Dietary fat saturation effects on low-density-lipoprotein concentrations and metabolism in various animal models

American Journal of Clinical Nutrition

Volumn 65, Issue 5 SUPPL., 1997, Pages

  Nicolosi, Robert J ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

Author keywords

animal studies; cholesterol; fatty acid; fractional catabolic rate; LDL; Lipoprotein; low density lipoprotein; polyunsaturated fat; production rate; saturated fat

Indexed keywords

ACYLTRANSFERASE; COCONUT OIL; EDIBLE OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PALM OIL; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; UNSATURATED FATTY ACID; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; BABOON; CONFERENCE PAPER; FAT INTAKE; GUINEA PIG; LIPOPROTEIN METABOLISM; MALE; MONKEY; NONHUMAN; SYRIAN HAMSTER;

ANIMALIA; CAVIA PORCELLUS; COCOS NUCIFERA; CRICETINAE; MESOCRICETUS AURATUS; PAPIO HAMADRYAS; SUS SCROFA;

EID: 0031002327     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.5.1617S     Document Type: Conference Paper

References (32)

1. Fernandez ML, Lin ECK, McNamara DJ. Differential effects of saturated fatty acids on low density lipoprotein. J Lipid Res 1992;33:1833-42.
2. Fernandez ML, Abdel-Fattah G, McNamara DJ. Dietary fat saturation modifies the metabolism of LDL subfractions in guinea pigs. Arterioscler Thromb 1993;13:1418-28.
3. Stucchi AF, Terpstra AHM, Nicolosi RJ. LDL receptor activity is down regulated similarly by a diet high in palmitic acid, or high in lauric and myristic acid in cynomolgus monkeys. J Nutr 1995;125:2055-63.
4. Woollett LA, Spady DK, Dietschy JM. Mechanisms by which saturated triacylglycerols elevate the plasma low density lipoprotein-cholesterol concentration in hamsters. Differential effects of fatty acid chain length. J Clin Invest 1989;84:119-28.
5. Daumerie CM, Woollett LA, Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci U S A 1992;89: 10797-801.
6. Woollett LA, Spady DK, Dietschy JM. Regulatory effects of the saturated fatty acids 6:0 through 18:0 on hepatic low density lipoprotein receptor activity in the hamster. J Clin Invest 1992;89:1133-41.
7. Woollett LA, Daumerie CM, Dietschy JM. Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster. J Lipid Res 1994;35:1661-73.
8. Spady DK, Dietschy JM. Interaction of dietary cholesterol and triacylglycerols in the regulation of hepatic low density lipoprotein transport in the hamster. J Clin Invest 1988;81:300-9.
9. Woollett LA, Spady DK, Dietschy JM. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate J Lipid Res 1992;33:77-88.
10. Horton JD, Cuthbert JA, Spady D. Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels. J Clin Invest 1993;92:743-9.
11. Hennessy LK, Osada J, Ordovas JM, et al. Effects of dietary fats and cholesterol on liver lipid content and hepatic apolipoproteins A-1, B, and E and LDL receptor mRNA levels in cebus monkeys. J Lipid Res 1992;33:351-60.
12. Fox JC, McGill HC Jr, Carey KD, Getz GS. In vivo regulation of hepatic LDL receptor mRNA in the baboon. Differential effects of saturated and unsaturated fat. J Biol Chem 1987;262:7014-20.
13. Kushwaha RD, McMahan Ca, Mott GE, et al. Influence of dietary lipids on hepatic mRNA level of proteins regulating plasma lipoproteins in baboons with high and low levels of large high density lipoproteins. J Lipid Res 1991;32:1929-40.
