It ain't over till it's ova: Germline sex determination in C. elegans

BioEssays

Volumn 23, Issue 7, 2001, Pages 596-604

  Kuwabara, Patricia E ^a   Perry, Marc D ^b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; FEM 3 PROTEIN, C ELEGANS; FEM-3 PROTEIN, C ELEGANS; HELMINTH PROTEIN; MEMBRANE PROTEIN; TRA 2 PROTEIN, C ELEGANS; TRA-2 PROTEIN, C ELEGANS;

ANIMAL; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL DIVISION; CYTOLOGY; GENDER AND SEX; GENETICS; GERM CELL; OOCYTE; REVIEW; RNA PROCESSING;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; GERM CELLS; HELMINTH PROTEINS; MEMBRANE PROTEINS; OVUM; RNA PROCESSING, POST-TRANSCRIPTIONAL; SEX DETERMINATION (GENETICS);

EID: 0034923465     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1085     Document Type: Review

References (67)

1. Sex determination in the Drosophila germline is dictated by the sexual identity of the surrounding soma
2. Vive la difference: Males vs females in flies vs worms
3. Developmental genetics of Caenorhabditis Elegans sex determination
4. A genetic analysis of the sex determining gene, tra-1, in the nematode Caenorhabditis elegans
5. Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins
6. Possible evolutionary conservation of sex determining genes
7. Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation
8. Moving up the hierarchy: A hypothesis on the evolution of a genetic sex determination pathway
9. tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway
10. Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3
11. Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in Caenorhabditis elegans
12. Germ-line regulation of the C. elegans sex-determining gene tra-2
13. Proteolysis in C. elegans sex determination: Cleavage of TRA-2A by the calpain TRA-3
14. Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination
15. Sex-specific transcriptional regulation of the C. elegans sex-determining gene her-1
16. The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase
17. Caenorhabditis elegans sex-determining protein FEM-2 is a protein phosphatase that promotes male development and interacts directly with FEM-3
18. Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans
19. The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex
20. Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate
21. Fluorescence visualization of the distribution of microfilaments in gonads and early embryos of the nematode Caenorhabditis elegans
22. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis
23. On the control of germ cell development in Caenorhabditis elegans
24. The LIN-12/Notch signaling pathway and its regulation
25. Soma-germ cell interactions in Caenorhabditis elegans: Multiple events of hermaphrodite germline development require the somatic sheath and spermathecal lineages
26. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline
27. A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans
28. fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans
29. fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans
30. The fog-3 gene and regulation of cell fate in the germline of Caenorhabditis elegans
31. The mog-1 gene is required for the switch from spermatogenesis to oogenesis in C. elegans hermaphrodites
32. More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line
33. Gain-of-function mutations of fern-3, a sex-determination gene in Caenorhabditis elegans
34. Activity of the sex-determining gene tra-2 is modulated to allow spermatogenesis in the C. elegans hermaphrodite
35. Analysis of the role of tra-1 in germline sex determination in the nematode Caenorhabditis elegans
36. TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans
37. A novel member of the tob family of proteins controls sexual fate in Caenorhabditis elegans germ cells
38. Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans
39. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans
40. A genetic pathway for regulation of tra-2 translation
41. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorabditis elegans, affect a conserved domain also found in Src-associated protein Sam68
42. STAR, a gene family involved in signal transduction and activation of RNA
43. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans
44. Analysis of the multiple roles of gld-1 in C. elegans germline development: Interactions with the sex determination cascade and the glp-1 signaling pathway
45. FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline
46. A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans
47. Control of the sperm-oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-33′ untranslated region
48. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line
49. Binding of Pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
50. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans
51. Recruitment of Nanos to hunchback mRNA by Pumilio
52. nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans
53. CPEB proteins control two key steps in spermatogenesis in C. elegans
54. Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein
55. Repression by the 3′ UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans
56. The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family
57. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22
58. Translational control during early development
59. Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences
60. Interspecies comparison reveals evolution of control regions in the nematode sex-determining gene tra-2
61. Regulatory elements required for development of Caenorhabditis elegans hermaphrodites are conserved in the tra-2 homologue of C. remanei, a male/female sister species
62. More is not better: Brood size and population growth in a self-fertilizing nematode
63. Temperature-dependent sex determination: The interplay of steroid hormones and temperature
64. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
65. A global profile of germline gene expression in C. elegans
66. Molecular analysis of tra-2, a sex determining gene in C. elegans