Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats

International Journal of Cardiology

Volumn 79, Issue 2-3, 2001, Pages 215-221

  Coelho Filho, O R ^a   De Luca, I M S ^a   Tanus Santos, J E ^a   Cittadino, M ^a   Sampaio, R C ^a   Coelho, O R ^a   Hyslop, S ^a   Moreno, Jr ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Endothelium; HMG CoA reductase inhibitors; Hypertension; L NAME; Myocardial infarction; Pravastatin; Thromboxane

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PENTOBARBITAL; PRAVASTATIN; THROMBOXANE B2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIOSYNTHESIS; BLOOD LEVEL; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE INJURY; HEART MUSCLE NECROSIS; HEART PROTECTION; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTICHOLESTEREMIC AGENTS; CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NECROSIS; NG-NITROARGININE METHYL ESTER; NITRATES; NITRIC OXIDE SYNTHASE; NITRITES; PRAVASTATIN; RATS; RATS, WISTAR; THROMBOXANE B2;

EID: 0034925769     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(01)00423-5     Document Type: Article

References (32)

1. Beneficial effects of statins
2. Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats
3. Effects of dietary fatty acids on lipoproteins and cardiovascular disease risk: Summary
4. Effects of dietary cholesterol on hepatic production of lipids and lipoproteins in isolated hamster liver
5. Inhibitory effect of fluvastatin at doses insufficient to lower serum lipids on the catheter-induced thickening of intima in rabbit femoral artery
6. Rapid reversal of endothelial dysfunction in hypercholesterolaemic rabbits treated with simvastatin and pravastatin
7. Dietary fat saturation on low-density-lipoprotein concentrations in various animal models
8. Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic mediterranean population: The Carotid Atherosclerosis Italian Ultrasound Study
9. Lipoproteins and cardiovascular reactivity
10. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial
11. Beyond lipids - The role of endothelium in coronary artery disease
12. Effects of simvastatin and pravastatin on endothelium-dependent relaxation in hypercholesterolemic rabbits
13. Non-specific inhibitors of nitric oxide syntase cause myocardial necrosis in the rat
14. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
15. A low cost tail-cuff method for the estimation of mean arterial pressure in conscious rats
16. Plasma nitrate as an index of nitric oxide formation in man: Analyses of kinetics and confounding factors
17. Stereological methods
18. Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart
19. Reduced nitric oxide formation causes coronary vasoconstriction and impaired dilator responses to endogenous agonists and hypoxia in dogs
20. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts
21. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
22. Statins do more than just lower cholesterol
23. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions
24. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
25. Nonenzymatic nitric oxide production in humans
26. Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice
27. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation
28. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels
29. Inhibition of proinflammatory cytokine production by pravastatin
30. Statins and monocytes
31. Long-term effects of pravastatin on plasma concentration of C-reactive protein
32. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase and and promotes angiogenesis in normocholesterolemic animals