigenesis Cold Spring Harb Symp Quant Biol 59 1994 247 257
53. Lotem J Sachs L Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents Blood 82 1993 1092 1096
54. Merritt AJ Potten CS Kemp CJ The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice Cancer Res 54 1994 614 617
55. Clarke AR Gledhill S Hooper ML p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation Oncogene 9 1994 1767 1773
56. [Review] Levine AJ The tumor suppressor genes Annu Rev Biochem 62 1993 623 651
57. Cordon-Cardo C Latres E Drobnjak M Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas Cancer Res 54 1994 794 799
58. [see comments] Strasser A Harris AW Jacks T DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 Cell 79 1994 329 339
59. [Review] Lowe SW Cancer therapy and p53 Curr Opin Oncol 7 1995 547 753
60. [Review] Hartwell LH Weinert TA Checkpoints: Controls that ensure the order of cell cycle events Science 246 1989 629 634
61. [Review] Pines J Hunter T p34cdc2: The S and M kinase? New Biol 2 1990 389 401
62. [Review] Nurse P Universal control mechanism regulating onset of M-phase Nature 344 1990 503 508
63. [Review] Clarke PR Karsenti E Regulation of p34cdc2 protein kinase: New insights into protein phosphorylation and the cell cycle J Cell Sci 100 1991 409 414
64. Kharbanda S Saleem A Datta R Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2 Cancer Res 54 1994 1412 1414
65. Muschel RJ Zhang HB McKenna WG Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells Cancer Res 53 1993 1128 1135
66. [Review] Maity A McKenna WG Muschel RJ The molecular basis for cell cycle delays following ionizing radiation: A review Radiother Oncol 31 1994 1 13
67. Hwang A Maity A McKenna WG Cell cycledependent regulation of the cyclin B1 promoter J Biol Chem 270 1995 28419 28424
68. Maity A McKenna WG Muschel RJ Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells EMBO J 14 1995 603 609
69. Kharbanda S Yuan ZM Rubin E Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation J Biol Chem 269 1994 20739 20743
70. [Review] D'Amico AV McKenna WG Apoptosis and a re-investigation of the biologic basis for cancer therapy Radiother Oncol 33 1994 3 10
71. Palayoor ST Macklis RM Bump EA Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells Radiat Res 141 1995 235 243
72. Langley RE Quartuccio SG Kennealey PT Effect of cell cycle stage, dose rate and repair of sublethal damage on radiation-induced apoptosis in F9 teratocarcinoma cells Radiat Res 144 1995 90 96
73. Chen CH Zhang J Ling CC Transfected c-myc and c-Haras modulate radiation-induced apoptosis in rat embryo cells Radiat Res 139 1994 307 315
74. Ling CC Guo M Chen CH Radiation-induced apoptosis: Effects of cell age and dose fractionation Cancer Res 55 1995 5207 5212
75. Bernhard EJ Maity A Muschel RJ Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine Radiat Res 140 1994 393 400
76. Tartaglia LA Ayres TM Wong GH A novel domain within the 55 kd TNF receptor signals cell death Cell 74 1993 845 853
77. Wiegmann K Schutze S Machleidt T Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling Cell 78 1994 1005 1015
78. Chinnaiyan AM Tepper CG Seldin MF FADD/MORT1 is a common mediator of CD95 (FAS/APO-1) and tumor necrosis ractor receptor-induced apoptosis J Biol Chem 271 1966 4961 4965
79. Kolesnick R Golde DW The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling Cell 77 1994 325 328
80. Hannun YA The sphingomyelin cycle and second messenger function of ceramide J Biol Chem 269 1994 3125 3128
81. Obeid LM Linardic CM Karolak LA Programmed cell death by ceramide Science 259 1993 1769 1771
82. Jarvis WD Kolesnick RN Fornari FA Induction of apoptotic DNA fragmentation and cell death by activation of the sphingomyelin pathway Proc Natl Acad Sci USA 91 1994 73 77
83. [Review] Pushkareva M Obeid LM Hannun YA Ceramide: An endogenous regulator of apoptosis and growth suppression Immunol Today 16 1995 294 297
84. [see comments] Boucher LM Wiegmann K Futterer A CD28 signals through acidic sphingomyelinase J Exp Med 181 1995 2059 2068
85. Gulbins E Bissonnette R Mahboubi A Fas-induced apoptosis is mediated via a ceramide-initiated ras signaling pathway Immunity 2 1995 341 351
86. Kyriakis JM Banerjee P Nikolakaki E The stress-activated protein kinase subfamily of c-Jun kinases Nature 369 1994 156 160
87. Dérijard B Raingeaud J Barrett T Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms Science 267 1995 682 685
88. Sánchez I Hughes RT Mayer BJ Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun Nature 372 1994 794 798
89. Yan M Dai T Deak JC Activation of stress-activated protein kinase by MEKKI phosphorylation of its activator SEK1 Nature 372 1994 798 800
90. Lin A Minden A Martinetto H Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 Science 268 1995 286 290
91. Jarvis WD Fornari FA Browning JL Attenuation of ceramide-induced apoptosis in human myeloid leukemia cells J Biol Chem 269 1994 31658 31692
92. Hallahan DE Virudachalam S Schwartz JL Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation Radiat Res 29 1992 345 350
93. Kim CY Giaccia AJ Strulovici B Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation Br J Cancer 66 1992 844 849
94. Hallahan DE Virudachalam S Sherman MA Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation Cancer Res 51 1991 4565 4569
95. Hallahan DE Virudachalam S Gardina D The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-rayinduced G2 arrest Int J Radiat Oncol Biol Phys 24 1992 687 692
96. Uckun FM Schieven GL Tuel-Ahlgren LM Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors Proc Natl Acad Sci USA 90 1993 252 256
97. Fuks Z Persaud RS Alfieri A Basic fibroblast growth factor protects endothelial cells from radiation-induced programmed cell death in vitro and in vivo Cancer Res 54 1994 2582 2590
98. Haimovitz-Friedman A Balaban NA McLoughlin M Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis Cancer Res 54 1994 2591 2597
99. Xia Z Dickens M Raingeaud J Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270 1995 1326 1331
100. Fuks Z Alfieri A Haimovitz-Friedman A Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo Cancer J Sci Am 1 1995 62 72
101. Adamson IYR Bowden DH Endothelial injury and repair in radiation-induced pulmonary fibrosis Am J Pathol 112 1983 224 230
102. Law MP Ahier RG Vascular and epithelial damage in the lung of the mouse after x rays and neutrons Radiat Res 17 1989 128 144
103. Penney DP Rubin P Specific early fine structural changes in the lung irradiation Int J Radiat Oncol Biol Phys 2 1977 1123 1132
104. Penney DP Siemann DW Rubin P Morphologic changes reflecting early and late effects of irradiation of the distal lung of the mouse: A review Scanning Electron Microsc 1 1982 413 425