14. Sorci-Thomas M, Wilson MD, Johnson FL, Williams DL, Rudel LL. Studies on the expression of genes encoding apoplipoproteins B100 and B48 and the low density lipoprotein receptor in nonhuman primates. J Biol Chem 1989;264:9039-45.
15. Fernandez ML, Lin Eck, McNamara DJ. Regulation of guinea pig plasma low density lipotrotein kinetics by dietary fat saturation. J Lipid Res 1992;33:97-100.
16. Fernandez ML, McNamara DJ. Dietary fat-mediated changes in hepatic apoprotein B/E receptor in the guinea pig: effect of polyunsaturated, monounsaturated, and saturated fat. Metabolism 1989;38:1094-102.
17. Fernandez ML, McNamara DJ. Regulation of cholesterol and lipoprotein metabolism in guinea pigs mediated by dietary fat quality and quantity. J Nutr 1991;121:934-43.
18. Lin ECK, Fernandez ML, Tosca MA, McNamara DJ. Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol. J Lipid Res 1994;35:446-57.
19. Pronczuk A, Kosla P, Hayes KC. Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. FASEB J 1994;8:1191-200.
20. Nicolosi RJ, Marlett JA, Morello AM, Flanagan SA, Hegsted DM. Influence of dietary unsaturated and saturated fat on the plasma lipoproteins of Mongolian gerbils. Atherosclerosis 1981;38:359-71.
21. Nicolosi RM, Stucchi AF, Kowala MC, Hennessy LK, Hegsted DM, Schaefer EJ. Effect of dietary fat saturation and cholesterol on LDL composition and metabolism. In vivo studies of receptor and non-receptor-mediated catabolism of LDL in cebus monkeys. Arterioscler Thromb 1990;10:119-28.
22. Brousseau ME, Stucchi AF, Vespa DB, Schaeffer EJ, Nicolosi RJ. Diets enriched in monounsaturated fats decreases low density lipoprotein concentration in cynomolgus monkeys by a different mechanism than does a diet enriched in polyunsaturated fats. J Nutr 1993;123:2049-58.
23. Hunt CE, Funk GM, Vidmar TJ. Dietary polyunsaturated to saturated fatty acid ratio alters hepatic LDL transport in cynomolgus macaques fed low cholesterol diets. J Nutr 1993;122:1960-70.
24. Weight MJ, Benade AJS, Lombard CJ, et al. Low density lipoprotein kinetics in African green monkeys showing variable cholesterolemic responses to diets realistic for Westernized people. Atherosclerosis 1988;73:1-11.
25. Rudel LL, Haines JL, Sawyer JK. Effects on plasma lipoproteins of monounsaturated, saturated, and polyunsaturated fatty acids in the diet of African green monkeys. J Lipid Res 1990;31:1873-82.
26. McGill HC Jr, McMahan CA, Kruski AW, Kelley JL, Mott GE. Responses of serum lipoproteins to dietary cholesterol and type of fat in the baboon. Arterioscler Thromb 1981;1:337-44.
27. Babiak J, Nichols AV, Gong EL, et al. Effects of dietary polyunsaturated and saturated fats on lipoproteins in the baboon. Atherosclerosis 1985;57:1-17.
28. Mott GE, Jackson EM, McMahan CE, McGill HC Jr. Dietary cholesterol and type of fat differentially affect cholesterol metabolism in baboons. J Nutr 1992;122:1397-406.
29. Khosla P, Hayes KC. Comparison between the effects of dietary saturated (16:0), monounsaturated (18:1), and polyunsaturated (18:2) fatty acids on plasma lipoprotein metabolism in cebus and rhesus monkeys fed cholesterol-free diets. Am J Clin Nutr 1992;55:51-62.
30. Hayes KC, Pronczuk A, Lindsey S, Diersen-Schade D. Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates. Am J Clin Nutr 1991;53:491-8.
31. Khosla P, Hayes KC. Dietary palmitic acid raises plasma LDL cholesterol relative to oleic acid only at a high intake of cholesterol. Biochim Biophys Acta 1993;1210:13-22.
32. Hayes KC, Khosla P. Dietary fatty acid thresholds and cholesterolemia. FASEB J 1992;6:2600-7.